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Usage of forsythiaside for preparing medicine treating senile dementia

A technology for forsythiaside and medicine, applied in the field of medicine, can solve the problems of nervous system diseases and the like that have not yet been seen with forsythiaside

Inactive Publication Date: 2010-06-23
INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, there has been no report on the use of forsythiaside for the treatment of neurological diseases, especially the treatment of senile dementia.

Method used

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  • Usage of forsythiaside for preparing medicine treating senile dementia
  • Usage of forsythiaside for preparing medicine treating senile dementia
  • Usage of forsythiaside for preparing medicine treating senile dementia

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0021] Experimental example 1: Study on the neuroprotective effect of forsythiaside against PC12 cell injury model

[0022] 1. Materials

[0023] 1.1 Drugs

[0024] Forsythiaside was prepared by the Chemistry Department of the Institute of Medicinal Plants, Chinese Academy of Medical Sciences.

[0025] 1.2 cells

[0026] PC12 cells were provided by the Cell Center, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences.

[0027] 1.3 Main reagents and instruments

[0028] DMEM medium was purchased from GIBCO Company, fetal bovine serum (FBS) was Sijiqing premium product, horse serum (HS) was product of Hyclone Company, thiazolyl blue (MTT) was purchased from Amresco Company. L-glutamic acid and β-amyloid are products of Sigma.

[0029] Disposable cell culture materials were purchased from Costar Company, Molecular Device Company SpectraMax190 type enzyme-linked immunosorbent detection instrument.

[0030] 2. Method

[0031] 2.1 MTT colorimetric method t...

experiment example 2

[0061] Experimental Example 2: Behavioral Study on Anti-senile Dementia Effect of Forsythiaside

[0062] 1. Materials

[0063] 1.1 Animals

[0064] Kunming mice, 10 months old, female, weighing 35-40g, BALB / C mice, 12 months old, female, weighing 28-32g, all provided by the Animal Center of the Chinese Academy of Medical Sciences, certificate number: SCXK (Beijing) 2004-0001. Placed in an SPF environment and raised. During the experiment, the animals had free access to food and water.

[0065] 1.2 Reagents

[0066] Forsythiaside is prepared by the chemical laboratory of the Institute of Medicinal Plants, Chinese Academy of Medical Sciences, with a purity of more than 95%; Scopolamine (scopolaminium bromide), produced by Merck, batch No. K26208347 912; Aricept (donepezil hydrochloride), manufactured by PFIZER PGM Company, Batch No. 6109803.

[0067] 1.3 Instruments

[0068] The mouse jumping platform tester and the mouse water maze tester are jointly developed by the Ins...

experiment example 3

[0102] Experimental Example 3: Study on the Mechanism of Forsythiaside in Anti-senile Dementia

[0103] 1.1 Animals

[0104] BALB / C mice, 12 months old, female, weighing 28-32 g, were provided by the Animal Center of the Chinese Academy of Medical Sciences, certificate number: SCXK (Beijing) 2004-0001. Placed in an SPF environment and raised. During the experiment, the animals had free access to food and water.

[0105] 1.2 Reagents

[0106] Forsythiaside is prepared by the chemical laboratory of the Institute of Medicinal Plants, Chinese Academy of Medical Sciences, with a purity of more than 95%; Scopolamine (scopolaminium bromide), manufactured by Merck, batch No. K26208347 912; Aricept (donepezil hydrochloride), manufactured by PFIZER PGM Company, Batch No.6109803; Ibuprofen, manufactured by Shanghai Johnson Pharmaceutical Co., Ltd., batch No.071106279; Vitamin E, manufactured by Beijing Shuanghe Pharmaceutical Co., Ltd., batch No.080107.

[0107] The kits used for the...

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Abstract

The invention discloses the application of forsythiaside in preparing medicine promoting nerve cell proliferation and protecting nerve cells; the application of forsythiaside in preparing medicine improving passive avoidance response and impaired spatial learning and memory and enhancing learning and memory; the application of forsythiaside in preparing medicine increasing the total protein content in cerebral cortex tissue; the application of forsythiaside in preparing medicine reducing the activity of acetylcholin esterase in cerebral cortex and hippocampus brain tissue; the application of forsythiaside in preparing medicine improving the activity of superoxide dismutase in cerebral cortex and hippocampus brain tissue, and reducing the malonaldehyde content and the monoamine oxidase activity in cerebral cortex and hippocampus brain tissue; the application of forsythiaside in preparing medicine reducing the content of inflammatory factor TNF-alpha and IL-6 in the brain tissue of cerebral cortex; and the application of forsythiaside in preparing medicine treating mild cognitive impairment, especially senile dementia.

Description

Field of invention: [0001] The invention relates to the technical field of medicine, in particular to the application of forsythiaside in the preparation of medicaments for treating senile dementia. Background technique: [0002] Senile dementia is one of the most difficult problems faced by human beings after entering the aging society, among which senile dementia (Alzheimer's disease, AD) and vascular dementia (VaD) are the most common, and senile dementia accounts for about 63%, followed by Is vascular dementia, accounting for about 27%. Senile dementia, also known as Alzheimer's disease (AD), is a degenerative disease of the central nervous system. The pathological manifestations of patients are brain atrophy, and the neurons and synapses in the central nervous region are significantly reduced or disappeared, accompanied by characteristic pathological changes such as a large number of neurofibrillary tangles (NFT) and senile plaques (SP). The pathogenic process of seni...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7028A61P25/28
Inventor 王忆杭潘瑞乐刘新民肖培根王立为赵晓宏斯建勇常琪
Owner INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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