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Preparation method, preparation and application of tricin

A technology for wheat flavin and medicine, applied in the field of preparation of wheat flavin, can solve the problems of uncontrollable quality, rough separation and purification process, etc., and achieve the effect of simple and easy process and high extraction rate

Inactive Publication Date: 2010-06-16
林新华 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] At present, there are no literature and patent reports on the anti-tumor activity of wheat xanthin in China, and there are disadvantages such as rough separation and purification process and uncontrollable quality.
And, also do not see on the market about the appearance of the medicine of wheat glutanin or pharmaceutical composition

Method used

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  • Preparation method, preparation and application of tricin

Examples

Experimental program
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Effect test

Embodiment 1

[0018] The preparation of embodiment one plant source wheat xanthin

[0019] The preparation method of plant source wheat xanthin of the present invention comprises the following steps: (1) extracting: after the botanical medicinal material that dries naturally is pulverized, after soaking with 8 times the amount of 70% ethanol, reflux extracts 3 times, filters, reduces The solvent is recovered by distillation under pressure to obtain the total extract; (2) separation and purification: the total extract is subjected to 100-200 mesh silica gel column chromatography, eluted with petroleum ether: ethyl acetate (1:1-1:10), and combined With the same components, the crude component of wheat xanthin was obtained. Multi-step recrystallization, and freeze-drying to obtain the fine wheat glutanthin. The purity of wheat xanthin was determined to be 98.3%.

Embodiment 2

[0020] The preparation of embodiment two plant source wheat xanthin

[0021] The preparation method of botanical wheat xanthin of the present invention comprises the following steps: (1) extracting: after the plant medicinal material that dries naturally is pulverized, after soaking with 10 times of 70% ethanol, Soxhlet extracts 3 times, filters, The solvent was recovered by distillation under reduced pressure to obtain the total extract; (2) separation and purification: the total extract was subjected to polyamide column chromatography, eluted with petroleum ether: ethyl acetate (1:1~1:10), and the same groups were combined points to obtain the crude component of wheat flavin. Multi-step recrystallization, and freeze-drying to obtain the fine wheat glutanthin. The purity of wheat xanthin was determined to be 98.5%.

Embodiment 3

[0022] The preparation of embodiment three plant sources wheat xanthin

[0023] The preparation method of plant source wheat xanthin of the present invention comprises the following steps: (1) extracting: after the plant medicinal material that dries naturally is pulverized, after soaking with 15 times of 70% ethanol, ultrasonically extracts 2 times, filters, reduces (2) Separation and purification: the total extract is subjected to macroporous resin column chromatography, eluted with petroleum ether: ethyl acetate (1: 1 ~ 1: 10), and the same groups are combined points to obtain the crude component of wheat flavin. Multi-step recrystallization, and freeze-drying to obtain the fine wheat glutanthin. The purity of wheat xanthin was determined to be 98.0%.

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Abstract

The invention relates to a preparation method, preparation and application of botanical tricin. The preparation method of the tricin comprises the following steps of: performing ultrasonic extraction on plant materials by aqueous or non-aqueous organic reagents used as solvents; filtering extract, performing reduced pressure distillation and recycling solvents to obtain total extract; performing chromatographic separation; combining identical components; and performing purification treatment to obtain fine tricin. The obtained tricin has high purity, and the content of the tricin can reach above 98 percent. The method has the advantages of simplicity, feasibility, short extraction time, low cost, high yield and low energy consumption and is suitable for industrial production. The obtained tricin can be prepared into various preparation formulations by a pharmaceutical method. Screening experiments of antitumor bio-activities prove that the tricin has significant curative effect on resisting tumors and can be applied to the preparation of antitumor medicaments or medicament compounds.

Description

technical field [0001] The invention relates to a preparation method, preparation and application of wheat xanthin. Background technique [0002] Tumor is one of the largest intractable diseases in the world today, and the death toll is still on the rise. It is surpassing cardiovascular disease and becoming the number one cause of population death. At present, most of the anti-tumor drugs used clinically are not highly selective for tumor cell inhibition and have high toxicity. Therefore, the research and development of highly efficient, low toxicity, and novel antitumor drugs is still a difficult task and a global scientific research topic. Studies in recent years have shown that traditional Chinese medicine plays an important role in the prevention and rehabilitation of tumors. And flavonoids are one of the main active ingredients in natural medicinal plants, which have broad-spectrum physiological activities such as regulating blood lipids, scavenging free radicals, ant...

Claims

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Application Information

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IPC IPC(8): C07D311/30C07D311/40A61K31/352A61P35/00
Inventor 林新华姚宏陈艳李少光李光文罗红斌
Owner 林新华
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