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Huperzine A oral formulation and a preparation method thereof

A technology for huperzine A and oral preparations, applied in the field of oral preparations of huperzine A and its preparation, can solve problems such as poor patient compliance, senile memory loss, etc., achieve fast absorption, high bioavailability, and improve patient The effect of compliance

Inactive Publication Date: 2010-06-16
武汉朗欧科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] 3. Senile memory loss
Since this product is mostly used for patients with senile dementia and mental disorders, the existing oral dosage forms have poor patient compliance during use. Huperzine A Dispersible Tablets can better improve drug compliance, and there is no such drug available in the market at present. Report on Huperzine A Dispersible Tablets

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A kind of huperzine A oral preparation of the present invention, prepares 1000 huperzine A dispersible tablets (specification: each contains huperzine A 0.05mg), uses following composition:

[0033] Material name Feed amount

[0034] Huperzine A 0.05g

[0035] Microcrystalline Cellulose 59.5g

[0036] 26g pregelatinized starch

[0037] Sodium carboxymethyl starch 10g

[0038] Micronized silica gel 3g

[0039] Magnesium Stearate 1g

[0040] Povidone K30 0.45g

[0041] Makes 1000 pieces

[0042] Process steps: crush the raw and auxiliary materials through an 80-mesh sieve, weigh 0.05 g of huperzine A, 59.5 g of microcrystalline cellulose, 26 g of pregelatinized starch, and 10 g of sodium carboxymethyl cellulose according to the prescription amount, mix thoroughly, and add polymerization Vitone K30 0.45g soft material made from aqueous solution, dried at 70°C for 3 hours, granulated, added with 3g of micropowdered silica gel and 1g of magnesium stearate, mixed evenl...

Embodiment 2

[0044] A kind of huperzine A oral preparation of the present invention, prepares 1000 huperzine A dispersible tablets (specification: each contains huperzine A 0.08mg), uses following composition:

[0045] Material name Feed amount

[0046] Huperzine A 0.08g

[0047] Microcrystalline Cellulose 85.5g

[0048] Low-substituted hydroxypropyl cellulose 10g

[0049] Micronized silica gel 3g

[0050] Magnesium Stearate 1g

[0051] Starch slurry 0.42g

[0052] Makes 1000 pieces

[0053] Process steps: crush the raw and auxiliary materials through an 80-mesh sieve, weigh 0.08 g of huperzine A, 85.5 g of microcrystalline cellulose, and 10 g of low-substituted hydroxypropyl cellulose according to the prescription amount, mix thoroughly, and add 0.42 g of starch slurry prepared by starch Make soft material, dry at 40°C for 6 hours, granulate, add micropowder silica gel 3g, magnesium stearate 1g, mix evenly, compress into tablets to obtain huperzine A dispersible tablets.

Embodiment 3

[0055] A kind of huperzine A oral preparation of the present invention, prepares 1000 huperzine A dispersible tablets (specification: each contains huperzine A 0.1mg), uses following composition:

[0056] Material name Feed amount

[0057] Huperzine A 0.1g

[0058] Microcrystalline Cellulose 75g

[0059] 15g pregelatinized starch

[0060] Hydroxyethylcellulose 4g

[0061] Talc powder 1g

[0062]Calcium Stearate 3g

[0063] Hypromellose 2g

[0064] Makes 1000 pieces

[0065] Process steps: crush the raw and auxiliary materials through an 80-mesh sieve, weigh 0.1g of huperzine A, 75g of microcrystalline cellulose, 15g of pregelatinized starch, and 4g of hydroxyethyl cellulose according to the prescription amount, mix well, add hypromellose Soft material made of ethanol solution prepared with 2g of cellulose, dried at 55°C for 5 hours, granulated, added with 1g of talcum powder and 3g of calcium stearate, mixed evenly, compressed into tablets to obtain huperzine A dispersi...

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PUM

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Abstract

The invention relates to a huperzine A oral formulation and a preparation method thereof. The formulation is prepared from huperzine A and officinal auxiliary materials, wherein the officinal auxiliary materials comprise water-insoluble excipient, disintegrant, adhesive and lubricant. The formulation is prepared from the following components by weight percentage: 0.005-1% of huperzine A, 0.1-99% of water-insoluble excipient, 0.1-10% of adhesive, 0.1-80% of disintegrant and 0.1-10% of lubricant. The invention improves the compliance of patients on the medicament and enhances the bioavailability of the medicament.

Description

technical field [0001] The invention relates to a dosage form of medicine, in particular to an oral preparation of huperzine A and a preparation method thereof. Background technique [0002] At present, about 400 million people in the world have entered the old age among the more than 5 billion people in the world. In the next 50 years, the number of the elderly will increase exponentially. Taking the United States as an example, by 2005, the elderly over 65 years old will account for 16% to 22% of the total population, that is to say, the number of people over 65 years old in the United States will increase from 1 / 9 in the past to 1 / 5. Of these people, about 12 percent have some form of learning and memory impairment, and there are about 5 million potential patients in the United States. In my country, 3.2% of the elderly over 60 years old suffer from this disease. As the world's population ages, the disease is one of the top three causes of disability in the elderly. Ho...

Claims

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Application Information

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IPC IPC(8): A61K31/4748A61K9/20A61K47/36A61K47/38A61P21/04A61P25/00A61P25/28
Inventor 胡明刚尹剑
Owner 武汉朗欧科技有限公司
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