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Combined medicament for supplementing zinc and calcium and preparation method thereof

A drug and uniform mixing technology, which is applied in the direction of drug combination, pharmaceutical formula, anhydride/acid/halide active ingredients, etc., can solve the problems that inorganic salts cannot be metabolized, are not suitable for long-term use, and cannot be absorbed by the body to achieve maintenance Blood acid-base balance, promoting physical growth and intellectual development, and promoting the body's metabolism

Active Publication Date: 2010-06-02
广西强寿药业集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are many kinds of drugs for supplementing zinc and calcium with different effects, including biologically active preparations and inorganic calcium-zinc salts. Use, even some inorganic salts cannot be metabolized in the body, stay in the body, and cause some diseases.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The main steps of the preparation method of the medicament formula for children of the present invention are:

[0035] (1) Press Zn 2+Weigh 10 g of solid zinc gluconate and 200,000 IU of solid vitamin D according to D3, 365 g of medicinal starch, 10 g of microcrystalline cellulose, and 10 g of micronized silica gel. First mix zinc gluconate and vitamin D to get No. 1 mixed powder, then mix medicinal starch and microcrystalline cellulose to get No. 2 mixed powder, then mix No. 1 and No. Micropowder silica gel is mixed evenly, and divided into 2000 capsules with enteric-coated capsules;

[0036] (2) Press Ca 2+ Count 200g and take the water-soluble calcium acetate that has been superfinely pulverized for subsequent use;

[0037] (3) 50 g of medicinal starch and 10 g of microcrystalline cellulose are mixed and set aside;

[0038] (4) Mix (2) and (3), add 20g of micro-powdered silica gel, mix well, and divide into 4000 capsules with halal capsules.

[0039] The two kin...

Embodiment 2

[0041] The main steps of the preparation method of the medicine formula for pregnant women of the present invention are:

[0042] (1) Press Zn 2+ Weigh 15g of solid zinc gluconate and 400,000IU of solid vitamin D according to D3, 330g of medicinal starch, 10g of microcrystalline cellulose, and 10g of micronized silica gel. First mix zinc gluconate and vitamin D evenly to get No. 1 mixed powder, then mix medicinal starch and microcrystalline fiber evenly to get No. 2 powder, then mix No. 10g is mixed evenly, and divided into 2000 capsules with enteric-coated capsules;

[0043] (2) Press Ca 2+ Total 300g takes by weighing the water-soluble calcium acetate of superfine pulverization for subsequent use;

[0044] (3) 55 g of medicinal starch and 15 g of microcrystalline cellulose are mixed and pulverized for subsequent use;

[0045] (4) Mix (2) and (3), add 20g of micro-powdered silica gel, mix well, and divide into 4000 capsules with halal capsules.

[0046] The two kinds of ...

Embodiment 3

[0048] The main steps of the preparation method of the pharmaceutical adult formula of the present invention are:

[0049] (1) Press Zn 2+ Weigh 10 g of solid zinc gluconate and 200,000 IU of solid vitamin D according to D3, 365 g of medicinal starch, 10 g of microcrystalline cellulose, and 10 g of micronized silica gel. First mix zinc gluconate and vitamin D to get No. 1 mixed powder, then mix medicinal starch and microcrystalline fiber to get No. 2 mixed powder, then mix No. 1 and No. Micropowder silica gel is mixed evenly, and divided into 2000 capsules with enteric-coated capsules;

[0050] (2) Press Ca 2+ Total 150g takes by weighing the water-soluble calcium acetate of superfine pulverization for subsequent use;

[0051] (3) 75g equivalent solid vitamin E based on 100% of vitamin E is added to β-cyclodextrin, the molar ratio of the two-phase formula is 1:1, the inclusion time is 25min, the solvent is 60% ethanol, and the inclusion complex is dried at low temperature f...

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Abstract

The invention relates to a combined medicament for supplementing zinc and calcium and a preparation method thereof. Medicament components are released at a fixed part. The preparation method comprises the following steps of: taking zinc gluconate and vitamin D, adding medicinal starch and microcrystalline cellulose and mixing, adding crushed superfine silica gel powder and evenly mixing and sub-packaging into enteric capsules; and mixing water-soluble calcium acetate, the medicinal starch and the microcrystalline cellulose, adding the crushed superfine silica gel powder and evenly mixing and sub-packaging into Muslim capsules. The medicament and the preparation method thereof ensure that the vitamin D cannot be damaged in an acid environment, avoid the direct stimulation of the zinc gluconate to the stomach and block off the direct contact of vitamin E and oxygen. After patients take two kinds of capsules, effective components of the vitamin E and the calcium acetate are rapidly disintegrated and absorbed in the stomach; the vitamin D and the zinc gluconate are disintegrated and absorbed in the intestine; and the invention has the characteristics of taking effect of medicament, high bioavailability, small side effect and the like, and is specially suitable for children, pregnant women, adults and old people for supplement and administration for a long term.

Description

Technical field: [0001] The invention relates to a medicine and a preparation method thereof, in particular to a combined zinc and calcium supplement medicine and a preparation method thereof. Background technique: [0002] At present, there are two problems in the calcium intake of Chinese nationals. First, on the whole, the national calcium intake is indeed low. The recommended daily calcium intake published by the Chinese Nutrition Society is 800 mg, and the recommended calcium intake for teenagers and pregnant women is 1200-1500 mg, but the current national daily calcium intake is about 400 mg. Second, the national calcium intake varies greatly from region to region, and not everyone is deficient in calcium. People in pastoral areas and people in areas with a high intake of soy products have sufficient calcium intake. Urban people who consume more eggs and milk and people who eat more fish along the coast also have sufficient calcium intake. The calcium intake of the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/575A61K31/191A61K31/19A61K9/48A61K31/355A61P3/02A61P3/14A61P3/12
Inventor 李浪辉
Owner 广西强寿药业集团有限公司
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