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Injectable composite material capable of promoting bone regeneration and repair and preparation method thereof

A composite material and bone regeneration technology, applied in the field of biomedical materials and regenerative medicine, can solve the problems of unsatisfactory osteoporotic fractures, difficult matching of degradation rate, poor biological activity, etc., to facilitate the transmission of nutrients and optimize biological Activity, promoting effect of cell proliferation

Inactive Publication Date: 2010-04-21
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the bioactivity of conventional materials for bone defect filling and repair is poor, and the materials constructed with dense micro-nano particles still have problems such as bone regeneration and material degradation rates that are difficult to match, and calcium phosphate self-curing materials are injected into fractures and cause thrombosis. Clinically, simple calcium phosphate ceramics, self-curing materials, and bioglass large particle filling materials cannot meet the requirements of osteoporotic fracture and defect repair.

Method used

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  • Injectable composite material capable of promoting bone regeneration and repair and preparation method thereof
  • Injectable composite material capable of promoting bone regeneration and repair and preparation method thereof
  • Injectable composite material capable of promoting bone regeneration and repair and preparation method thereof

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Effect test

Embodiment 1

[0050] 1) Will contain SiO 3 2- , PO 4 3- Na 2 SiO 3 And Na 3 PO 4 The molar ratio of the inorganic salt is 1:10 and added to the sodium polyaspartate aqueous solution to control the sodium phosphate concentration to 10%, maintain the mixed solution at 37°C, and adjust the pH of the solution with hydrochloric acid under continuous conditions 7.0, continuous stirring to form a uniform solution, and then the Ca 2+ , Sr 2+ , Zn 2+ And Mg 2+ Ionic Ca(CH 3 COO) 2 ·H 2 O, SrCl 2 , ZnCl 2 And MgCl 2 The solution is added dropwise to the sodium phosphate mixed solution, Ca 2+ , Sr 2+ , Zn 2+ And Mg 2+ Total moles and SiO 3 2- And PO 4 3- The ratio of the total number of moles is 8:6. After the addition is complete, maintain the temperature of the solution and continue stirring and aging for 10 minutes, then stop stirring and filter to precipitate the multi-element co-doped calcium phosphate microspheres, and use deionized water and anhydrous Washed with ethanol 3 times, then filtered and...

Embodiment 2

[0056] The preparation method is the same as in Example 1, the difference is: Step 1) will contain PO 4 3- Na 2 HPO 4 ·2H 2 The molar ratio of O inorganic salt is 1:10 and added to the sodium polyacrylate aqueous solution, the sodium phosphate concentration is controlled to 10%, the mixed solution is maintained at 60°C, and the pH of the solution is adjusted to 4.8 with hydrochloric acid under continuous conditions. Stir continuously to form a uniform solution, and then add Ca 2+ , Sr 2+ , Zn 2+ And Mg 2+ Ion of CaCl 2 , SrCl 2 , ZnCl 2 And MgCl 2 The solution is added dropwise to the sodium phosphate mixed solution, Ca 2+ , Sr 2+ , Zn 2+ And Mg 2+ Total moles and PO 4 3- The ratio of the mole number of phosphate is 8:6. After the addition, the temperature of the solution is maintained and the octacalcium phosphate microsphere particles are partially transformed, and the hydroxyapatite and octacalcium phosphate composite with a slower degradation rate are obtained by maintaining t...

Embodiment 3

[0059] The preparation method is the same as in Example 1, the difference is: Step 1) will contain PO 4 3- Na 3 PO 4 Add the sodium polyacrylate aqueous solution at a molar ratio of 1:10, control the sodium phosphate concentration to 10%, maintain the mixed solution at 40°C, and adjust the pH of the solution to 6.8 with hydrochloric acid under continuous conditions, and continue stirring to form Homogeneous solution, then add Ca 2+ , Zn 2+ And Mg 2+ Ion of CaCl 2 , Zn(NO3) 2 And MgCl 2 The solution is added dropwise to the sodium phosphate mixed solution, Ca 2+ , Zn 2+ And Mg 2+ Total moles and PO 4 3- The ratio of the number of moles is 8:6. After the addition, the temperature of the solution is maintained and the solution is continuously stirred and aged for 360 minutes. The octacalcium phosphate microsphere particles are transformed to obtain hydroxyapatite microspheres with a slower degradation rate. Wash with water and absolute ethanol three times in sequence, then filter an...

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Abstract

The invention discloses an injectable composite material capable of promoting bone regeneration and repair. The injectable composite material is prepared by mixing sodium alginate, chitosan, multiple trace element, calcium phosphate porous microsphere and bioactive glass nanometer granules, preparing the mixture by using deionized water and cell culture fluid, and compounding the prepared mixture. The injectable composite material comprises the following components in percentage by mass: 0.10 to 0.50 percent of sodium alginate, 0.01 to 0.20 percent of chitosan, 5 to 30 percent of multiple trace element codoped calcium phosphate porous microsphere, 0.05 to 0.50 percent of bioactive glass, 25 to 55 percent of cell culture fluid and 30 to 45 percent of deionized water. The preparation process is simple; the prepared injectable composite material has the characteristics of excellent injectability and quick degradation; and a hydrogel network can concentrate calcium, phosphorous ion and trace elements degraded and released by inorganic particles and can promote the migration, growth, multiplication and differentiation of bone cell, thereby having effects of quickly inducing bone regeneration and promoting bone repair on endosteal microdamage, fracture or bone defect.

Description

Technical field [0001] The invention relates to a hydrogel-bioactive inorganic particle injectable composite bone repair material, a preparation method and application, and belongs to the technical field of biomedical materials and regenerative medicine. Background technique [0002] With the increasingly severe population expansion and aging era, the treatment of bone damage caused by osteoporosis has become an important issue in various countries. The basic characteristics of osteoporosis are decreased bone density and significantly increased bone fragility, and the risk of intraosseous micro-injury, fractures, and large-scale bone defects in the spine, femur, and wrist is greatly increased. [0003] At present, there is no particularly effective treatment for osteoporosis at home and abroad, and the main focus is on prevention. For a long time, the treatment of osteoporotic fractures and bone defects is mainly based on metal or alloy material internal fixation and joint replace...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/56A61L27/52A61L27/58
Inventor 苟中入杨贤燕甘亦来
Owner ZHEJIANG UNIV
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