Mitiglinide calcium dispersible tablet and preparation method thereof

A technology of mitiglinide calcium and dispersible tablets, which is applied in the field of dispersible tablets, can solve problems such as weight gain and patient hunger, and achieve the effects of short duration of action, fast onset of action, and good hardness

Inactive Publication Date: 2010-04-21
江西中兴汉方药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, the better drug for treating diabetes is mitiglinide calcium, which has a novel mechanism of action and quick onset, while traditional oral diabetes drugs continue to stimulate insulin secretion, and the use of this drug often makes patients feel hungry, thus Causes patients to keep eating and gain weight

Method used

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  • Mitiglinide calcium dispersible tablet and preparation method thereof
  • Mitiglinide calcium dispersible tablet and preparation method thereof
  • Mitiglinide calcium dispersible tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] (1) 5 parts of mitaglinide calcium, 75 parts of starch, 15 parts of microcrystalline cellulose, 16 parts of dextrin, and 1.0 part of magnesium stearate (external) were pulverized through a 100-mesh sieve, and set aside;

[0018] (2) The mitiglinide calcium of the prescribed amount is fully mixed with microcrystalline cellulose and starch by an equivalent incremental method;

[0019] (3) Add the dextrin and magnesium stearate added in the prescription amount into the mixer together, and dry mix for 30 minutes;

[0020] (4) Add pure water to the mixed raw and auxiliary materials, mix to make a soft material, and granulate with a 30-mesh screen;

[0021] (5) Dry the granules in an electric oven at 45°C for 4.5 hours;

[0022] (6) Add the supplementary materials added to the prescription amount into the dry granules, granulate with a 30-mesh sieve, and mix evenly;

[0023] (7) Tablet packaging.

Embodiment 2

[0025] (1) 4 parts of mitaglinide calcium, 60 parts of starch, 12 parts of microcrystalline cellulose, 12.8 parts of dextrin, and 0.8 part of magnesium stearate (external) were pulverized through a 100-mesh sieve, and set aside;

[0026] (2) The mitiglinide calcium of the prescribed amount is fully mixed with microcrystalline cellulose and starch by an equivalent incremental method;

[0027] (3) Add the dextrin and magnesium stearate added in the prescription amount into the mixer together, and dry mix for 20 minutes;

[0028] (4) Add pure water to the mixed raw and auxiliary materials, mix to make a soft material, and granulate with a 30-mesh screen;

[0029] (5) Dry the particles in a 40°C electric oven for 4 hours;

[0030] (6) Add the supplementary materials added to the prescription amount into the dry granules, granulate with a 30-mesh sieve, and mix evenly;

[0031] (7) Tablet packaging.

Embodiment 3

[0033] (1) 6 parts of mitaglinide calcium, 90 parts of starch, 18 parts of microcrystalline cellulose, 19.2 parts of dextrin, and 1.2 parts of magnesium stearate (external) were pulverized through a 100-mesh sieve, and set aside;

[0034] (2) The mitiglinide calcium of the prescribed amount is fully mixed with microcrystalline cellulose and starch by an equivalent incremental method;

[0035] (3) Add the dextrin and magnesium stearate added in the prescription amount into the mixer together, and dry mix for 40 minutes;

[0036] (4) Add pure water to the mixed raw and auxiliary materials, mix to make a soft material, and granulate with a 30-mesh screen;

[0037] (5) Dry the particles in an electric oven at 50°C for 5 hours;

[0038] (6) Add the supplementary materials added to the prescription amount into the dry granules, granulate with a 30-mesh sieve, and mix evenly;

[0039] (7) Tablet packaging.

[0040] Prescription Basis

[0041] Based on the properties of mitiglinid...

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PUM

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Abstract

The invention relates to a mitiglinide calcium dispersible tablet which is characterized by comprising the following materials parting parts by weight: 4-6 parts of mitiglinide calcium, 60-90 parts of starch, 12-18 parts of microcrystalline cellulose, 12.8-19.2 parts of dextrin, 0.8-1.2 parts of magnesium stearate and the balance of pure water. The invention has the advantages of rapid effect of blood sugar, short duration, capability of tabletting, good hardness and better disintegration.

Description

technical field [0001] The invention relates to a dispersible tablet, in particular to a mitiglinide calcium dispersible tablet and a preparation method thereof. Background technique [0002] At present, the better drug for treating diabetes is mitiglinide calcium, which has a novel mechanism of action and quick onset, while traditional oral diabetes drugs continue to stimulate insulin secretion, and the use of this drug often makes patients feel hungry, thus Causes patients to continue eating and gain weight. Contents of the invention [0003] The object of the present invention is to provide a mitiglinide calcium dispersible tablet and a preparation method thereof. The mitiglinide calcium dispersible tablet is a postprandial hypoglycemic drug with quick onset and high safety. [0004] The present invention is achieved in that it is characterized in that it is made up of following raw materials in parts by weight: [0005] 4-6 parts of mitiglinide calcium, 60-90 parts o...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/4035A61K47/36A61P3/10
Inventor 李建平
Owner 江西中兴汉方药业有限公司
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