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Improved method for preparing artery embolic agent

An embolizing agent, arterial technology, applied in the field of improved arterial embolizing agent preparation, can solve the problems of complicated operation, uncontrollable quality, high price of microsphere embolic agent, etc., and achieve the effect of improving therapeutic function

Inactive Publication Date: 2010-01-06
THE SECOND AFFILIATED HOSPITAL ARMY MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] "The present invention aims at the problems of high price, cumbersome operation, single function and uncontrollable quality of microsphere embolic agents currently used clinically, and provides a preparation method of multifunctional microsphere embolic agents

Method used

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Examples

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Effect test

Embodiment 1

[0026] 1. Prepare 8ml of doxorubicin hydrochloride solution with a concentration of 5g / L, add dropwise to 16ml of refined iodized oil containing 15% volume ratio of surfactant span80, keep a constant temperature of 23°C, and stir at 5000 rpm 2 minutes, make emulsion;

[0027] 2. Add 50 mg of calcium carbonate micropowder with a particle size of 110 nm to 10 ml of sodium alginate solution with a concentration of 1.0 g / L, and stir for 3 minutes at 8°C and 300 rpm.

[0028] 3. Mix the solution prepared in step 2) with the solution prepared in step 1) at a volume ratio of 1:1.3 to obtain an emulsion, and mix it with liquid paraffin at a ratio of 1:1.9 to obtain a product.

[0029] 4. Wash with a solution containing 0.2% Tween80 and 0.5% calcium chloride and then wash with sterile water for injection to obtain a product.

Embodiment 2

[0031] Except that the conditions of the following corresponding steps are different from those of Examples, other conditions are all the same as those of Example 1.

[0032] 1. Perform the reaction at 25°C and stir at 5000 rpm for 2 minutes to prepare the solution;

[0033] 2. The average particle size of calcium carbonate is 110nm;

[0034] 3. The solution prepared in step 2) is mixed with the solution prepared in step 1) in a volume ratio of 1:1;

[0035] 4. After washing the microspheres obtained in step 4) for 6 times with 0.2% Tween-80 and 0.5% calcium chloride solution, wash with sterile water for injection.

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Abstract

The invention relates to an improved method for preparing an artery embolic agent, which comprises the following steps: mixing 8ml of a doxorubicin hydrochloride solution containing 15-20 percent (by volume) of Span-80 used as a surface active agent and having concentration of 5-10g / L with 16ml of iodized oil used as an oily contrast agent at 23-25 DEG C; adding calcium carbonate to 10ml of a sodium alginate solution with concentration of 1-2 percent expressed in percentage by weight so as to enable the calcium carbonate to have the concentration of 2-3 percent expressed in percentage by weight; mixing the solutions prepared in the two steps according a volume ratio of 1:1.3; and mixing an obtained solution with liquid paraffin according to a volume ratio of 1:1.9-1:5 to obtain a product. Shown by testing, compared with a contrast group, the embolic agent obviously slows down tumor growth, and the tissue of a visible tumor has liquefactive necrosis, thus the embolic agent can obviously prolong the life time of a liver cancer animal model.

Description

technical field [0001] The invention relates to a preparation method of an arterial embolism, in particular to an improved preparation method of an arterial embolism. Background technique [0002] According to the invention patent application with application number 200610047127.4, "at present, the means of treating tumors mainly include surgical treatment, radiation therapy and chemical drug therapy, among which chemical therapy is the most common and important method. In the process of chemical drug treatment of tumors, the ideal The treatment should be that the blood drug concentration remains relatively constant in the narrow range between the lowest therapeutic level and the poisoning level for a long time. Local interventional slow-release technology is used to ensure that the tumor site has a higher drug concentration and a longer maintenance time. Chemotherapy is a relatively new research direction. Due to the low systemic side effects of local administration, it ope...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K47/44A61K47/14A61K47/36A61K47/02A61K31/704A61K49/04A61P35/00A61L31/18A61L31/16
Inventor 卢来春张蓉卢华宋明宝赵艳艳邢茂胡小刚
Owner THE SECOND AFFILIATED HOSPITAL ARMY MEDICAL UNIV
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