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Method for preparing gold/silver nano particle with stable hydroxylated dendritic polymers

A technology of silver nanoparticles and dendrimer, applied in the field of preparation of gold/silver nanoparticles

Inactive Publication Date: 2009-12-23
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The simple and spontaneous synthesis of hydroxylated dendrimer-stabilized gold / silver nanoparticles has not been reported yet

Method used

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  • Method for preparing gold/silver nano particle with stable hydroxylated dendritic polymers
  • Method for preparing gold/silver nano particle with stable hydroxylated dendritic polymers
  • Method for preparing gold/silver nano particle with stable hydroxylated dendritic polymers

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] (1) Dissolve G4.NH with a dry weight of 2.1164g in 50mL of methanol 2 . Then, hexane oxide (2.42 g, hexane oxide / dendrimer amino terminal molar ratio=2.5:1) dissolved in 50 mL of methanol solution was added dropwise while stirring, and the mixture was reacted for 72 hours, and methanol was removed with a rotary evaporator. The resultant was diluted with 10 mL of methanol, and was subjected to methanol dialysis (MWCO=3500 dialysis membrane, 6 times 4 liters) for 3 days to remove by-products and excess reactants. The remaining solution was mixed with water and lyophilized to give 2.65 g of solid G4.NHexylOH (65.9%).

[0046] (2) At room temperature, the 4th generation dendrimer methanol solution (3mL, 0.35mM) and HAuCl 4 Methanol solutions (3 mL, 3.5 mM) were mixed and stirred vigorously for 24 hours. After 12 hours of reaction, the solution turned dark red, indicating the spontaneous formation of gold nanoparticles. The mixture was then dried with a small flow of nit...

Embodiment 2

[0048] (1) Dissolve G4.NH with a dry weight of 3.0004g in 50mL of methanol 2 . Then, glycidol (1.9 g, glycidol / dendrimer terminal amino molar ratio=2.1:1) dissolved in 50 mL of methanol solution was added dropwise while stirring, and the mixture was reacted for 24 hours, and methanol was removed with a rotary evaporator. The resultant was diluted with water, and after 3 days of water dialysis (MWCO=3500 dialysis membrane, 6 times 4 liters) to remove by-products and excess reactants. The remaining solution was mixed with water and lyophilized to give 3.92 g of solid G4.NGlyOH (92.2%).

[0049] (2) At room temperature, G4.NGlyOH methanol solution (3mL, 0.35mM) and HAuCl 4 Methanol solutions (3 mL, 3.5 mM) were mixed and stirred vigorously for 24 hours. After 12 hours of reaction, the solution turned dark red, indicating the spontaneous formation of gold nanoparticles. The mixture was then dried with a small flow of nitrogen stream, and the mixture was redissolved in water an...

Embodiment 3

[0051] (1) Dissolve G4.NH with a dry weight of 3.0004g in 50mL of methanol 2. Then, glycidol (1.9 g, glycidol / dendrimer terminal amino molar ratio=2.1:1) dissolved in 50 mL of methanol solution was added dropwise while stirring, and the mixture was reacted for 24 hours, and methanol was removed with a rotary evaporator. The resultant was diluted with water, and after 3 days of water dialysis (MWCO=3500 dialysis membrane, 6 times 4 liters) to remove by-products and excess reactants. The remaining solution was mixed with water and lyophilized to give 3.92 g of solid G4.NGlyOH (92.2%).

[0052] (2) At room temperature, G4.NGlyOH aqueous solution (3mL, 0.35mM) and HAuCl 4 Aqueous solutions (3 mL, 3.5 mM) were combined and stirred vigorously for 24 hours. After 12 hours of reaction, the solution turned dark red, indicating the spontaneous formation of gold nanoparticles. Then freeze-dried to obtain {(Au 0 ) 10 -G4.NGlyOH}.

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Abstract

The invention relates to a method for preparing a gold / silver nano particle with stable hydroxylated dendritic polymers, comprising the following steps: (1) using 50 ml of methyl alcohol to dissolve dendritic polymers, dropping epoxy reagent, diluting and dialyzing the solution, and mixing the left solution with water, freezing and drying; (2) dissolving the solid dried in the step (1) in methyl alcohol or water, and mixing HAuCl4 methanol solution or HAuCl4 water solution, and stirring the solution till the solution changes into deep red; or dissolving the solid dried in the step (1) in methyl alcohol or water, mixing AgNO3 dissolved in methyl alcohol / water mixed solution (v / v =1:1), and stirring till the solution changes into dark brown. The invention has the advantages of simple method, gentle reaction condition, easy operation and prospect of industrializing implementation.

Description

technical field [0001] The invention belongs to the field of preparation of gold / silver nanoparticles, in particular to a method for preparing gold / silver nanoparticles stabilized by hydroxylated dendrimers. Background technique [0002] The application of noble metal nanoparticles (NPs), such as gold (Au) and silver (Ag) nanoparticles in medicine, has attracted considerable scientific and technological attention due to their unique optical, electronic, and quantum size-related properties , especially in the fields of biosensing, disease diagnosis, photothermal therapy, and drug and gene delivery. Among the numerous examples of polymer-assisted synthesis of metallic gold / silver nanoparticles, nanoparticles synthesized with dendrimers as templates or stabilizers have attracted a great deal of attention. This is mainly due to the unique structure and properties of this novel, highly branched and monodisperse synthetic dendrimer. The customizable surface chemistry of dendrime...

Claims

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Application Information

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IPC IPC(8): B22F9/24
Inventor 史向阳沈明武
Owner DONGHUA UNIV
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