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Traditional Chinese medicine pro-liposome injection for treating liver cancer and preparation process thereof

A proliposome, a technology for the treatment of liver cancer, applied in liposome delivery, antineoplastic drugs, drug combination, etc., can solve the multidrug resistance of cancer cells and other problems, to cover the bad smell of drugs, not easy to leak, Ease of use for promotion

Inactive Publication Date: 2009-12-23
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

5-Fluorouracil and doxorubicin are commonly used chemotherapeutic drugs in the treatment of liver cancer, but these drugs have strong toxic side effects
However, in the research and development of anticancer drugs, the multidrug resistance of cancer cells is a key issue affecting the progress of tumor chemotherapy.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0008] specific implementation plan

[0009] 1. Proliposome formulation and its preparation process

[0010] [Prescription] 16-25 parts of pepper eye kernel oil, 4-6 parts of turmeric oil, 2-4 parts of phospholipids, 0.5-1 part of cholesterol, 0.1-0.5 parts of VE oil, 8-10 parts of sorbitol

[0011] [Preparation process] According to the prescription, take the mixture of paprika seed oil kernel oil and zedoary oil, lecithin, cholesterol, VE oil, and dissolve it in 5 times the amount of ether or chloroform-ether (1:1) to form a clear substance. lipid solution. Separately weigh sorbitol through a 100-mesh sieve, place it in an eggplant-shaped bottle to preheat for 30 minutes, then add the above-mentioned lipid-like solution in portions, and evaporate the dry solvent on a constant-temperature water bath under reduced pressure until there is no peculiar smell. The prepared product was dried overnight in a vacuum desiccator, passed through a 40-mesh sieve, divided into 1000 vials...

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Abstract

The invention provides a traditional Chinese medicine pro-liposome injection for treating liver cancer and a preparation process thereof, belonging to the technical field of traditional Chinese medicine preparation. A prescription of the injection comprises 16 to 25 portions of the bunge pricklyash seed olein and 4 to 6 portions of the zedoary turmeric oil by weight. The preparation method comprises the following steps: the bunge pricklyash seed olein medicine materials and the zedoary turmeric oil are prepared to a pro-liposome taking sorbitol as a carrier after being mixed according to a certain ratio and a pro-liposome method. The pro-liposome is shaken by adding water used for injection before being used, and a liposome suspension is formed by hydration to be fed through intravenus drip. A product is a novel pure Chinese drug compound preparation, strengthens the targeting of the drug, enhances the bioavailability, increases the stability of the drug, conceals unpleasant odors, is beneficial to preservation and transportation, has rich raw material sources, low cost and simple preparation technology, and is easy to expand production.

Description

Technical field [0001] The invention belongs to the field of traditional Chinese medicines and pharmaceutical preparations thereof, in particular to a new dosage form of a compound traditional Chinese medicine for treating liver cancer and a preparation process thereof. Background technique [0002] Liver cancer is a common clinical malignant tumor, the incidence rate ranks third among tumors, and the prognosis is poor. 5-fluorouracil and doxorubicin are commonly used chemotherapeutic drugs in the treatment of liver cancer, but these drugs have strong toxic and side effects. It is urgent to develop new anticancer drugs with high efficiency and low toxicity. However, in the research and development of anticancer drugs, the multidrug resistance of cancer cells is a key issue affecting the progress of tumor chemotherapy. Studies have confirmed that traditional Chinese medicine has a wide range of pharmacological effects and few side effects, and can be applied to reverse mult...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K9/127A61K47/28A61K47/24A61K47/10A61P1/16A61P35/00
Inventor 王捷频王四旺尚福军王剑波袁娟丽
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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