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Water soluble decoquinate and method for preparing same

A kind of decoquinate, the technology of decoquinate, applied in the field of water-soluble decoquinate and its preparation, can solve the problems of unfavorable absorption, low bioavailability, decoquinate is not easily soluble in water, etc., to achieve Increase solubility, improve drug dispersion, and improve the effect of clinical utilization value

Inactive Publication Date: 2009-12-02
河南亚卫动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to provide a kind of water-soluble decoquinate and preparation method thereof, to overcome the current problems that decoquinate is not easily soluble in water, unfavorable for absorption and low bioavailability

Method used

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  • Water soluble decoquinate and method for preparing same
  • Water soluble decoquinate and method for preparing same

Examples

Experimental program
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Effect test

Embodiment 1

[0022] Get 1 part of decoquinate, 5 parts of polyethylene glycol 2000, and 1 part of sodium lauryl sulfate. Heat and melt polyethylene glycol 2000, add decoquinate and sodium lauryl sulfate, stir to disperse evenly, and vacuum dry to obtain a water-soluble decoquinate solid dispersion.

[0023] The above parts are parts by weight.

Embodiment 2

[0025] Take 1 part of decoquinate, 10 parts of polyethylene glycol 4000, and 2 parts of polysorbate-80. Heat and melt polyethylene glycol 4000, add decoquinate and polysorbate-80, stir to disperse evenly, and vacuum dry to obtain water-soluble decoquinate solid dispersion.

[0026] The above parts are parts by weight.

Embodiment 3

[0028] Take 1 part of decoquinate, 8 parts of polyethylene glycol 6000, and 1 part of sodium dodecylsulfonate. Heat and melt polyethylene glycol 6000, add decoquinate and sodium dodecylsulfonate, stir to disperse evenly, and vacuum dry to obtain water-soluble decoquinate solid dispersion.

[0029] The above parts are parts by weight.

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Abstract

The invention belongs to the technical field of medicaments, and particularly relates to water soluble decoquinate and a method for preparing the same. The water soluble decoquinate comprises the following raw materials in percentage by weight: 6 to 20 percent of decoquinate, 60 to 89 percent of polymer carrier, and 5 to 20 percent of solubilizer. The method comprises the following steps: adding the decoquinate and the solubilizer to the fused polymer carrier for even mixing, or preparing the decoquinate, the solubilizer and the polymer carrier into corresponding organic solutions respectively, and evenly mixing the organic solutions; and drying the mixed solution to obtain the water soluble decoquinate. The method adopts the solid dispersion technology to prepare the decoquinate into the solid dispersion of the water soluble decoquinate, thereby improving the dissolution rate of the decoquinate, increasing the dissolubility of the decoquinate, improving the biological utilization rate of the decoquinate, facilitating the clinical application and adding the clinical application value of the decoquinate.

Description

(1) Technical field [0001] The invention belongs to the technical field of medicine, in particular to a water-soluble decoquinate and a preparation method thereof. (2) Background technology [0002] Coccidiosis is a parasitic disease that parasitizes livestock, poultry, reptiles, amphibians, fish and some insects. It is distributed globally and spreads quickly. It mainly causes low immunity of the host, slow growth or even death. The development of the industry has caused great harm. Among them, it is the most harmful to the poultry industry. For example, chicken coccidiosis mostly occurs in chickens less than 3 months old, and the incidence rate is as high as 50-70%, and the case fatality rate is 20%-30%. The annual economic loss to the poultry industry exceeds $3 billion. [0003] The current method of preventing and treating coccidiosis is mainly to use anticoccidial drugs, add anticoccidial drugs to the feed, and prevent and treat coccidiosis by mixing materials or dri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/47A61K47/34A61K47/32A61K47/20A61P33/00A61K47/10
Inventor 李明魁张遂平郭芳茹薛慧俊周永亮
Owner 河南亚卫动物药业有限公司
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