Method for preparing Chinese traditional medicinal compound salvia miltiorrhiza preparation for curing cardiovascular and cerebrovascular diseases

Abstract

The invention discloses a method for preparing Chinese traditional medicinal compound salvia miltiorrhiza preparation for curing cardiovascular and cerebrovascular diseases, comprising the following steps: choosing salvia miltiorrhiza crude medicaments; slicing or crashing the salvia miltiorrhiza crude medicaments into coarse particles; extracting with water for 2-4 times at 20-80 DEG C; adding 4-12 quantities of water respectively for extracting for 1-3 hours; choosing panax notoginseng crude medicaments; slicing or crashing the panax notoginseng crude medicaments into coarse particles; adding water for decoction and extraction for 2-4times; adding 4-12 quantities of water respectively for decoction and extraction for 1-3 hours; combining extract of salvia miltiorrhiza water and extract of panax notoginseng water; regulating pH to be 1-7; mixing uniformly, standing for 0.5-12 hours; filtering or centrifuging; attaching supernatant fluid through macroporous to a resin column; washing until the effluent liquid reduces sugar to be negative; abandoning the washing liquid; using 30-100% of ethanol for elution; collecting elution liquid; recycling ethanol from the elution liquid; concentrating and drying the ethanol to obtain the extract of salvia miltiorrhiza and panax notoginseng; adding borneol flakes and accessories for preparing tablets, capsules, soft capsules, oral solution, dripping pills, spraying agents or granules.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a preparation method of a traditional Chinese medicine compound salvia miltiorrhiza preparation for treating cardiovascular and cerebrovascular diseases. Background technique [0002] Cardiovascular and cerebrovascular diseases are the first disease that causes human death. With the improvement of social living standards and the aging of the population, the research on drugs for cardiovascular and cerebrovascular diseases has become a hot spot in drug development. Coronary atherosclerotic heart disease, referred to as coronary heart disease, is caused by the deposition of some blood lipids such as cholesterol and triglycerides that cannot penetrate into the arterial wall to form "atheromatous plaque" on the intima of the artery. It makes the originally elastic arteries harden, and as the range of atherosclerotic plaques on the arterial intima increases, the b...

AI Technical Summary

Problems solved by technology

For example, according to "Chinese Pharmacopoeia" in 2005, a compound Danshen tablet needs to be extracted three times, add ethanol to reflux for 1.5 hours for the first time, filter, recover ethanol from the filtrate and concentrate it to an appropriate amount, and set aside; hour, the extract was filtered, the filtrate recovered ethanol and concentrated to an appropriate amount, and set aside; the dregs were decocted with water for 2 hours, the decoction was filtered, and the filtrate was concentrated to an appropriate amount. Salvianolic acid B is seriously lost due to prolonged heating; in the invention patent (Patent No. ZL 02157377.8) "a compound salvia miltiorrhiza preparation for treating cardiovascular and cerebrovascular diseases and its preparation method", the temperature of salvia miltiorrhiza was not controlled when the water was extracted, so that a large amount of salvia miltiorrhiza Destruction of Phenolic Acid B into Danshensu and Protocatechualdehyde with Low Activity under High Temperature

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