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Effective components of peony leaves as well as preparation method and application thereof

An effective component, peony leaf technology, applied in the field of research and development of new traditional Chinese medicines, can solve the problem of less peony leaves, etc., and achieve the effect of low cost and simple preparation process

Active Publication Date: 2009-11-11
北大世佳科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are few research reports on peony leaves

Method used

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  • Effective components of peony leaves as well as preparation method and application thereof
  • Effective components of peony leaves as well as preparation method and application thereof
  • Effective components of peony leaves as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1: the preparation method of effective component of peony leaf

[0035]Put 1kg of pulverized peony leaves into a reflux extraction tank, extract with water reflux, and extract three times each time for 3 hours, combine the extracts, directly adsorb on NKA-II resin, and elute with a continuous gradient of 0-50% ethanol. Conventional thin-layer chromatography followed and detected gallic acid and ethyl gallate in the eluate. First use 0-5% ethanol to elute and remove impurities, collect the latter 10-50% ethanol eluate, concentrate, heat and reflux with 60% ethanol for 3 hours, and obtain 15 g of effective components of peony leaves, wherein the content of gallic acid is 51.6%. The content of ethyl gallate is 20.9%.

[0036] Get the effective components of the above-mentioned peony leaves, and measure its monomer content with high-performance liquid chromatography, wherein the chromatographic conditions are:

[0037] High performance liquid chromatography: JA...

Embodiment 2

[0040] Embodiment 2: the preparation method of effective component of peony leaf

[0041] 1kg crushed peony leaf medicinal material, soaked in 95% ethanol for 2h, put into the percolation barrel, percolated with 95% ethanol, collected 30L percolated liquid, dissolved in water after concentration, directly adsorbed on DA201 macroporous resin, removed with water Miscellaneous, desorbed with 20% ethanol, collected the desorbed solution, concentrated, dried in vacuum, decocted in 50% ethanol for 1 hour, and obtained 20 g of active components of peony leaves, the content of gallic acid could reach 41.5%, and the content of ethyl gallate could reach 28.9%.

Embodiment 3

[0042] Embodiment 3: the preparation method of effective component of peony leaf

[0043] 1kg crushed peony leaves, soaked in 55% ethanol for 24 hours, collected 30L of soaking solution, concentrated and dissolved in 5% ethanol, directly adsorbed on S-8 macroporous resin, 5% ethanol to remove impurities, 25% ethanol to remove impurities, collected and desorbed liquid, concentrated, vacuum-dried, and decocted in 40% ethanol for 1 hour to obtain 18 g of effective components of peony leaves, the content of gallic acid can reach 49.6%, and the content of ethyl gallate can reach 25.3%.

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Abstract

The invention relates to effective components of peony leaves, which are separated and obtained from the peony leaves and mainly comprise gallic acid and progallin A, wherein the content of the gallic acid is 35-70 percent, and the content of the progallin A is 15-30 percent. The invention also provides a preparation method of the effective components of the peony leaves by adopting macroporous resin purification and provides a medicine preparation of the effective components. The animal experiment result shows that the effective components can effectively prevent and treat cardiovascular and cerebrovascular diseases and especially have the functions of preventing and treating the coronary heart disease and the cerebral ischemia disease.

Description

technical field [0001] The invention belongs to the field of research and development of new traditional Chinese medicines. The invention relates to an effective component isolated from peony leaves, and provides its preparation method, preparation and medical application. Background technique [0002] In recent years, with the aging of my country's population and the changes in people's work, life, diet structure and environment, the incidence of cardiovascular and cerebrovascular diseases such as coronary heart disease, angina pectoris, myocardial infarction, cerebral thrombosis, and sudden death has also increased year by year, and has become a major cause of human death today. One of the three diseases with the highest rate. Therefore, the development of therapeutic drugs with good curative effect and less toxic and side effects has a good market prospect, and has also become a research hotspot in the field of medicine. [0003] Cortex Moutan is the root bark of Paenoin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61K9/00A61P9/00A61P9/10A61K127/00
Inventor 周亚伟
Owner 北大世佳科技开发有限公司
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