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Method of extracting beta-sitosterol from n-pentanol solvent crystallization

A technology of n-pentanol and sitosterol, which is applied in the field of n-pentanol solvent crystallization to extract β-sitosterol, can solve the problems of many reaction steps, high equipment cost, and large environmental pollution, and achieve simple operation, easy recovery, and high yield high effect

Inactive Publication Date: 2009-09-30
SHANXI TIANWEI BIOLOGICAL PRODS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The above-mentioned method 1 has the disadvantages of many reaction steps, high cost, difficult operation, large environmental pollution and low solvent recovery rate in large-scale production.
The above method 2 has the advantages of simple operation, short process, short solvent, easy recovery and low environmental pollution. However, due to the small difference in solubility between the components of phytosterols, the selection of suitable solvents and operating conditions is the bottleneck for effective separation.
Although the above-mentioned method 3 has high extraction purity, the equipment cost is too large, and it is difficult to realize large-scale production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] (1) Under the condition of a temperature of 70°C, heat dissolve the crude sterols with a mass content of 50% of the mixed phytosterols with alcohol of 7 times the mass of the crude sterols, and remove impurities from the solution after the heat dissolution through microporous filtration, and filter the The final filtrate is poured into the cold analysis kettle, and after being cooled to 10° C., the filter cake is obtained by filtering with a plate and frame filter press, and the volume concentration of the alcohol is 95%;

[0022] (2) press filter cake: the mass ratio of alcohol=3: 1 puts the filter cake in the step (1) and alcohol into reaction kettle, after fully stirring, filter with plate and frame filter press again, the mixing in the gained filter cake after filtering The mass content of phytosterol reaches more than 90%, and the volume concentration of the alcohol is 95%;

[0023] (3) by n-amyl alcohol: the mass ratio of filter cake=4.2: 1, filter cake gained in ...

Embodiment 2

[0027] (1) Under the condition of a temperature of 70°C, use alcohol with 7 times the mass of crude sterols to thermally dissolve the crude sterols with a mass content of 55% of the mixed phytosterols, and remove impurities from the solution after thermal dissolution through microporous filtration, and filter The final filtrate is poured into the cold analysis kettle, and after being cooled to 10° C., the filter cake is obtained by filtering with a plate and frame filter press, and the volume concentration of the alcohol is 95%;

[0028] (2) press filter cake: the mass ratio of alcohol=3: 1 puts the filter cake in the step (1) and alcohol into reaction kettle, after fully stirring, filter with plate and frame filter press again, the mixing in the gained filter cake after filtering The mass content of phytosterol reaches more than 90%, and the volume concentration of the alcohol is 95%;

[0029] (3) by n-amyl alcohol: the mass ratio of filter cake=5: 1 adds filter cake and n-am...

Embodiment 3

[0033] (1) Under the condition of a temperature of 70°C, use alcohol with 7 times the mass of crude sterols to thermally dissolve the crude sterols with a mass content of 45% of the mixed phytosterols, and remove impurities from the solution after thermal dissolution through microporous filtration. The final filtrate is poured into the cold analysis kettle, and after being cooled to 10° C., the filter cake is obtained by filtering with a plate and frame filter press, and the volume concentration of the alcohol is 95%;

[0034] (2) press filter cake: the mass ratio of alcohol=3: 1 puts the filter cake in the step (1) and alcohol into reaction kettle, after fully stirring, filter with plate and frame filter press again, the mixing in the gained filter cake after filtering The mass content of phytosterol reaches more than 90%, and the volume concentration of the alcohol is 95%;

[0035] (3) by n-amyl alcohol: the mass ratio of filter cake=3: 1 adds filter cake and n-amyl alcohol ...

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Abstract

The invention discloses a method of extracting beta-sitosterol from n-pentanol solvent crystallization. Under certain temperature, alcohol of 95 percent with 7 times the amount of crude sterols is used to carry out thermal dissolution on the crude sterols; impurities are filtered through micropores; filter liquor is pumped into a cold separation reactor be filtered after being cooled to 10 DEG C; a filter cake and the alcohol are added into a reactor according to the mass ratio of 3 : 1, fully mixed and filtered; n-pentanol and the filter cake with the mass ratio of 3 to 5 : 1 are added into the reactor, temperature then rises to 40 DEGC plus / minus 2 DEG C, and the n-pentanol and the filter cake are fully mixed keeping the temperature unchanged; the steps are repeated to ensure that content of the beta-sitosterol in the filter cake achieves above 90 percent, and then the filter cake is dried in vacuum, crashed, sieved and packaged into a finished product. Compared with other solvent methods, the invention has high product yield and low cost. Solvent mixture is used in other solvent methods, while the invention uses single solvent n-pentanol having easy recovery and simple operation.

Description

technical field [0001] The invention relates to a method for extracting β-sitosterol, in particular to a method for extracting β-sitosterol by n-amyl alcohol solvent crystallization. Background technique [0002] β-sitosterol is a kind of phytosterol, which belongs to steroidal compounds, has strong anti-inflammatory and anti-inflammatory effects, and has antipyretic effect similar to acetylsalicylic acid (aspirin); long-term research experiments show that β-sitosterol -Sitosterol can inhibit colorectal cancer induced by chemical carcinogens; as we all know, phytosterols can effectively reduce serum cholesterol levels and play a role in the prevention and treatment of cardiovascular diseases such as hypertension and coronary heart disease. Recent studies have shown that β-sitosterol hinders cholesterol It shows quantity selectivity during absorption. When the cholesterol intake is less than 100mg, it hardly shows any hindering effect, but if it reaches 400-450mg, even if onl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J9/00
Inventor 吴振川刘俊杨春堂
Owner SHANXI TIANWEI BIOLOGICAL PRODS
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