Influenza-pandemic influenza bivalent combined vaccine and preparation method thereof
A combined vaccine and influenza vaccine technology, applied in the fields of influenza-pandemic influenza combined vaccine and its preparation, combined vaccine and its preparation, can solve problems such as no reports, reduce vaccine cost and market price, and reduce the number of vaccinations , significant economic benefits
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[0031] Its preparation process of oral influenza-pandemic influenza combined vaccine involved in the present invention is as follows:
[0032] (1) Preparation of influenza and avian influenza vaccine seed banks: Like other influenza vaccines of various dosage forms, a three-level seed bank of primary generation, main generation, and working generation should be established. The three-level seed bank must be verified: hemagglutination titer , virus titer, sterility test, mycoplasma, identification test, exogenous factors (poultry adenovirus, leukemia virus detection) and other items.
[0033] (2) Preparation of influenza and avian influenza virus liquid: working seeds are inoculated with chicken embryos, cultured, harvested virus liquid, clarified, filtered, purified and inactivated to make whole virus liquid, subject to verification: hemagglutination content, sterility Test, inactivation test, identification test and other items. After that, it is prepared according to the pr...
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