Preparation and use of Ziziphora general lavone

A technology of total flavonoids and Xintahua, which is applied in the field of preparation of extraction and separation of total flavonoids

Inactive Publication Date: 2009-08-26
XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the process of studying Xintahua, the present invention finds that Xintahua contains a large amount of flavonoids, but its extraction and preparation process has not yet been reported.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] a. Take 5 kg of Xintahua whole herb, grind it into 5 meshes, add 16 times of ethanol with 80% concentration, extract twice by conventional heating and reflux, each time for 1.5 hours, keep slightly boiling, combine the filtrates, concentrate and dry;

[0016] b. Disperse the extract in an aqueous solution to prepare an aqueous solution, then put the SA-3 macroporous resin column on the aqueous solution, wash it with water until it is colorless, then wash 6 column volumes with 50% ethanol solution, collect, concentrate, that is get total flavonoids.

[0017] The total flavonoids obtained by the method can be used as a medicine for treating hypertension, cardiovascular and cerebrovascular diseases and their complications, or as a raw material for preparing functional food and health products.

Embodiment 2

[0019] a. Take 5 kg of Xintahua whole herb, grind it into 5 meshes, add 10 times of methanol, extract by cold soaking for 3 times, each time for 2 hours, combine the filtrates, concentrate and dry;

[0020] b. Disperse the extract in an aqueous solution to prepare an aqueous solution, then put the FL-3 macroporous resin column on the aqueous solution, wash it with water until it is colorless, then wash it with 30% ethanol solution of 2 times the column volume, concentrate under reduced pressure, Vacuum drying to obtain total flavonoids.

[0021] The total flavonoids obtained by the method can be used as a medicine for treating hypertension, cardiovascular and cerebrovascular diseases and their complications, or as a raw material for preparing functional food and health products.

Embodiment 3

[0023] a. Take 5 kg of Xintahua whole herb, grind it into 5 meshes, add 15 times of water, use conventional microwave-assisted extraction twice, each time for 1 hour, combine the filtrates, and concentrate;

[0024] b. Disperse the extract in an aqueous solution to prepare an aqueous solution, then put the HP-20 macroporous resin column on the aqueous solution, wash it with water until it is colorless, then wash it with 80% ethanol solution of 6 times the column volume, concentrate under reduced pressure, Vacuum drying to obtain total flavonoids.

[0025] The total flavonoids obtained by the method can be used as a medicine for treating hypertension, cardiovascular and cerebrovascular diseases and their complications, or as a raw material for preparing functional food and health products.

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PUM

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Abstract

The invention relates to preparation and use of of Ziziphora general flavone. The preparation comprises extracting the Ziziphora in an organic solvent, mixing the extract, concentrating, dispersing the extract into water solution, performing macroporous resin column chromatography onto the water solution, washing by water untill colourless, washing in alcohol solution, collecting, concentrating and finally obtaining the general flavone. The material resources of the invention are rich, the extracting and concentrating process is simple, and it is easy to control the quality. The Ziziphora general flavone prepared by the invention can be used to prepare drugs for treating hypertension, cerebral-vascular disease, and complicating diseases thereof, or prepare raw materials of functional food and health products.

Description

technical field [0001] The invention relates to a preparation method for extracting and separating total flavonoids from xintahua. The total flavonoids obtained from xintahua are used in medicine and hygiene, food and chemical industry, etc. through the method. Background technique [0002] Xintahua is a commonly used medicinal material in Uyghur medicine. Its Latin name (Ziziphora bungeana Juz.) is taken orally by Uyghur people. It can relieve symptoms such as chest tightness and dizziness. System function and other diseases. Kyrgyzstan Academy of Medical Sciences made a preliminary study on the ingredients of xintahua and reported for the first time that it was used to treat cardiovascular diseases. The anti-lipid peroxidation effect of xintahua has a significant effect on the treatment of hypertension, cardiovascular and cerebrovascular and its complications. Studies have shown that the water extract of Xintahua has significant anti-acute myocardial ischemia and other e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A61P9/00A61P9/12A23L1/29A23L33/00
Inventor 阿吉艾克拜尔·艾萨史昊阿不都吾甫尔·热依木古丽
Owner XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
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