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Molecular engram microspheres preparation method using micro-fluidic reactor

A technology of molecularly imprinted microspheres and combinatorial synthesis, applied in the field of chemical engineering, can solve the problem of taking a lot of time

Inactive Publication Date: 2009-08-19
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

And in some tests, there are often many kinds of substances that need to be detected, and it is necessary to establish a molecularly imprinted library, such as the molecularly imprinted library for the detection of veterinary drug residues. It takes a lot of time to prepare these molecularly imprinted polymers.

Method used

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Examples

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Effect test

Embodiment 1

[0033] Screening of synthesis conditions of chloramphenicol molecularly imprinted microspheres.

[0034] in a set containing 4 In microfluidic reactors with microchannels, each group The type microchannel can synthesize microspheres under different conditions, and can obtain molecularly imprinted microspheres under four different conditions at the same time.

[0035]First prepare the dispersed phase solution, ultrasonically dissolve template molecule chloramphenicol in porogen or solvent chloroform, add functional monomer methacrylic acid or 4-vinylpyridine, crosslinking agent EDMA 60mmol, initiator azobisisobutyl Nitrile AIBN 0.24g, the solution was ultrasonically degassed for 5min, deoxygenated by nitrogen for 15min, and then the solution was moved into the syringe of the syringe pump (try to avoid air entering the syringe); to prepare a continuous phase solution, add the dispersant PVA to water, stir to dissolve , ultrasonic degassing for 5 minutes, nitrogen deoxygenati...

Embodiment 2

[0040] Screening of synthesis conditions of triazolone molecularly imprinted microspheres.

[0041] in a set containing 6 In microfluidic reactors with microchannels, each group The type microchannel can synthesize microspheres under different conditions, and can obtain molecularly imprinted microspheres under six different conditions at the same time.

[0042] First prepare the dispersed phase solution, ultrasonically dissolve the template molecule triazolone in porogen or solvent toluene, add functional monomer methacrylic acid or 4-vinylpyridine, crosslinking agent EDMA 60mmol, initiator azobisisobutyl Nitrile AIBN 0.20g, the solution was ultrasonically degassed for 6min, deoxygenated by nitrogen for 20min, and then the solution was moved into the syringe of the syringe pump (try to avoid air entering the syringe); to prepare a continuous phase solution, add the dispersant PVA to water, stir to dissolve , ultrasonic degassing for 5 minutes, nitrogen deoxygenation for 25...

Embodiment 3

[0047] Screening of synthesis conditions of oxytetracycline molecularly imprinted microspheres.

[0048] in a set containing 8 In microfluidic reactors with microchannels, each group The type microchannel can synthesize microspheres under different conditions, and can obtain 8 kinds of molecularly imprinted microspheres under different conditions at the same time.

[0049] First prepare the dispersed phase solution, ultrasonically dissolve template molecule oxytetracycline in porogen or solvent acetonitrile, add functional monomer methacrylic acid or 4-vinylpyridine, cross-linking agent EDMA 60mmol, initiator azodiiso Butyronitrile AIBN 0.20g, the solution was degassed by ultrasonic for 6min, deoxygenated by nitrogen for 20min, and then the solution was moved into the syringe of the syringe pump (try to avoid air entering the syringe); to prepare the continuous phase solution, add the surfactant Tween 80 Put it into liquid paraffin, stir to dissolve, ultrasonically degas f...

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Abstract

The invention relates to a method for combined synthesis of molecular engram microspheres through a micro-fluidic reactor, which is characterized in that a micro-fluidic reactor system comprises a fluid drive unit (an injection pump group), a liquid droplet or milk droplet forming unit and an ultraviolet illumination and polymerization unit, wherein the micro-fluidic reactor comprises n groups of '*'-shaped microchannels with the same structure, and can simultaneously prepare the molecular engram microspheres under n conditions or prepare the molecular engram microspheres of n template molecules; and dispersed phases and continuous phases are driven by injection pumps to enter respective microchannels and form milk droplets when encountering each other on crossings of the microchannels, and the prepared milk droplets arrive at the ultraviolet illumination unit for polymerization reaction.

Description

【Technical field】: [0001] The invention belongs to the technical field of chemical engineering, and relates to a method for synthesizing molecularly imprinted microspheres by using microfluidic reactors. 【Background technique】: [0002] Molecularly imprinted polymers (Molecularly Imprinted Polymers, usually abbreviated as MIPs) ). Due to the "lock-key" relationship between MIPs and target molecules, and the advantages of high selectivity and high strength (ie, heat resistance, organic solvent resistance, acid and alkali resistance), MIPs have been rapidly developed in recent years. Molecularly imprinted polymers have been widely used in drug analysis, veterinary drug residue detection, pesticide residue detection, antibody or receptor simulation, sensors and many other fields, and have shown good application prospects. [0003] Molecularly imprinted polymers reported in the early stage are usually blocky, have low resolution, and tend to cause chromatographic peak broadeni...

Claims

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Application Information

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IPC IPC(8): B01J19/00B01J13/02B01J20/30B01J20/285B01J20/28
Inventor 雷建都马光辉苏志国
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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