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Teniposide emulsion and preparation method thereof

A technology of niposide emulsion and teniposide, which is applied in the field of medicine, can solve the problems of patients with blood vessel blockage, instability, and large blood vessel irritation, and achieve the effects of reducing irritation and toxicity, stable properties, and convenient preparation

Inactive Publication Date: 2009-08-12
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Teniposide itself is almost insoluble in water. Internationally and domestically, it is prepared into teniposide injection. However, after taking the medicine, it is very irritating to the blood vessels of patients, and when it is diluted, it is often unstable and easily forms fine precipitates, causing the patient's local blood vessel blockage

Method used

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  • Teniposide emulsion and preparation method thereof
  • Teniposide emulsion and preparation method thereof
  • Teniposide emulsion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A method for preparing a teniposide emulsion, the composition of which is as follows:

[0025]

[0026] Include the following steps:

[0027] Mix the prescribed amount of Tween 80, Span 80, medicinal soybean oil, and purified water evenly to prepare a medicinal liquid for later use. Add teniposide powder to the medicinal liquid, disperse it through an ultrasonic emulsifier, filter and fill it, and extinguish it. Bacteria, serial number, and the product is obtained.

Embodiment 2

[0029] A method for preparing a teniposide emulsion, the composition of which is as follows:

[0030]

[0031] Include the following steps:

[0032] Dissolve the prescribed amount of teniposide in the mixed solution of lecithin, Span 20, and MCT to obtain an oil phase. At the same time, mix glycerin and purified water with magnetic stirring, add the oil phase to the water phase and disperse through a ultrasonic emulsifier. Filtration filling, sterilization, numbering, the product is obtained.

Embodiment 3

[0034] A method for preparing a teniposide emulsion, the composition of which is as follows:

[0035]

[0036] Include the following steps:

[0037] Dissolve the prescribed amount of teniposide in the purified water, lecithin, and oleic acid mixture solution, and stir for several minutes until each component dissolves to obtain an aqueous phase. At the same time, vitamin E is added to the medicinal soybean oil, heated and dissolved to obtain an oil phase. Add the oil phase to the water phase to disperse through an ultrasonic emulsifier, filter and fill, sterilize, and number to obtain the product.

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Abstract

The invention relates to the technical field of medicine and discloses a teniposide emulsion and a preparation method thereof. The formula of the teniposide emulsion comprises the following components by the preparation mass: 5% to 30% of oil phase, 0.001% to 1.0% of teniposide, 0.5% to 5% of surfactant and 64% to 94.499% of water phase. The teniposide emulsion can be prepared through the three methods as follows: adding teniposide powder to blank micro-emulsion and mixing to obtain the teniposide emulsion; or, adding teniposide to a water-soluble medium containing an emulsifying agent, mixing with the oil phase and stirring on a magnetic basis to obtain the teniposide emulsion; or, adding teniposide to the oil phase containing an emulsifying agent, then, mixing with the water phase and stirring on a magnetic basis to obtain the teniposide emulsion. The invention improves the stability, compliance and curative effect of teniposide, the insoluble drug, reduces the toxicity and vascular irritation thereof. The invention can be clinically prepared into injections, lyophilized powder and emulsions for oral administration.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a teniposide emulsion and a preparation method thereof, that is, the stability of teniposide is improved by preparing an oil-in-water emulsion. Background technique [0002] Teniposide (VM-26) is a semi-synthetic derivative of podophyllotoxin, which belongs to plant-derived antineoplastic drugs. It is a cycle-specific cytotoxic drug that inhibits DNA topoisomerase II, resulting in double-strand or single-strand damage, causing cell mitosis to stop in late S or early G2, thereby hindering tumor cell division and inhibiting tumor growth. Teniposide has a remarkable curative effect, and its biological activity is 5-10 times that of the same type of drug etoposide, and clinical data show that teniposide has few side effects, less toxicity, and has no effect on liver and kidney functions. Due to its extensive clinical antitumor activity, teniposide is now widely used in children with ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/7048A61K47/44A61K47/34A61P35/00A61K47/24A61K47/26
Inventor 韩静
Owner SHENYANG PHARMA UNIVERSITY
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