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Lactobacillus effervescent tablet and preparation method thereof

The technology of lactic acid bacteria and effervescent tablets is applied in the directions of pharmaceutical formulations, medical raw materials derived from bacteria, medical preparations containing active ingredients, etc. Achieve the effect of increasing the effective contact range and reducing the problem of antibiotic residues

Inactive Publication Date: 2009-08-05
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Endometritis is a common and frequently-occurring disease in dairy cow production. Once it occurs, dairy cows will have difficulty in mating or long-term infertility, resulting in low breeding efficiency and even early elimination
Clinically, antibiotic injection or infusion, traditional Chinese medicine therapy, combined Chinese and Western medicine therapy, hormone therapy, etc. are often used in clinical practice. Antibiotics are mainly used for treatment. Due to the problem of antibiotic residues and drug resistance and the application of antibiotics can cause bacterial flora imbalance, this disease Prolonged healing, the treatment effect is not satisfactory, causing huge economic losses to the dairy farming industry

Method used

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  • Lactobacillus effervescent tablet and preparation method thereof
  • Lactobacillus effervescent tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (1) After inoculating lactic acid bacteria into MRS medium and culturing at 37°C to induce the logarithmic phase of growth, centrifuge at 2000r / min for 10min, centrifuge out the bacterial cells, and make 3×10 9 cfu bacterial suspension, add (to the bacterial suspension) an equal amount of soluble starch, stir evenly, then freeze-dry or dry and pulverize at 45°C to 80 mesh fine powder;

[0033] (2) Take 100 g of lactic acid bacteria granules, 200 g of glucose, 210 g of citric acid, 240 g of sodium bicarbonate, 240 g of microcrystalline cellulose, an appropriate amount of starch, and 2 g of magnesium stearate.

[0034] (3) Weigh the prescribed amount of citric acid, microcrystalline cellulose, and 1 / 2 glucose, crush them through an 80-mesh sieve, mix them evenly, make acid granules with appropriate amount of water, and dry them at 45°C for later use; then weigh the prescribed amount of sodium bicarbonate , starch and 1 / 2 glucose were crushed through an 80-mesh sieve, mixe...

Embodiment 2

[0037] (1) After inoculating lactic acid bacteria into MRS medium and culturing at 37°C to induce the logarithmic phase of growth, centrifuge at 2000r / min for 10min, centrifuge out the bacterial cells, and make 3×10 9 cfu bacterial suspension, add (to the bacterial suspension) an equal amount of soluble starch, stir evenly, then freeze-dry or dry and pulverize at 45°C to 80 mesh fine powder;

[0038] (2) Take 150g of lactic acid bacteria granules, 150g of glucose, 150g of lactose, 150g of tartaric acid, 160g of sodium bicarbonate, 90g of microcrystalline cellulose, 60g of sodium lauryl sulfate, an appropriate amount of starch, and 2.5g of magnesium stearate.

[0039] (3) Weigh tartaric acid, microcrystalline cellulose, and glucose of the prescribed amount and crush them through an 80-mesh sieve. Sodium sulfate, starch and lactose were crushed through an 80-mesh sieve, mixed evenly, granulated with appropriate amount of water, and dried at 45°C for later use.

[0040] (4) Acid...

Embodiment 3

[0042] (1) After inoculating lactic acid bacteria into MRS medium and culturing at 37°C to induce the logarithmic phase of growth, centrifuge at 2000r / min for 10min, centrifuge out the bacterial cells, and make 3×10 9 cfu bacterial suspension, add (to the bacterial suspension) an equal amount of soluble starch, stir evenly, then freeze-dry or dry and pulverize at 45°C to 80 mesh fine powder;

[0043] (2) Take 10 g of lactic acid bacteria particles, 140 g of glucose, 140 g of lactose, 250 g of tartaric acid, 260 g of sodium bicarbonate, 150 g of microcrystalline cellulose, 50 g of sodium lauryl sulfate, and 2.0 g of talcum powder.

[0044] (3) Take tartaric acid, microcrystalline cellulose, and lactose of the prescribed amount, pulverize them through an 80-mesh sieve, mix them evenly, make acid granules with appropriate amount of water, and dry them at 45°C for later use; then weigh the prescribed amounts of sodium bicarbonate and dodecane Sodium bisulphate and glucose were cru...

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Abstract

The invention discloses a lactobacillus effervescent tablet, which is prepared from 1 to 15 portions of lactobacillus powder, 20 to 50 portions of auxiliary materials, 10 to 30 portions of acid sources, 11 to 30 portions of sodium bicarbonate, 2 to 35 portions of disintegrating agent and 0.2 to 2.5 portions of lubricant. The effervescent tablet transmits lactobacillus to various parts of the uterus after effervescence through an acid-base reaction, increases the effective contact range of the lactobacillus and the uterus, makes a larger area of the lactobacillus adsorbed and set by a mucous membrane of the uterus, avoids the use of ointment, a suppository and a liquid preparation, overcomes the defect that the medicine can be only sent to the bottom and the side wall of the uterus, and not only achieves the aims of treatment and prevention but also reduces in vivo antibiotic residue.

Description

technical field [0001] The invention belongs to the field of veterinary medicine and relates to a medicine for preventing and treating cow endometritis, in particular to a lactic acid bacteria effervescent tablet for preventing and treating cow endometritis and a preparation method thereof. Background technique [0002] Endometritis is a common and frequently-occurring disease in dairy cow production. Once it occurs, dairy cows will have difficulty in mating or long-term infertility, resulting in low breeding efficiency and even early elimination. Clinically, antibiotic injection or infusion, traditional Chinese medicine therapy, combined Chinese and Western medicine therapy, hormone therapy, etc. are often used in clinical practice. Antibiotics are mainly used for treatment. Due to the problem of antibiotic residues and drug resistance and the application of antibiotics can cause bacterial flora imbalance, this disease Prolonged healing, the treatment effect is not ideal, c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/74A61K9/46A61P15/00A61K35/744
Inventor 赵献军黄介鑫
Owner NORTHWEST A & F UNIV
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