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Medicament composition with stone-eliminating and expelling functions and preparation method thereof

A composition and drug technology, applied in the directions of drug combination, non-active ingredients medical preparations, medical preparations containing active ingredients, etc., can solve the problem of unsuitable diabetic patients to take, prone to caking during storage, and dosage of granules. Large and other problems, to achieve the effect of good appearance, convenient taking, and small dosage

Inactive Publication Date: 2010-10-20
SICHUAN XUHUA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation is a granule, and the dosage form is relatively backward. The dosage of the granule is large, and it needs to be taken with boiled water, and contains a large amount of sucrose, which is not suitable for diabetic patients, and the granule is easy to absorb moisture, and it is prone to agglomeration during storage.

Method used

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  • Medicament composition with stone-eliminating and expelling functions and preparation method thereof
  • Medicament composition with stone-eliminating and expelling functions and preparation method thereof
  • Medicament composition with stone-eliminating and expelling functions and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The preparation of embodiment 1 pharmaceutical composition tablet of the present invention

[0026] Raw materials of Chinese herbal medicine (unit: gram):

[0027] 375g of money grass, 375g of wangbuliuxing (stir-fried), 225g of coriander, 112.5g of corydalis (vinegar), 150g of gallinaceous gold (hot), 150g of salvia miltiorrhiza, 75g of woody fragrance, 187.5g of dianthus, 112.5g of achyranthes bidentata, seaweed Sands 150g.

[0028] medical supplements:

[0029] Starch 315g Magnesium Stearate 2.5g Sodium Carboxymethyl Starch 10g

[0030] The preparation method is as follows: among the above-mentioned 10 flavors of Chinese herbal medicines, take Haijinsha and Wangbuliuxing and put them into a cloth bag, add water to decoct with the other eight herbs such as Desmodium syringae for two times, the first time is 2.5 hours, and the second time is 1.5 hours. , combined decoction, filtered, concentrated under reduced pressure (75°C, -0.07Mpa) to an extract with a relative ...

Embodiment 2

[0031] The preparation of embodiment 2 pharmaceutical composition tablet of the present invention

[0032] Raw materials of Chinese herbal medicine:

[0033] Money Grass 16.7% Chao Wang Bu Liu Xing 16.7% Savings 10.0%

[0034] Vinegar Corydalis 5.0% Hot Chicken Neijin 6.7% Salvia 6.7%

[0035] Woody 3.3% Quma 8.4% Achyranthes 5.0%

[0036] Sea Sands 6.7%

[0037] medical supplements:

[0038] Starch 14.1% Magnesium Stearate 0.1% Sodium Carboxymethyl Starch 0.4%

[0039] The preparation method is as follows: among the above-mentioned 10 flavors of Chinese herbal medicines, take Haijinsha and Wangbuliuxing and put them into a cloth bag, add water to decoct with the other eight herbs such as Desmodium syringae for two times, the first time is 2.5 hours, and the second time is 1.5 hours. , combined decoction, filtered, concentrated under reduced pressure (75°C, -0.07Mpa) to an extract with a relative density of 1.25 (75°C); using starch as an auxiliary material, mixing, granu...

Embodiment 3

[0040] The preparation of embodiment 3 pharmaceutical composition tablet of the present invention

[0041] Raw materials of Chinese herbal medicine:

[0042] Money Grass 15.5% Chao Wang Bu Liu Xing 15.5% Savings 9.5%

[0043] Vinegar Corydalis 4.5% Hot Chicken Neijin 7.5% Salvia 7.5%

[0044] Woody 3.5% Quma 10% Achyranthes 4.5%

[0045] Sea Sands 7.5%

[0046] medical supplements:

[0047] Starch 14% Magnesium Stearate 0.15% Sodium Carboxymethyl Starch 0.35%

[0048] The preparation method is as follows: among the above-mentioned 10 flavors of Chinese herbal medicines, take Haijinsha and Wangbuliuxing and put them into a cloth bag, add water to decoct with the other eight herbs such as Desmodium syringae for two times, the first time is 2.5 hours, and the second time is 1.5 hours. , combined decoction, filtered, concentrated under reduced pressure (75°C, -0.07Mpa) to an extract with a relative density of 1.22 (78°C); using starch as an auxiliary material, mixing, granula...

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Abstract

The invention provides a medical composition with functions of dissolving and discharging stones, which is tablets prepared from Herba Lysimachiae, stir-fried cowherb seed, Common Knotgrass Herb, Corydalis tuber processed by vinegar, scalded Endothelium Corneum Gigeriae Galli, Salvia Miltrorrhiza, Radix Aucklandiae, fringed pink, Radix Cyathulae, Japanese Climbing Fern Spore, pharmaceutic adjuvants starch, magnesium stearate and sodium carboxymethyl starch which are taken as raw materials. A lubricant magnesium stearate is added by an equal quantity increasing method to improve particle fluidity and make particles pressed into the tablets; and a disintegrant sodium carboxymethyl starch is added by the equal quantity increasing method, so that the tablets can be disintegrated in 60 minutesto solve the difficult problem that the tables cannot be prepared and overcome the defect that the particles are easy to absorb damp. The preparation has the advantages of stability, safe administration, accurate dosage, controllable quality, reliable healing effect, high contents of effective ingredients, small administrative dosage, convenient administration, and is sugar-free to be suitable for more patients.

Description

technical field [0001] The invention relates to a pharmaceutical composition with fossil and calculus-dispelling functions; the invention also relates to a preparation method of the pharmaceutical composition, which belongs to the field of traditional Chinese medicine. Background technique [0002] Shenshitong Granule is a classic Chinese patent medicine. It is made into granules of ten kinds of Chinese herbal medicines, including money grass, stir-fried wang buliu xing, jellyfish, vinegar-made corydalis, hot chicken inner gold, salvia miltiorrhiza, woody incense, oatmeal, achyranthes bidentata, and sea jinsha. The Shenshitong granule has the functions of clearing away heat and promoting dampness, promoting blood circulation and relieving pain, removing fossils and removing stones, and is used for clinical treatment of diseases such as kidney stones, renal pelvis stones, ureteral stones and the like. However, the preparation is a granule, and the dosage form is relatively b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/53A61K47/36A61K36/36A61K36/66A61K36/285A61K36/704A61K35/37A61K36/11A61K36/21A61P13/04A61K9/20A61K35/57
Inventor 谢李李伟张文杰
Owner SICHUAN XUHUA PHARMA
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