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Extract of Pericarpium trichosanthis and Allium macrostemon, and preparation method thereof

A technology for the peel and extract of Trichosanthes quinquefolius, which is applied in the field of extracts and preparations of Trichosanthes wilted peel and Allium scallion, which can solve the problems of no clear quality control means, unfavorable long-term storage of aqueous solution, and the need for several grams or even dozens of grams. To achieve the effect of safety, no obvious side effects, good application prospects, and reduced dosage

Inactive Publication Date: 2009-06-24
江苏吴中苏药医药开发有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, Gualou Xiebai Decoction has not yet been developed as a drug, and it is used clinically as a decoction
There are many inconveniences in the use of traditional Chinese medicine: (1) Most traditional Chinese medicines are decocted in water, which requires special decoction tools. The operation is troublesome, the process is unstable, and the aqueous solution is not conducive to long-term storage. Seriously restrict the clinical use of
(2) Traditional Chinese medicines are taken in a large amount. After extraction by conventional water decoction, even if it is made into a preparation, several grams or even tens of grams are needed.
(3) Traditional Chinese medicine only identifies the authenticity of the source of the medicinal materials, but there is no clear control method for its quality, which makes it difficult to guarantee the quality of the medicinal materials and also affects the efficacy of the medicine

Method used

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  • Extract of Pericarpium trichosanthis and Allium macrostemon, and preparation method thereof
  • Extract of Pericarpium trichosanthis and Allium macrostemon, and preparation method thereof
  • Extract of Pericarpium trichosanthis and Allium macrostemon, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Preparation of Trichosanthes Bark and Scallion Extract

[0039] Mix Gualoupi and Allium scallions at a ratio of 1:1, put them in an extraction tank, add water to boil and extract three times. 2 hours, 2 hours for the second extraction, 2 hours for the third extraction, combined three extractions, filtered with a sieve, and the filtrate was concentrated in a vacuum distillation pot at 80°C under reduced pressure to an appropriate amount (concentrated to 2500ml of medicinal solution per kg of crude drug) ), add 90-95% ethanol while it is hot, stir while adding, until the alcohol content is 65% (according to the specific gravity of ethanol), let it stand for 36 hours, make it fully precipitate, filter the supernatant, precipitate and centrifuge , merge supernatant; Supernatant decompression reclaims ethanol, concentrates to 1ml recovery liquid and is equivalent to 1g crude drug, filters, and filtrate goes up 732 type cation exchange resin columns (resin) with the 1-2% flow...

Embodiment 2

[0044] Preparation of Trichosanthes Bark and Scallion Extract

[0045] Mix Trichosanthes bark and Allium scallions at a ratio of 1.5:1, put them in an extraction tank, add 20% ethanol to heat and reflux for extraction three times, and the volume of each solvent is 10 times, 8 times, and 8 times the mass of the medicinal materials respectively. Heat and extract for the first time for 3 hours, extract for the second time for 2 hours, extract for the third time for 2 hours, combine the three extracts, filter with a screen, and place the filtrate in a vacuum distillation pot to concentrate under reduced pressure to an appropriate amount (concentrated crude drug per kg) to 1500ml liquid medicine), add 90-95% ethanol while it is hot, stir while adding, add until the alcohol content is 75% (according to the specific gravity of ethanol), let it stand for 48 hours, make it fully precipitate, and filter the supernatant liquid, precipitate centrifugation, and combine the supernatant; the...

Embodiment 3

[0050] Mix the gua lou skin and scallion medicinal materials in a weight ratio of 2:1, put them in an extraction tank, add 45% ethanol and heat and reflux for extraction three times, the ion exchange resin extraction components and macroporous resin extraction components of gua lou skin and scallion The rest of the preparation method is the same as in Example 1. The ion-exchange resin extraction fraction and the macroporous resin extraction fraction of Trichosanthes barbatus and Allium scallops are taken according to the weight ratio of 50:50 to prepare the extracts of Trichosanthes barbas and Allium scallions.

[0051] The above-mentioned extract is dissolved in water according to a conventional process and filtered, and then an appropriate amount of refined honey is added to make an oral liquid.

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Abstract

The invention discloses a trichosanthes bark and allium macrostemon extract and a preparation method thereof. The composition is prepared by adopting the following steps: mixing trichosanthes bark with allium macrostemon in the weight proportion of 2:1 to 1:1; adding water or C1-3 ethanol with the concentration less than 50 percent for extraction; extracting an extracted solution by ion exchange resin and macroporous absorbent resin; extracting 50 to 90 weight portions of components from trichosanthes bark and the ion exchange resin of allium macrostemon; extracting 10 to 50 weight portions of components from the trichosanthes bark and macroporous resin of the allium macrostemon; mixing the two components; and obtaining the extract. The extract is applied to preparing medicines for treating diseases of cardiovascular system, and has determined curative efficacy; moreover, the extract reaches the goal of reducing dose without reducing medicine efficacy and has an extensive application prospect.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and specifically relates to an extract of melon wilt skin and allium scallion for treating diseases of the cardiovascular system and a preparation method thereof. Background technique [0002] Coronary heart disease belongs to the category of "chest obstruction" and "heart palpitation" in traditional Chinese medicine. The syndromes of traditional Chinese medicine are stagnation of qi and blood stasis, depression of chest yang, endogenous phlegm turbidity, and blockage of heart vessels to cause disease. "Gualou Xiebai (Baijiu) Decoction" is the first prescription of the Chest Obstruction, Heartache, and Shortness of Breath in "Synopsis of the Golden Chamber" by Zhang Zhongjing, a famous doctor in the Eastern Han Dynasty. Arthralgia, the clinical manifestations are chest and back pain, wheezing, coughing, shortness of breath, deep and stringy pulse and other symptoms, that is, t...

Claims

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Application Information

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IPC IPC(8): A61K36/8962A61P9/10
Inventor 顾维沈晓兰朱晶晶楼凤昌
Owner 江苏吴中苏药医药开发有限责任公司
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