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Gelatine enteric capsule shell material

A technology of enteric-coated capsules and shell materials, which is applied in the field of materials and can solve problems such as cumbersome processes, fires and explosions

Inactive Publication Date: 2009-06-24
吴国庆
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the production of gelatin enteric-coated hard and soft capsules is dipped twice, the process of producing gelatin enteric-coated hard and soft capsule shells is relatively cumbersome
In addition, enteric-coated materials also need to use a large amount of organic solvents, which are prone to fire and explosion incidents

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0064] The preparation method of the gelatin enteric-coated hard and soft capsule shells of the present invention can be carried out on existing equipment for preparing gelatin hard and soft capsule shells. Under the condition that no additional equipment is required, the desired gelatin enteric-coated hard and soft capsule shells can be produced by adjusting the drying temperature, humidity, film thickness, operating speed, mold size and other parameters according to the formula.

[0065] Advantages of the invention

[0066] Compared with the prior art, the main advantages of the present invention are:

[0067] (1) The present invention prepares gelatin enteric-coated hard capsules by one-time dipping and molding, which overcomes the preparation of gelatin enteric-coated hard capsules and soft capsules by dipping and molding twice.

[0068] (2) The present invention overcomes the need to use a large amount of organic solvents for the preparation of enteric-coated materials f...

Embodiment 1

[0080] Gelatin enteric hard capsule shell material 1

[0081] formula Dosage Highly acetylated gellan gum (acetylated

degree of 50%) 0.5 grams

gelatin 10gram Hypromellose Phthalate

Vitamins 12 grams

calcium chloride 0.4 grams ammonia 10ml (10 grams) Deionized water 67.1 grams

[0082] The preparation method is as follows: take highly acetylated gellan gum, hypromellose phthalate, ammonia water, and calcium chloride, pour them into deionized water, and heat to 100°C. Dissolve evenly, then lower the temperature to 80°C, add gelatin and stir evenly, after heat preservation and defoaming, dip the glue once to obtain a hard capsule shell, dry at 35°C, the water content of the capsule shell is 13%, and the prepared The gelatin enteric-coated hard capsule shell is smooth and elastic.

[0083] Measured according to the disintegration standard of enteric-coated hard capsules of Chinese Pharmacopoeia 2005 edition, the c...

Embodiment 2

[0085] Gelatin enteric hard capsule shell material 2

[0086] formula Dosage iota carrageenan 2.5 grams gelatin 10gram 1.2.4-Benzenetricarboxylic acid cellulose acetate 18.75 grams calcium chloride 1.25 grams Deionized water 61.25 grams Sodium carbonate 6.25 grams

[0087] The preparation method is as follows: take iota-type carrageenan, gelatin, calcium chloride, 1.2.4-benzenetricarboxylic acid cellulose acetate, and sodium carbonate, pour them into deionized water, and heat to 100°C. Dissolved evenly, after heat preservation and defoaming, the enteric-coated hard capsule shell was dipped in glue once, dried at 30°C, the water content of the capsule shell was 16%, and the obtained non-gelatin enteric-coated hard capsule shell was smooth and elastic.

[0088] Measured according to the disintegration standard of enteric-coated hard capsules of Chinese Pharmacopoeia 2005 edition, the capsule disintegration time is 35 minut...

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PUM

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Abstract

The invention provides a gelatin enteric-coated capsule shell material, which contains the following components by weight portion: (A) 10 to 25 weight portions of gelatin; (B) 10 to 30 weight portions of enteric coating material; (C) 13 to 30 weight portions of water; and (D) 0.01 to 20 weight portions of pH regulator, wherein the material basically does not contain an organic solvent. The invention provides the enteric-coated capsule shell material which has good performance, does not need the organic solvent, and is also suitable for producing on the prior hard and soft gelatin capsule production line.

Description

technical field [0001] The invention relates to the field of materials, in particular to the components and production method of gelatin enteric-coated capsule shells. Background technique [0002] At present, the film of enteric-coated hard and soft capsules (that is, the shell material of enteric-coated capsules) uses gelatin extracted from animal bones or skins such as cattle, sheep, and pigs as raw materials to make gastric-soluble hard and soft capsules. agent blank, and then use enteric-coated materials such as shellac, polyvinyl alcohol acetate phthalate, acrylic resins, cellulose derivatives (cellulose acetate phthalate, cellulose acetate 1.2.4-benzenetricarboxylate) , hydroxypropylmethylcellulose phthalate, 1.2.4-hydroxypropylmethylcellulose benzenetricarboxylate, cellulose acetate succinate and hydroxypropylmethylcellulose acetate succinate) and other organic solvents The glue solution is dipped in glue or spray-coated on the prepared stomach-soluble hard and soft...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/42A61K47/32A61K47/38
Inventor 吴国庆
Owner 吴国庆
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