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Mixed biology artificial liver vitro supporting device

A bioartificial and supporting device technology, applied in dialysis systems, etc., to achieve the effects of easy implementation, simple structure, and avoiding toxic effects

Inactive Publication Date: 2012-04-18
THE AFFILIATED DRUM TOWER HOSPITAL MEDICAL SCHOOL OF NANJING UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to overcome the defects of the above-mentioned non-bioartificial liver and bioartificial liver, and to design and develop a hybrid bioartificial liver support device in vitro

Method used

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  • Mixed biology artificial liver vitro supporting device
  • Mixed biology artificial liver vitro supporting device
  • Mixed biology artificial liver vitro supporting device

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Embodiment Construction

[0022] Summary of the invention of the present invention is as follows:

[0023] 1. Plasma replacement: plasma replacement components include input pump, heparin pump, plasma separator, plasma bag, waste plasma tank and blood pool, and the plasma replacement component is located before the plasma perfusion component. After the blood is separated from the plasma by the plasma separator, it is discarded directly, and the fresh plasma is replenished synchronously and at the same speed by the plasma bag. Part of the toxic substances are removed by plasma exchange.

[0024] 2. Plasma perfusion: The plasma perfusion part includes a hemoperfusion pump and a bilirubin adsorption column. The adsorption column is equipped with activated carbon. The plasma perfusion part is located after the plasma replacement part and before the bioartificial liver part. The plasma separated by the plasma separator is adsorbed by the activated carbon adsorption column to remove bilirubin and the like. ...

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Abstract

The invention relates to an in vitro supporting device for a mixed biological artificial liver temporarily replacing the liver function of human body. The structure of the in vitro supporting device for the mixed biological artificial liver is as follows: a bioreactor in an incubator is connected with a reactor circulating pump and a membrane lung which is connected with an exchange column; the exchange column is connected with the reactor circulating pump; a blood pump is connected with a blood inlet and a separation tube; a blood plasma infusion pump is connected with a tee joint and an active carbon absorption column; a biological artificial liver pump is connected with the active carbon adsorption column and the exchange column; a dialysis pump is connected with the exchange column and a dialysis tube; the separation tube is connected with a blood pool and the tee joint which is connected with a discarded blood plasma reservoir and the blood plasma infusion pump; the active carbonadsorption column is connected with the artificial liver pump; the dialysis pump is connected with the blood pool, a dialyzate bag and a waste fluid reservoir; and the blood pool is connected with a blood outlet. The in vitro supporting device for the mixed biological artificial liver solves the respective defects of a non-biological artificial liver and a biological artificial liver, organicallycombines the non-biological artificial live and the biological artificial liver to generate synergistic reaction, and achieves the aims of plasma exchange, plasma infusion, biological artificial liver dialysis and hemodialysis.

Description

technical field [0001] The invention relates to a medical device, in particular to a hybrid bioartificial liver extracorporeal support device temporarily replacing the liver function of a human body. Background technique [0002] The artificial liver device can provide short-term liver function support for patients. It is an effective adjuvant treatment for diseases such as liver failure and has a good application prospect. [0003] Before the present invention, artificial liver devices were mainly divided into two categories: non-biological artificial liver and biological artificial liver. [0004] The development of non-biological artificial liver is relatively mature at present, and the commonly used artificial liver devices include the following types: plasma exchange, plasma perfusion adsorption, hemodialysis and hemofiltration devices, etc. The plasma exchange device uses plasma separation technology to separate the cellular components and plasma components in the pat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M1/14
Inventor 丁义涛施晓雷褚薛慧顾劲扬
Owner THE AFFILIATED DRUM TOWER HOSPITAL MEDICAL SCHOOL OF NANJING UNIV
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