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Naphazoline hydrochloride, chlorphenamine maleate and vitamin B12 eye drops without bacteria inhibitor and preparation method thereof

A technology of naphthalene-vitamin eye drops and bacterial agent, applied in the field of naphthalene-vitamin eye drops and preparation thereof, can solve problems such as high risk, achieve the effects of saving cost and avoiding toxic and side effects

Inactive Publication Date: 2009-06-17
HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Especially for eye drops that need to be used frequently, the potential danger is greater

Method used

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  • Naphazoline hydrochloride, chlorphenamine maleate and vitamin B12 eye drops without bacteria inhibitor and preparation method thereof
  • Naphazoline hydrochloride, chlorphenamine maleate and vitamin B12 eye drops without bacteria inhibitor and preparation method thereof
  • Naphazoline hydrochloride, chlorphenamine maleate and vitamin B12 eye drops without bacteria inhibitor and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] prescription:

[0043]

[0044] Its preparation method:

[0045] a. Precisely weigh 0.02g naphazoline hydrochloride, 0.2g chlorpheniramine maleate, and 0.1g vitamin B 12 , 1.0g citric acid, 25.0g glycerol, dissolve in 200mL water for injection, adjust the pH to 4.5-6.0 with 10% sodium hydroxide solution, stir evenly, dilute the volume to 1000mL with water for injection to obtain the medicinal solution.

[0046] b. Filter the above-mentioned drug solution once with a 0.45μm microporous filter membrane, and filter it twice with a 0.22μm microporous membrane in a hundred-level environment.

[0047] c. After the drug solution is qualified, fill 0.4mL of the above drug solution into a 1mL single-dose packaging plastic container in a hundred-level environment, and seal it to obtain the finished product.

Embodiment 2

[0049] prescription:

[0050]

[0051]

[0052] Its preparation method:

[0053] a. Precisely weigh 0.02g naphazoline hydrochloride, 0.2g chlorpheniramine maleate, and 0.1g vitamin B 12, 1.0g citric acid, 30.6g glucose, 1.0g sodium hyaluronate, add 250mL water for injection to dissolve, adjust the pH to 4.5-6.0 with 10% sodium hydroxide solution, after stirring, dilute to 1000mL with water for injection, get the medicine liquid.

[0054] b. Filter the above-mentioned drug solution once through a 0.45μm microporous filter membrane, and then filter it through a 0.22μm microporous membrane twice in a hundred-level environment.

[0055] c. After the liquid medicine has passed the inspection, fill 0.8 mL of the above liquid medicine into a 1 mL single-dose packaging plastic container under a hundred-level environment, and seal the finished product.

Embodiment 3

[0057] prescription:

[0058]

[0059] Its preparation method:

[0060] a. Precisely weigh 0.02g naphazoline hydrochloride, 0.2g chlorpheniramine maleate, and 0.1g vitamin B 12 , 3.2g sodium dihydrogen phosphate, 5.6g disodium hydrogen phosphate, 12.0g glycerin, add 200mL water for injection to dissolve, stir well, dilute the volume to 1000mL with water for injection to obtain the medicinal solution.

[0061] b. Filter the above-mentioned drug solution once through a 0.45μm microporous filter membrane, and then filter it through a 0.22μm microporous membrane twice in a hundred-level environment.

[0062] c. After the liquid medicine has passed the inspection, fill 0.8 mL of the above liquid medicine into a 1 mL single-dose packaging plastic container under a hundred-level environment, and seal the finished product.

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Abstract

The present invention discloses a naphazoline hydrochloride, chlorphenamine maleate and vitamin B12 eye drops which do not contain bacteriostat and a preparing method thereof, wherein the naphazoline hydrochloride, chlorphenamine maleate and vitamin B12 eye drops comprise naphazoline hydrochloride, chlorphenamine maleate, vitamin B12, pH modifying agent, isoosmotic agent, stabilizing agent, thickening agent, etc. The preparing method adopts an aseptic manipulation filling technique. Furthermore the eye drops of the invention adopt a disposable single-dose independent packaging. The sterilized performance of product is guaranteed. The product is safer, more reliable, easier and more sanitary.

Description

Technical field [0001] The invention belongs to the field of pharmacy, and particularly relates to a naphthalene divinyl eye drops containing no bacteriostatic agent and a preparation method thereof. Background technique [0002] Eye drops are widely used in the treatment and prevention of various ophthalmological diseases. Naminwei eye drops occupies an important position in the fight against eye fatigue and dry eye disease. According to a survey conducted by Beijing Meilande Medical Information Consulting Co., Ltd. on household ophthalmic medications in 30 provincial capitals across the country from May to June 2004, Naminwei eye drops (also known as: Eye drops) occupies 14.8% of the total purchase amount. Among various anti-fatigue eye drops on the market, Naminwei eye drops rank first. With the rapid development of modern society, especially the widespread use of computers, the number of people suffering from eye fatigue and dry eye disease has gradually increased. People's d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/4164A61K31/4402A61K31/714A61P27/02
Inventor 姚军
Owner HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
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