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Surface hydrophilic modification of polystyrene material and product

A polystyrene and hydrophilic modification technology, which is applied in the direction of material separation, analysis materials, measuring devices, etc., can solve the problems of unsuitability and inability to effectively cover the hydrophobic surface of polystyrene, and achieve the improvement of hydrophilicity and non-specificity The effect of reducing the adsorption capacity

Active Publication Date: 2009-05-27
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This β-cyclodextrin copolymer is an oligomer, which cannot effectively cover the hydrophobic surface of polystyrene, and is not suitable as a separation matrix for biomacromolecules

Method used

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  • Surface hydrophilic modification of polystyrene material and product
  • Surface hydrophilic modification of polystyrene material and product
  • Surface hydrophilic modification of polystyrene material and product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] A Chloroacetylation of polystyrene

[0042] Add 0.8g of ordinary polystyrene plate, 20ml of dichloromethane, 1.2g of anhydrous aluminum trichloride to a 50ml flask, stir with a magnet, the solution turns yellow, then add 0.8ml of chloroacetyl chloride dropwise, and react in an oil bath at 30°C 5h. The reaction solution was suction-filtered in anhydrous state, the separated solid matter was quickly poured into glacial hydrochloric acid and stirred, filtered again and washed with deionized water until neutral, finally washed and filtered with absolute ethanol, and dried in a vacuum oven.

[0043] Chloroacetylated polystyrene after drying is measured chlorine content with sodium hydroxide melting method, and infrared spectrum (FTIR) analysis shows, sample compares in 1683cm before reaction. -1 A strong carbonyl stretching vibration absorption peak connected to the benzene ring appears at 645cm -1 A strong chlorine atom (-Cl) stretching vibration peak appears at the cente...

Embodiment 2

[0047] A Chloroacetylation of polystyrene

[0048] Add 0.8g of polystyrene microspheres, 24ml of carbon disulfide, and 1.06g of anhydrous aluminum trichloride to a 50ml flask, stir with a magnet, and the solution turns yellow, then add 0.3ml of chloroacetyl chloride dropwise, and react in an oil bath at 50°C for 3h. The reaction solution was suction-filtered in anhydrous state, the separated solid matter was quickly poured into glacial hydrochloric acid and stirred, filtered again and washed with deionized water until neutral, finally washed and filtered with absolute ethanol, and dried in a vacuum oven. The chlorine content of the modified microspheres was 12.02%.

[0049] B Chloroacetylated polystyrene coupled PVA

[0050] Swell 1.0 g of chloroacetylated polystyrene microspheres obtained above with 5 ml of DMF overnight, add 35 ml of PVA9K-10K DMF solution to ensure that the PVA concentration in the reaction system is 20 mg / ml, and add tetrabutyl iodide Ammonium 0.76g, pot...

Embodiment 3

[0052] A Bromoacetylation reaction of polystyrene

[0053] Add 1g of polystyrene microspheres, 24ml of carbon disulfide, and 1.5g of anhydrous aluminum trichloride into a 50ml flask, stir with a magnet, and the solution turns yellow, then add 0.4ml of bromoacetyl bromide dropwise, and react in an oil bath at 50°C for 3h. The reaction solution was suction-filtered in anhydrous state, the separated solid matter was quickly poured into glacial hydrochloric acid and stirred, filtered again and washed with deionized water until neutral, finally washed and filtered with absolute ethanol, and dried in a vacuum oven. The bromine content of the modified microspheres was 25.54%.

[0054] B bromoacetylated polystyrene coupled PVA

[0055] Swell 0.6g of bromoacetylated polystyrene microspheres obtained above with 5ml DMF overnight, add 35ml of PVA22K DMF solution, ensure that the PVA concentration in the reaction system is 10mg / ml, add cetyltrimethyl Ammonium bromide 0.44g, potassium hy...

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Abstract

The invention provides a method for preparing surface hydrophilic modified polystyrene materials, and a product thereof, and the method is characterized by grafting and coupling the surface of polystyrene with a layer of hydrophilic macromolecular polyvinyl alcohol (PVA) through a stable chemical bond, particularly performing hydrophilic modification on the surfaces of super-macroporous polystyrene microspheres. The method comprises the following concrete steps: (1) benzene ring of polystyrene is subjected to halogen acetylation or halogen methylation in an organic solvent under the action of acidic catalysts through Friedel-Crafts reaction, and is added to active radical halogen acetyl or halogen methyl; and (2) under alkaline conditions and the action of phase transfer catalyst, Williamson etherification is utilized to couple the hydrophilic PVA to the surface of polystyrene through ether linkage. The method has the advantages of simple operation and mild conditions. A hydrophilic coating is stable, not easy to fall off and rich in hydroxyl. The method has great application potential in biotechnology, particularly the chromatographic separation field.

Description

technical field [0001] The invention relates to a method and a product for surface hydrophilic modification of polystyrene materials. Especially for the hydrophilic modification of the surface of ultra-macroporous polystyrene microspheres, the obtained product is characterized by a high-strength hydrophobic porous skeleton inside, and a layer of hydrophilic macromolecules rich in hydroxyl groups are coupled to the surface (including the inner surface of the pores) Polyvinyl alcohol (PVA), further derivatized as a perfusion chromatographic medium for the rapid separation of biomacromolecules such as proteins. The invention belongs to the field of functional modification of polymer microspheres. Background technique [0002] Nonspecific adsorption of biomacromolecules such as proteins on hydrophobic surfaces exists in many biotechnology applications. For example, the adsorption of antibodies and antigens on a 96-well plate in solid-phase diagnosis will lead to a decrease in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/12C08L25/04G01N30/00
Inventor 马光辉曲剑波苏志国卫强
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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