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Chinese medicine preparation for resisting depression and stress-induced mental disorder, and preparation method thereof

A technology for psychological disorders and traditional Chinese medicine preparations, applied in the field of medicine, can solve problems such as anti-depression and stress-induced psychological disorders that have not yet been seen

Active Publication Date: 2009-05-20
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Tranquilizing traditional Chinese medicine preparations and antidepressant drugs have been seen frequently, but there are no relevant drug literature reports on antidepressant and stress psychological disorders using the method of eliminating phlegm and relieving depression

Method used

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  • Chinese medicine preparation for resisting depression and stress-induced mental disorder, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Take the following proportioning medicinal materials:

[0022] 150 grams of Pinellia, 150 grams of Southern Star, 90 grams of Chenpi, 150 grams of Poria

[0023] Bupleurum 90g, Hang Baishao 180g, Chuan Lian 60g, Angelica 90g

[0024] Stir-fried Atractylodes macrocephala 90g, keel 30g, roasted licorice 60g

[0025] The drug is decocted twice with water, 1.5 hours each time, the decoction is combined, filtered, and the filtrate is concentrated to an appropriate amount. According to the percolation method under "Chinese Pharmacopoeia" (2005 edition) fluid extract and extract, use 70% ethanol as solvent, after soaking for 24 hours, slowly percolate at a speed of 2ml per minute, collect percolation liquid, recovered ethanol, combined with the above aqueous solution and concentrated solution, concentrated to a clear paste with a relative density of 1.35 (75°C), spray-dried to make a dry extract powder, added an appropriate amount of lactose, and mixed well to make 600g of g...

Embodiment 2

[0027] Take the following proportioning medicinal materials:

[0028] 90 grams of pinellia, 90 grams of southern stars, 90 grams of tangerine peel, 90 grams of poria cocos

[0029] Bupleurum 90g, Hang Baishao 90g, Chuan Lian 30g, Angelica 90g

[0030] Stir-fried Atractylodes macrocephala 90g, keel 30g, roasted licorice 60g

[0031] The drug is decocted twice with water, 2 hours each time, the decoction is combined, filtered, and the filtrate is concentrated to an appropriate amount. According to the percolation method under "Chinese Pharmacopoeia" (2005 edition) fluid extract and extract, use 70% ethanol as solvent, after soaking for 24 hours, slowly percolate at a speed of 1ml per minute, collect percolation Liquid, recovered ethanol, combined with the above aqueous solution and concentrated solution, concentrated to a clear paste with a relative density of 1.30 (75°C), spray-dried to make a dry extract powder, added an appropriate amount of lactose, mixed well, sprayed the...

Embodiment 3

[0033] Take the following proportioning medicinal materials:

[0034] 150 grams of Pinellia, 150 grams of Southern Star, 90 grams of Chenpi, 90 grams of Poria

[0035] Bupleurum 90g, Hang Baishao 90g, Chuan Lian 30g, Angelica 90g

[0036] Stir-fried Atractylodes macrocephala 90g, keel 30g, roasted licorice 60g

[0037] The drug is decocted twice with water, 1.5 hours each time, the decoction is combined, filtered, and the filtrate is concentrated to an appropriate amount. According to the percolation method under "Chinese Pharmacopoeia" (2005 edition) fluid extract and extract, use 70% ethanol as solvent, after soaking for 24 hours, slowly percolate at a speed of 2ml per minute, collect percolation liquid, recovered ethanol, combined with the above aqueous solution and concentrated solution, concentrated to a clear paste with a relative density of 1.32 (75°C), spray-dried to make a dry extract powder, added an appropriate amount of lactose, and mixed well to make 480g of gra...

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Abstract

The invention provides a traditional Chinese medicine preparation for resisting depression and stress mental handicap, which is a medicament prepared from traditional Chinese medicines in the following weight proportion: 9 to 15 portions of Pinellia tuberifera preparata, 9 to 15 portions of rhizoma arisaematis preparata, 9 to 15 portions of dried orange peel, 9 to 30 portions of tuckahoe, 6 to 9 portions of radix bupleuri, 9 to 18 portions of white peony root, 3 to 6 portions of rhizoma coptidis, 9 to 15 portions of angelica, 9 to 15 portions of rhizoma atractylodis macrocephalae, 15 to 30 portions of dragon bone, and 6 to 9 portions of honey-fried licorice root. The invention is to provide the traditional Chinese medicine preparation which comprises active ingredients such as Pinellia tuberifera and rhizoma arisaematis and resists depression and stress metal handicap by applying a phlegm-dissolving depression-relieving method as a core rule to resist depression and stress mental handicap based on TCM phlegm syndrome theory; an animal experiment shows that the preparation can shorten the still time of forced swimming of a mouse and has anti-depression effect, and the anti-depression effect is more apparent than fluoxetine; and through the clinical observation, the medicament can eliminate depression state, apparently improve sleeping quality, and relieve anxiety and tension moods. The invention also provides various oral formulations of the medicament and a preparation method.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a traditional Chinese medicine oral preparation for antidepressant and stress-induced psychological disorders and a preparation method thereof. Background technique [0002] Stress disorder is the body's maladaptive response to severe or persistent stress. With the development of social economy and the constant acceleration of the pace of life, the incidence of stress disorders has increased significantly. Sudden major events such as wars, fires, earthquakes, etc., and certain life-threatening diseases such as tumors, stroke, and hemiplegia can all be used as stressors to cause psychological disorders. If not intervened in time, physical symptoms such as headache and insomnia will appear, and about 40%-50% of patients will also experience sleep disturbance. Comorbid depression, anxiety, cardiovascular disease, asthma, etc. can also be comorbid, and comorbid depression can also...

Claims

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Application Information

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IPC IPC(8): A61K36/8888A61P25/24A61K35/02
Inventor 魏品康
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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