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Pharmaceutical composition with function for resisting malignant tumor and preparation method thereof

A technology for malignant tumors and pharmaceutical preparations, applied in the field of drug combinations for the treatment of malignant tumors

Inactive Publication Date: 2012-09-05
刘阳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the application of the total alkaloids of Solanum nigrum and its unilateral or compound preparations in antitumor drugs. There is no preparation of the total alkaloids of Solanum nigrum in China registered with SFDA, and domestic and foreign patents (Chinese patent, Japanese patent) , Korean patent, European patent, U.S. patent, etc.) have no patent protection content similar to the present invention

Method used

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  • Pharmaceutical composition with function for resisting malignant tumor and preparation method thereof
  • Pharmaceutical composition with function for resisting malignant tumor and preparation method thereof
  • Pharmaceutical composition with function for resisting malignant tumor and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0196] Preparation of drug combination of Solanum solanum extract and matrine

[0197] (1) Take the whole herb and / or fruit of Solanum nigrum and add 80% ethanol solution to extract 3 times, 8 times the amount each time, recover the ethanol, concentrate to a relative density of 1.25, add 3 times the amount of 0.1mol / l hydrochloric acid solution in the concentrated solution , fully stirred, refrigerated, filtered, and the filter residue was washed twice with hydrochloric acid solution, combined with the filtrate and washing liquid, and adsorbed with a weak or medium polar resin. After the resin is adsorbed, first wash the resin column / bed with water until the effluent is nearly neutral; then wash the resin column / bed with 0.1mol / l ammonia solution until the effluent is nearly colorless, and then rinse the resin column / bed with 20% ethanol solution Bed until the effluent is nearly colorless. discarded. Then elute with 70% ethanol until the eluate is colorless, collect the elua...

Embodiment 2

[0206] Example 2 Preparation of Injections

[0207] (1) The preparation method of Solanum solanum extract and matrine drug combination with total alkaloid content greater than 50% is the same as that in Example 1.

[0208] (2) Preparation of water injection: take by weighing 10 g of Solanum solanum extract and matrine pharmaceutical composition with total alkaloid content above 50%, dissolve with water for injection, adjust pH value to 7, filter, sterilize, Inspection, packaging, and 1000 aqueous injections were obtained.

[0209] (3) Preparation of transfusion: take by weighing 10 g of the Solanum solanum extract and Kushensu medicinal composition whose total alkaloid content is more than 50%, dissolve it with an appropriate amount of water for injection, and adjust the pH with 0.1mol / l hydrochloric acid When the value reaches 6-7, stir for 30 minutes, add a certain amount of activated carbon, continue to stir for half an hour, filter, pass through a 0.22 μm filter membr...

Embodiment 3

[0211] Example 3 Preparation of solid dosage forms

[0212] (1) The preparation method of Solanum solanum extract and matrine drug combination with the total alkaloid content of Solanum solanum greater than 50% is the same

[0213] Example 1.

[0214] (2) Preparation of tablet: 10 grams of Solanum solanum extract with a total alkaloid content greater than 50% and Kushensu, 100 grams of starch and magnesium stearate as medicinal excipients. Mix evenly, pulverize, sieve, granulate, dry, compress into tablets, inspect, pack, and obtain 10,000 tablets.

[0215](3) Preparation of capsules: take by weighing 100 g of Solanum solanum extract and matrine pharmaceutical composition with total alkaloid content of Solanum nigrum more than 50%, 1000 g of medicinal starch, mix uniformly, pack into No. 2 capsules, each Contains 100mg of pharmaceutical composition.

[0216] (4) Preparation of powder: take by weighing 1000 g of Solanum solanum extract and matrine pharmaceutical composit...

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PUM

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Abstract

The invention discloses a medicine composition with remarkable treatment effect against malignant tumor, small toxic side effect and safe use. The composition consists of an extract of traditional Chinese medicine Solanum nigrum and Sophora alopecuroide, seeds of herba sophorae alopecuroide as a leguminous plant or oxymatrine extracted from roots of kuhseng as the leguminous plant. In the medicine composition, the content of total alkaloids from solanum nigrum of the extract of the Solanum nigrum is more than 50 percent. In the medicine composition, the content of the total alkaloids from solanum nigrum is 1 to 4 weight portions more than 50 percent of the extract of the Solanum nigrum and 1 to 3 weight portions of the oxymatrine, wherein the preferred proportion is that the content of the total alkaloids from solanum nigrum is 3 weight portions more than 50 percent of the extract of the Solanum nigrum and 2 weight portions of the oxymatrine. The invention also discloses a method for preparing the medicine composition.

Description

technical field [0001] The invention relates to a medicine combination for treating malignant tumors. The composition contains the total alkaloids extracted from the traditional Chinese medicine Solanum solanum and the seeds of the leguminous plant Sophora sophora or the root of the leguminous plant Sophora flavescens. Matrine, the pharmaceutical composition has obvious effects on the treatment of malignant tumors, and the invention also provides a preparation method of the pharmaceutical composition. Background technique [0002] Cancer (malignant tumor) in modern society has become one of the main problems that threaten human life and health. The report of the World Health Organization (WHO) shows that according to the current trend of cancer incidence, the incidence of cancer in the world will increase by 50% in 2020, and the global The number of new cancer patients will reach 15 million every year. The medical community urgently needs safe and effective cancer treatment...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/81A61K9/02A61K9/08A61K9/10A61K9/107A61K9/12A61K9/14A61K9/16A61K9/19A61K9/20A61K9/48A61P35/00A61K31/4375
Inventor 杨石李明慧
Owner 刘阳
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