Extracorporeal circulation pool of artificial liver support system
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A technology supporting system and extracorporeal circulation, applied in the field of biomedicine, can solve problems such as lack of material exchange, and achieve the effects of sufficient material exchange, real-time temperature monitoring, and reasonable design
Active Publication Date: 2010-08-25
ZHEJIANG UNIV
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[0003] At present, various types of reactors have been developed at home and abroad, such as: HepatAssist 2000, ELAD, MELS, microcapsule suspension perfusion reactors, etc., but most of them are reinfused into the body after one cycle, lacking sufficient material exchange with cells , or use a wide-mouth bottle as a circulation pool, but it is impossible to avoid the situation that the plasma that has not been metabolized by the liver cells is directly reinfused into the body
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Embodiment 1
[0014] Referring to Fig. 1, the extracorporeal circulation pool of the artificial liver of the present invention is composed of circulation and control. Pipes 7 and 8, circulation tank outlets 10 and 11, return input port 12; the control part includes: box body 13, oxygen inlet 14, opening 15, heating device 16, fan 17, control pipeline 18, and display screen 19.
[0015] The box body 1 is made of thermal insulation transparent plexiglass material. The tops of the hollow fiber tubes 3 and 4 are respectively glued with gum and embedded on the inner wall of the box body 1. The hollow fiber tubes 3 and 4 are each made of 200 500 micron diameter tubes. The air-permeable and waterproof membrane material is composed of hollow fiber tubes. The tops of the hollow fiber tubes 3 and 4 are respectively provided with an inlet 2 and a return input port 12. The lower ends of the hollow fiber tubes 3 and 4 are respectively provided with Outlet 5 and outlet 6, outlet 5 is connected to one end...
Embodiment 2
[0018] With reference to Fig. 1, Fig. 2, Fig. 3, the operation of artificial liver extracorporeal circulation pool of the present invention is as follows: after blood or plasma flows out from reserve body (patient body) 21, enter in the circulation pool 22 through entrance 2, pass through hollow fiber tube 3 Afterwards, temperature and oxygen content all improve to some extent, flow out by output pipe 5 again, flow into outlet 11 through tee pipe 8 and leave circulation pool, enter reactor 23 (can select commercialized hollow fiber reactor or other perfusion type reactor for use) All can be), and then return to the plexiglass box 1 by the return input port 12, after passing through the hollow fiber tube 4, leave the box body 1 from the outlet 6 through the three-way pipe 7 and the outlet 10 to flow out of the circulation pool, and pass through the three-way pipe At 7 o'clock, part of the blood or plasma flows out of the circulation pool 22 from the outlet 10, and is returned to...
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Abstract
The invention relates to an extracorporeal circulation tank of an artificial liver supporting system, which consists of a circulatory part and a control part. The circulatory part is provided with a tank body, an inlet, a hollow fiber pipe, an outlet, a three-way pipe, an outlet of the circulation tank, and a feedback inlet; and the control part is provided with the tank body, an oxygen inlet, anopening, a warming device, a fan, a control pipeline, a display screen and a plastic tube. The hollow fiber pipe is embedded on the inner wall of the tank body, the inlet and the outlet are arranged corresponding to two ends of the hollow fiber pipe, one end of the three-way pipe is connected with an outlet and the other two ends are connected with a peristaltic pump and the outlet of the circulation tank respectively, the upper part of the tank body is provided with the oxygen inlet and the lower part is provided with the opening, and the display screen is arranged on the upper part of the tank body and is connected with the control pipeline. Compared with the prior extracorporeal circulation device, the extracorporeal circulation tank has the function of monitoring temperature, pump speed and blood oxygen content in real time, can realize recirculation for the blood plasma in a reactor, guides the substance exchange between hepatocyte and severe liver blood plasma to be more complete, and improves the efficiency of an artificial liver device. The extracorporeal circulation tank has the advantages of reasonable design, convenient operation and practicality.
Description
technical field [0001] The invention belongs to the field of biomedicine and relates to a device used in biomedicine, which mainly provides extracorporeal circulation for biological and mixed artificial livers or other biological devices. Background technique [0002] Artificial liver support system refers to the use of physical, chemical, and biological devices in clinical treatment to temporarily assist or replace liver function in severe disease, remove various harmful substances, and supplement biologically active substances, so that liver cells can be regenerated until the autologous liver recovers. Or wait for the opportunity for a liver transplant. Can be divided into non-biological type, biological type and hybrid artificial liver support system. Non-biological artificial liver includes: hemodialysis, plasma exchange, plasma adsorption, filtration, etc., focusing on detoxification, but the complex functions of the liver and the increasingly tight source of plasma li...
Claims
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