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Loxoprofen sodium framework tablet

A technology of loxoprofen sodium and matrix tablets, which is applied in the field of medicine, can solve the problems of inconvenient large-scale industrial production and high dosage of hydroxypropyl methylcellulose, achieve quantitative production quality control, be suitable for large-scale industrial production, and improve curative effect Effect

Inactive Publication Date: 2009-01-14
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Loxoprofen sodium is a soluble drug, and only the hydrophilic gel skeleton material hydroxypropylmethylcellulose is used as the sustained-release material. The amount of hydroxypropylmethylcellulose is relatively high, which brings inconvenience to large-scale industrial production

Method used

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  • Loxoprofen sodium framework tablet
  • Loxoprofen sodium framework tablet
  • Loxoprofen sodium framework tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] prescription:

[0036] Loxoprofen sodium 100mg

[0037] Hypromellose K15M 50mg

[0038] Ethyl cellulose 20mg

[0039] Acrylic resin No. II 20mg

[0040] Microcrystalline cellulose 160mg

[0041] Magnesium stearate

[0042] 70% ethanol appropriate amount

[0043] Preparation method:

[0044] Pass loxoprofen sodium, hypromellose K15M, ethyl cellulose, acrylic resin No. II, and microcrystalline cellulose separately through 80 mesh sieve (pulverize if necessary), and weigh the ingredients according to the prescription and mix well , Add loxoprofen sodium, mix well, add 70% ethanol to make soft material, granulate, dry, sizing, add 1% by weight of magnesium stearate, press tablets, and get ready.

Embodiment 2

[0046] prescription:

[0047] Loxoprofen Sodium 90mg

[0048] Hypromellose K15M 60mg

[0049] Ethyl cellulose 20mg

[0050] Acrylic resin No. II 25mg

[0051] Microcrystalline cellulose 155mg

[0052] Magnesium stearate

[0053] 70% ethanol appropriate amount

[0054] Preparation method:

[0055]Pass loxoprofen sodium, hypromellose K15M, ethyl cellulose, acrylic resin No. II, and microcrystalline cellulose separately through 80 mesh sieve (pulverize if necessary), and weigh each excipient according to the prescription and mix well , Add loxoprofen sodium, mix well, add 70% ethanol to make soft material, granulate, dry, sizing, add 4% by weight of magnesium stearate, press tablets, and get ready.

Embodiment 3

[0057] prescription:

[0058] Loxoprofen Sodium 90mg

[0059] Hypromellose K4M 105mg

[0060] Ethyl cellulose 20mg

[0061] Acrylic resin No. II 20mg

[0062] Microcrystalline cellulose 115mg

[0063] Magnesium stearate

[0064] 70% ethanol appropriate amount

[0065] Preparation method:

[0066] Pass the loxoprofen sodium, hypromellose K4M, ethyl cellulose, acrylic resin No. II, and microcrystalline cellulose through an 80 mesh sieve (crush if necessary), weigh the ingredients according to the prescription and mix well , Add loxoprofen sodium, mix well, add 70% ethanol to make soft material, granulate, dry, sizing, add 2% by weight of magnesium stearate, press tablets, and get ready.

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PUM

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Abstract

The invention belongs to the technical field of medicines, particularly relates to a composition containing loxoprofen sodium, and more particularly, the invention relates to a loxoprofen sodium matrix tablet. The loxoprofen sodium matrix tablet is composed of loxoprofen sodium of an active component, hydroxypropyl methylcellulose (HPMC), ethyl cellulose (EC) and acrylics of polymer materials and filling agents. The loxoprofen sodium matrix tablet of the invention has longer action time than a common tablet and reduces the side effects. The invention has simple operation process, low cost and easy control and is suitable for industry large scale production.

Description

Technical field [0001] The present invention belongs to the technical field of medicine, and specifically relates to a composition containing loxoprofen sodium, and more specifically, the present invention relates to a matrix tablet of loxoprofen sodium. Background technique [0002] Loxoprofen sodium is a phenylpropionic acid non-steroidal anti-inflammatory drug, its chemical name is 2-[4-(2-oxocyclopentan-1-ylmethyl)phenyl] sodium propionate dihydrate , The molecular formula is C 15 H 17 NaO 3 ·2H 2 O, the molecular weight is 304.32, and the chemical structure is: [0003] [0004] Loxoprofen sodium has excellent antipyretic, analgesic and anti-inflammatory effects, and is characterized by strong analgesic effects. It can be widely used clinically for rheumatoid arthritis, deformity arthritis, low back pain, frozen shoulder, neck and shoulder syndrome. Anti-inflammatory and analgesic, analgesic and anti-inflammatory after surgery, trauma and tooth extraction, and antipyretic ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/192A61P29/00
Inventor 印春华唐翠吴吉
Owner FUDAN UNIV
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