Biodegradable high molecular nanometer particles, specialty polymer thereof and preparation method thereof

A polymer and block polymer technology, applied in the field of biodegradable polymer nanoparticles, can solve the problems of biosafety and biocompatibility hazards, impossible to achieve a constant rate of drug release, etc., to avoid biosafety And the hidden danger of biocompatibility, the effect of excellent biodegradability and good stability

Inactive Publication Date: 2008-12-31
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] At present, non-spherical nanoparticles are mostly made of metals, metal compounds, small molecular carbon materials or inorganic materials, and individual non-spherical polymer nanoparticles are also made of polystyrene-polyacrylic acid (PS-b-PAA) or polystyrene It is made of non-biodegradable polymer materials such as styrene-polyethylene glycol (PS-b-PEG), so it is not only impossible to achieve constant drug release when used in the biomedical field, but also has great potential Biosafety and Biocompatibility Hazards

Method used

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  • Biodegradable high molecular nanometer particles, specialty polymer thereof and preparation method thereof
  • Biodegradable high molecular nanometer particles, specialty polymer thereof and preparation method thereof
  • Biodegradable high molecular nanometer particles, specialty polymer thereof and preparation method thereof

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Embodiment 1～12

[0039] According to the reaction mass ratio shown in table 1, glycolide, L-lactide, polyethylene glycol (PEG), and the catalyzer (titanium that is the sum of glycolide and L-lactide weight 0.01~0.15%) butyl ester or stannous isooctanoate), mixed uniformly in a polymerization tube, and then reacted at a temperature of 130-180°C for 10-70 hours under 15Pa vacuum conditions to obtain a series of products with different lengths and ratios of hydrophilic / hydrophobic segments. Polymers PLGE-1 to PLGE-12.

[0040] Table 1 Preparation of PLGE polymer

[0041]

[0042] The molecular weight distribution of the above-mentioned PLGE polymer is between 1.5-2.5.

Embodiment 13～24

[0044] PLGE is an amphiphilic block copolymer containing both a hydrophilic segment (PEG) and a hydrophobic segment (PLGA) in the polymer molecule, so PLGE nanoparticles can adopt the unique self-expression of amphiphilic block copolymer molecules. Prepared by emulsification-solvent diffusion self-assembly method. The specific preparation method is as follows: First, dissolve the PLGE polymer in a water-soluble organic solvent to form a PLGE organic phase, and then gradually add the PLGE organic phase to a certain temperature of the water phase at 20-30 ° C, so that the organic solvent naturally diffuses into the water phase , while the hydrophilic PEG segment in the PLGE molecule migrates to the interface and enriches, and finally solidifies to form PLGE nanoparticles with a core-shell structure with the hydrophobic PLGA segment as the core and the hydrophilic PEG segment as the shell. , the particle size range of the nanoparticles is 10-200nm. The water-soluble organic solv...

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Abstract

The invention discloses a biologically degradable macromolecular nano particle, a special polymer thereof and a preparation method thereof. The invention provides poly-(glycolide / lactide)-polyethyleneglycol-poly(glycolide / lactide) with structural formula I :-[(1 / 2GA)m1(1 / 2LA)n1]-b-[(CH2CH2O)p]-b-[(1 / 2GA)m2(1 / 2LA)n2]; m1 and m2 are integers from 10-80; n1 and n2 are integers from 10-90; m is equal to the total of m1 plus m2, n is equal to the total of n1 plus n2, and m / n is equal to 10 / 90-80 / 20; p is an integer from 0-454, and the ratio of the total of m plus n to p is 100:0-400. The preparation method of PLGE particle avoids emulsifier and is simple in process and short in procedure and is suitable for large-scale production. The PLGE particle is of high purity, good medical permeability, biological compatibility and safety and is biologically degradable. The PLGE particle can be dried into powder and is easy to disperse in water without agglomeration; with good storage and using performances, the PLGE particle can satisfy various requirements in biomedicine.

Description

technical field [0001] The invention relates to a class of biodegradable macromolecular nanoparticles with various shapes, special polymers and their preparation methods. Background technique [0002] Nanoparticles generally refer to particles with a particle size ranging from 1 to 100 nm. Due to the extremely small size and large specific surface of nanoparticles, nanoparticles have peculiar physical properties such as small size effect, surface effect, volume effect, quantum size effect, macroscopic quantum tunneling effect, etc. that are not found in general materials, and are obviously different from Bulk materials in general and unique properties of individual molecules. For example, in biomedical applications, because nanoparticles have better physical stability than general microspheres, nano-preparations can have better resistance to heat sterilization and storage stability than general microsphere preparations; because nanoparticles are colloidal systems , so nano...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G81/00C08G63/08C08G63/85C08J3/12
Inventor 王身国张汉威贝建中
Owner INST OF CHEM CHINESE ACAD OF SCI
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