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Biodegradable temperature/pH dual responsiveness aquagel

A temperature-responsive and responsive technology, used in the field of biomedical polymer materials to achieve excellent water absorption

Inactive Publication Date: 2008-12-24
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] As far as our research is concerned, there have been no literature or patent reports on hydrogels based on biodegradable polyphosphates with dual temperature / pH responsive properties.

Method used

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  • Biodegradable temperature/pH dual responsiveness aquagel
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  • Biodegradable temperature/pH dual responsiveness aquagel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 to 4

[0051] 1. Examples 1 to 4 Synthesis of crosslinking agent polyphosphate macromonomer:

Embodiment 1

[0052] Example 1: HEMA-PEOP-Ac (EOP: HEMA: Sn(Oct) 2 =150:5:3) synthesis method

[0053] Place the reaction flask and stir bar in an oven at 120°C for at least 6 hours. After taking it out, plug it tightly with a turn-up rubber stopper, and then use a vacuum oil pump to vacuum while filling with high-purity argon. Repeat several times until the reaction flask is cooled.

[0054] Use a dry syringe to sequentially inject 6.8860g monomer EOP (45.3mmol), 0.1965g initiator HEMA (1.51mmol) and 0.3670g catalyst Sn(Oct) into the bottle. 2 (0.91mmol), then evacuated and filled with high-purity argon three times. Finally, the reaction flask was placed in a 45°C oil bath with a preset temperature. After 3 hours of reaction, the stopper was opened to stop the reaction.

[0055] The crude reaction product was precipitated in a large amount of ice anhydrous ether for three times, and then dried in a vacuum oven at 30°C for 24 hours to obtain 6.0810 g of a colorless transparent viscous product (...

Embodiment 2

[0057] Example 2: HEMA-PEOP-Ac (EOP: HEMA: Sn(Oct) 2 =50:5:3) Synthesis method

[0058] Place the reaction flask and stir bar in an oven at 120°C for at least 6 hours to dry. After taking it out, use a rubber stopper to close it, and then use a vacuum oil pump to vacuum while filling with high purity argon. Repeat several times until the reaction flask cools.

[0059] Use a dry syringe to sequentially inject 1.2170g monomer EOP (8mmol), 0.1042g initiator HEMA (0.8mmol), and 0.1944g catalyst Sn(Oct) into the bottle. 2 (0.48mmol), then evacuated and filled with high-purity argon three times; finally, the reaction flask was placed in an oil bath with a preset temperature of 45°C. After reacting for 3 hours, the stopper was opened to stop the reaction.

[0060] The crude reaction product was precipitated three times in a large amount of ice and anhydrous ether, and then dried in a vacuum oven at 30°C for 24 hours to obtain 1.0760 g of a colorless transparent viscous product (HEMA-PEOP...

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PUM

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Abstract

The invention discloses biodegradable temperature / pH dual response hydrogel and a preparation method thereof. The method comprises the following steps that: a temperature response polyphosphate ester macromonomer is taken as a crosslinking agent, and reacts with a pH sensitive monomer for radical polymerization for 12 to 24 hours at a temperature of between 30 and 50 DEG C, and then the hydrogel is prepared. The hydrogel provided by the invention utilizes temperature sensitive polyphosphate ester to replace the prior temperature sensitive acrylamide polymer, and overcomes the defect that the prior temperature sensitive hydrogel is mostly formed by polymers with poor degradability. The hydrogel provided by the invention has superior water absorption, permeability, biocompatibility, degradability and temperature / pH sensitivity, is a novel artificially synthesized macromolecular hydrogel material, and is widely used in biomedicine and other prospects, for example, the hydrogel can be taken as a biomedical material such as a medicine slow release carrier or a tissue engineering cell culture support and so on.

Description

Technical field [0001] The invention belongs to the technical field of biomedical polymer materials, and specifically relates to a type of biodegradable temperature / pH dual responsive hydrogel and a preparation method thereof. Background technique [0002] Smart hydrogels, also known as sensitive hydrogels, refer to those that can sense small changes or stimuli in the external environment (such as temperature, pH, light, and biological molecules, etc.), and can produce corresponding changes in physical structure and chemical properties A type of polymer hydrogel. Due to the intelligence of sensitive hydrogels, it is possible to be applied in many fields, especially in the sustained release of drugs, the separation and purification of proteins, the entrapment of active enzymes, and artificial muscles. Its research has also received extensive attention from scholars at home and abroad. [0003] Among the many sensitive hydrogels, temperature or pH sensitive hydrogels have become a ...

Claims

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Application Information

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IPC IPC(8): C08F290/06C08G79/04
Inventor 倪沛红何金林王赛张明祖
Owner SUZHOU UNIV
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