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Chinese medicine preparation containing Hippochaete ramosissimum total flavones and use for preparing medicament for treating hepatitis

A technology of traditional Chinese medicine preparations and knotweed, which is applied in the direction of drug combinations, antiviral agents, and medical raw materials derived from ferns/filamentous plants, etc.

Inactive Publication Date: 2008-12-17
KUNMING SHENGHUO PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are few reports on the application in liver diseases

Method used

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  • Chinese medicine preparation containing Hippochaete ramosissimum total flavones and use for preparing medicament for treating hepatitis
  • Chinese medicine preparation containing Hippochaete ramosissimum total flavones and use for preparing medicament for treating hepatitis
  • Chinese medicine preparation containing Hippochaete ramosissimum total flavones and use for preparing medicament for treating hepatitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] The preparation of the total flavonoids extract of embodiment 1 knot grass

[0046] Take the knotweed and extract it three times with 70% ethanol under reflux, each time for 2 hours, collect the extract three times, filter, recover the ethanol under reduced pressure until there is no alcohol smell, add water to dilute to 1ml / g crude drug, and filter. The filtrate was passed through the D101 macroporous adsorption resin, washed with water until the effluent was colorless, the resin was eluted with 50% ethanol, the eluate was collected, the ethanol was recovered, and dried to obtain a solid extract with a total flavonoid content of 55%.

Embodiment 2

[0047] The preparation of the total flavonoids injection of embodiment 2 Jiejiecao

[0048] Get the total flavonoids extract of Saccharomyces chinensis prepared by the method of embodiment 1, add water for injection to dissolve, decolorize with activated carbon, filter, sterilize and fill into 10ml / branch after sterilization, so that each contains 0.1g of total flavonoids of Saccharomyces spp. For intravenous injection.

Embodiment 3

[0049] The preparation of the lyophilized needle of the total flavonoids of the 3 knots of embodiment 3

[0050] Get the total flavonoids extract of Saccharomyces chinensis prepared by the method of Example 1, add water for injection to dissolve, decolorize with activated carbon, filter, sterilize, fill, and freeze-dry, so that each tube contains 0.3 g of total flavonoids of Saccharomyces spp.

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Abstract

The invention relates to a Chinese materia medica preparation with total flavonoids of equisetum ramosissimum desfontaines, a preparation method thereof, and the application thereof to preparation of medicines for treating hepatic diseases. The Chinese materia medica preparation with the total flavonoids of equisetum ramosissimum desfontaines of the invention consists of 0.3-85% of the extract of the active ingredient of equisetum ramosissimum desfontaines and 15-99.7% of a preparation which consists of pharmaceutical adjuvants and has various pharmaceutically acceptable dosage forms such as injection, oral solid preparation, cream and oral liquid, wherein, the content of the main active ingredient namely the total flavonoids of equisetum ramosissimum desfontaines in the extract of the active ingredient of the equisetum ramosissimum desfontaines is not less than 50%. The invention also discloses a preparation method of the Chinese materia medica preparation. The preparation of the invention has obvious antiviral function, good and unique effect on acute and chronic infectious hepatitis, and is safe and free from toxicity, provides a novel medicine with remarkable curative effect and convenient use for patients with hepatitis. The preparation has the advantages of promoting the recovery of the patients with hepatitis, lowering the death rate of the hepatitis, and reducing the onset of the liver cancer.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a traditional Chinese medicine preparation containing total flavonoids of knotweed, a preparation method and the application of the preparation as a medicine for treating liver diseases. Background technique [0002] At present, the incidence of various types of liver diseases is relatively high all over the world, especially in developing countries. Although there is no national epidemic report in China, the survey from some areas shows that the incidence rate has exceeded 5%. The large-scale hepatitis A epidemic in Shanghai in the 1980s also shows the severity of viral liver disease. Some people estimate that there are as many as 500 kinds of drugs for the treatment of liver diseases in the world, but in fact there is still no one that can really cure it. Many patients with liver disease develop from chronic hepatitis to nodular cirrhosis due to lack of effective...

Claims

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Application Information

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IPC IPC(8): A61K36/11A61P1/16A61P31/12
Inventor 蓝桂华陈蓬方松兰锋
Owner KUNMING SHENGHUO PHARMA GRP
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