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Puerarin sustained-release dropping pills and preparation method thereof

A technology of puerarin and angina pectoris, applied in the field of pharmaceutical preparations, can solve the problems of out-of-control drug release time, decreased bioavailability, and increased drug-related substances, and achieve the effects of reducing the number of medications, improving bioavailability, and accelerating dissolution and absorption

Inactive Publication Date: 2008-09-24
北京博智绿洲医药科技有限公司
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AI Technical Summary

Problems solved by technology

The analysis may be affected by factors such as the characteristics of the drug itself, the preparation method, and the external environment, which may cause changes in the structure of puerarin itself and the crystal form of the substance after the drop pills are formed, thereby increasing the number of drug-related substances and making the release time out of control. Decreased bioavailability, therefore, offsets to some extent the unique advantages of dripping pills

Method used

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Examples

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Comparison scheme
Effect test

Embodiment Construction

[0036] Now with several groups of specific examples, the preparation method of the puerarin sustained-release dripping pills of the present invention is further described:

[0037] First group:

[0038] Based on the total weight of 100g, weigh 30% of matrix PEG4000, 25% of PEG6000, 23% of stearic acid, 7% of glyceryl monostearate, 2% of stabilizer vitamin C, and 13% of raw material puerarin; Heat and stir in the heating container to melt, add the corresponding proportion of puerarin, stir well, then add the stabilizer vitamin C and stir evenly, under the condition of heat preservation, drop the molten or mixed liquid medicine into the container containing dimethyl In the condensation column of silicone oil, the temperature during heating and melting is 55°C, the temperature of the upper part of the condensate is 35°C, and the temperature of the bottom is -2°C; take it out after forming.

[0039] The obtained product has a cumulative release rate of 35-55% in 2 hours, a cumula...

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Abstract

The invention discloses a medicine used for curing the diseases such as coronary heart disease, angina, miocardial infarction, retinal artery or vein occlusion and sudden deafness, etc. and a preparation method thereof. The invention aims at making up the deficiency of the prior art and provides a puerarin sustained-release pill preparation. In the constituents adopted by the prior art, the puerarin sustained-release pill related by the invention utilizes hydrophilic framework material and hydrophobic framework material as stroma and is added with stabilizing agent vitamin C, so as to effectively overcome the defects of the prior art and ensure that the medicaments do not have apparent change relating to the material contents within the valid storing period; furthermore, the puerarin sustained-release pill has the advantages of enough medicine release, controllable medicine releasing time, few times needed by the patient to take the medicine, long time for taking effect and high bioavailability, and is suitable for clinic and family.

Description

technical field [0001] The invention relates to a medicine for treating diseases such as coronary heart disease, angina pectoris, myocardial infarction, retinal artery or vein occlusion, sudden deafness and a preparation method thereof, and belongs to the field of pharmaceutical preparations. Background technique [0002] Puerarin is a monomer extracted and separated from the dry root of the leguminous plant Pueraria mirifica. It belongs to isoflavone compounds. Its Chinese name is puerarin, and its English name is Puerarin. For 4', 7'-dihydroxy, 8-β-D glucose isoflavone. [0003] Puerarin has β-receptor blocking effect, can improve heart and brain blood circulation, reduce myocardial oxygen consumption, resist platelet aggregation, protect vascular endothelial cells and scavenge free radicals. Arteriovenous obstructive disease has a good therapeutic effect. [0004] It can be seen from a large number of existing reports that puerarin is used in the treatment of coronary h...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K31/7048A61P9/10A61P9/14A61P7/02
Inventor 曲韵智
Owner 北京博智绿洲医药科技有限公司
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