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Dosage form containing levorotation gossypol as active component

A technology of L-gossypol and active ingredients, applied in the field of compound pharmaceuticals for the treatment of gynecological diseases

Inactive Publication Date: 2008-09-24
刘德强
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The L-isomer has been shown to be an effective optical isomer for oral antifertility, while the D-isomer is ineffective

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach

[0018] 1. The preparation method of capsules with L-gossypol as active ingredient

[0019] (1) Prescription for the preparation of capsules or enteric-coated capsules

[0020] L-Gossypol 10g Potassium Chloride 250g Vitamin B 1 10g

[0021] Vitamin B 6 10g starch 54.4g dextrin 37.8g

[0022] A total of 1000 capsules were made

[0023] Each capsule contains L-gossypol 10mg

[0024] According to the prescription, the compound drugs such as L-gossypol are mixed evenly, granulated, dried and granulated, and after passing the inspection, they are divided into empty capsules or jejunum-coated capsules to obtain the product.

[0025] (2) Preparation prescription of soft capsules with L-gossypol as active ingredient

[0026] L-Gossypol 10g Potassium Chloride 250g

[0027] Vitamin B 1 10g Vitamin B 6 10g

[0028] Gelatin solution prescription gelatin 100g water 130g

[0029] Get gelatin and add appropriate amount of water to make it absorb water and ...

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PUM

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Abstract

The invention relates to a pharmaceutical preparation taking levorotatory gossypol as active ingredient, in particular to a compound preparation which contains the medicine such as levorotatory gossypol, potassium chloride, vitamin B1 and vitamin B6, etc. and is used for curing gynecological disease. The compound preparation comprises an oral solid preparation and an injection.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a medicine with L-gossypol as an active ingredient, in particular to a medicine containing L-gossypol, potassium chloride, vitamin B 1 , Vitamin B 6 Compound medicines such as medicines for treating gynecological diseases are made into capsules or oral liquids or tablets or powders or pills or granules or injections. Background technique [0002] Gossypol has been clinically proven as a male birth control drug, and it has also been confirmed by a large number of pharmacology, toxicology and clinical experiments as a treatment for gynecological diseases such as uterine fibroids and endometriosis. Chinese scholar Huang Liang et al first completed the resolution of racemic gossypol. It has been proven that the L-isomer is an effective optical isomer for oral anti-fertility, while the D-isomer is ineffective. Animal experiments have shown that the curative effect of L-gossypol in t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/11A61P15/00A61P35/00
Inventor 刘德强
Owner 刘德强
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