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Zanthoxylum dissitum Hemsl medicinal materials discrimination method

A technology of single-sided acupuncture and medicinal materials, which is applied in the field of medicine, can solve the problems of rare and few studies on the active ingredients of single-sided acupuncture medicinal materials.

Active Publication Date: 2008-09-17
ZHUZHOU QIANJIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Single-sided acupuncture is not a standard medicinal material issued by the Pharmacopoeia and the Ministry. It is rare to use this medicinal material in current Chinese patent medicines, and there is no Chinese patent medicine that uses single-sided acupuncture as the main component for quality control. Therefore, the effectiveness of single-sided acupuncture medicinal materials Little research has been done on ingredients

Method used

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  • Zanthoxylum dissitum Hemsl medicinal materials discrimination method
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  • Zanthoxylum dissitum Hemsl medicinal materials discrimination method

Examples

Experimental program
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Effect test

Embodiment 1

[0033] The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention. Embodiment 1 single sided needle medical material for testing sample

[0034] Zanthoxylum dissitum Hemsl. is the dry root and stem of Zanthoxylum dissitum Hemsl. The medicinal materials were provided by Hunan Zhuzhou Qianjin Pharmaceutical Co., Ltd., a total of 30 batches, numbered 1, 2, 3, ..., 28, 29, 30. See Table 1:

[0035] Table 1 Single-sided needle medicinal materials for testing samples

[0036] sample number

Embodiment 2

[0037] The preparation of embodiment 2 test samples

[0038] After the medicinal materials are crushed, pass through a 40-mesh sieve, take 1.0g of each batch of medicinal medicinal powders, accurately weigh them, put them in a 50ml round bottom flask, add 30ml of petroleum ether, heat and reflux for 30min, discard the petroleum ether liquid, evaporate the residue to dry up the solvent, and add Methanol 30ml was heated and refluxed twice, each time for 1h, filtered while hot, combined twice, evaporated to dryness, the residue was dilute to 2ml with methanol, used as the test solution, and filtered through a 0.45μm microporous filter before HPLC analysis. Membrane filtration.

Embodiment 3

[0039] The selection of embodiment 3 reference object

[0040] After the single-sided needle medicinal material was extracted by the above method, multiple chromatographic peaks appeared through HPLC analysis. Since there is no standard product for the exclusive component of single-sided needle, a stable Appearing chromatographic peaks (Peak No. 6, R t 34min) as a reference (structure has not yet been identified) for fingerprint analysis and evaluation, after systematic comparative analysis, it is proved that this method is feasible.

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Abstract

The invention relates to a discrimination method of Zanthoxylum dissitum Hemsl medical material, comprising establishing HPLC standard fingerprint of Zanthoxylum dissitum Hemsl medical material; measuring the fingerprint of the measured sample of the Zanthoxylum dissitum Hemsl medical material using the same method and comparing the fingerprint of the measured sample of the Zanthoxylum dissitum Hemsl medical material and the standard fingerprint of Zanthoxylum dissitum Hemsl medical material to screen the qualified Zanthoxylum dissitum Hemsl medical material in line with the standard fingerprint of Zanthoxylum dissitum Hemsl medical material. The process of establishing the HPLC standard fingerprint of Zanthoxylum dissitum Hemsl medical material comprises: preparing the sample solution and acquiring the HPLC standard fingerprint of Zanthoxylum dissitum Hemsl medical material by determing the common fingerprint features by comparing the fingerprintsof 30 batches of the Zanthoxylum dissitum Hemsl medical material at the conditions that: chromatographic column: Kromasil RP-C18 4.6mm*250mm, 5um; mobile phase: acetonitrile-0.2%triethylamine phosphate solution; using gradient elution: 0 min-10min-30min-70min; the ratio by volume of acetonitrile and 0.2%triethylamine phosphate solution is 5:95-10:90-10:90-40:60; detection wave:280nm. The invention provides a new method for quality control and discrimination of the Zanthoxylum dissitum Hemsl medical material.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a method for identifying medicinal materials of single-sided needles. Background technique [0002] The modernization of traditional Chinese medicine is one of the most popular research directions in the development of contemporary traditional Chinese medicine, and has become a hot spot in the medical circles at home and abroad. Among them, the modernization of quality standards for Chinese medicinal materials and proprietary Chinese medicines is an important part of the modernization of Chinese medicines. Due to the wide variety of Chinese herbal medicines, the different medication habits in different regions, the simple records of ancient herbal medicines, misrepresentation and misuse, and the evolution of medicines, etc., the confusion of Chinese herbal medicines with different names, homonyms and different substances, and genuine and non-genuine products are very serious. More genera...

Claims

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Application Information

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IPC IPC(8): G01N30/86G01N30/88G01N30/02
Inventor 左之文王振勇滕晖朱大安祝晨陈
Owner ZHUZHOU QIANJIN PHARMA
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