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Ligusticum dhuanxiong oil micro-emulsion and preparation thereof

A technology of chuanxiong oil and microemulsion, applied in the field of medicine, can solve the problems of unstable thermodynamics, complicated preparation process, easy stratification, flocculation, phase inversion or rupture and rancidity, etc. Effectiveness of Utilization and Efficacy

Inactive Publication Date: 2008-09-17
四川珍珠制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, ordinary emulsion is a thermodynamically unstable heterogeneous system, which is easy to stratify, flocculate, phase invert or rupture and become rancid, and is not easy to store, and the preparation process is complicated.

Method used

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  • Ligusticum dhuanxiong oil micro-emulsion and preparation thereof
  • Ligusticum dhuanxiong oil micro-emulsion and preparation thereof
  • Ligusticum dhuanxiong oil micro-emulsion and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1 Chuanxiong oil microemulsion soft capsule

[0019] Chuanxiong oil microemulsion contains 0.005 grams of Chuanxiong oil, 4015 grams of Tween, 6 grams of propylene glycol in every 100 ml of emulsion, and the rest is purified water or water for injection. Put it in a plastic tank and mix it evenly, then heat the mixture to 75°C, mix it evenly, vacuumize it, filter it, keep it warm, and press it in a soft capsule making machine. Then put the soft capsule in the setting machine to finalize the shape. After washing, the soft capsules are dried at about 30°C for 12 hours.

Embodiment 2

[0021] Chuanxiong oil microemulsion contains 10 grams of Chuanxiong oil per 100 ml of emulsion, 6010 grams of Tween, 1.5 grams of propylene glycol, and the rest is purified water or water for injection. Other steps are as described in Example 1.

Embodiment 3

[0023] Chuanxiong oil microemulsion contains 0.005 grams of Chuanxiong oil, 8018 grams of Tween, 0.003 grams of isopropanol in every 100 ml of emulsion, and the rest is purified water or water for injection. Other steps are as described in Example 1.

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Abstract

The invention discloses a rhizoma ligustici wallichii oil microemulsion preparation and the preparation method, which adopts rhizoma ligustici wallichii oil as main pharmaceutical component and comprises surface-active material and co-emulsifier. The rhizoma ligustici wallichii oil microemulsion preparation can be made into various forms with various routes of administration. The range of particle size of the adopted O / W microemulsion for the rhizoma ligustici wallichii oil microemulsion is less than 300nm (especially less than 150nm). The rhizoma ligustici wallichii oil microemulsion preparation has the advantages of ability to effectively improving the bioavailability and therapeutic effect, safety and convenience.

Description

technical field [0001] The invention relates to the field of medicine, in particular to Chuanxiong oil microemulsion and a preparation method thereof. Background technique [0002] Chuanxiong is one of the most commonly used traditional Chinese medicines in clinical practice. It is often used to treat various blood disorders in clinic. A large number of studies have been conducted on the effect and mechanism of Rhizoma Chuanxiong in promoting blood circulation and removing blood stasis in China. It has been confirmed that Rhizoma Chuanxiong can improve brain and peripheral microcirculation, significantly increase cerebral blood flow, inhibit platelet activation, reduce red blood cell and platelet aggregation, and treat experimental cerebral ischemia. Histomorphology and brain function are protective. In recent years, studies have found that volatile oil from rhizome of ligusticum Chuanxiong, 1), especially the phthalide compounds in it, play a greater role in the pharmacolo...

Claims

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Application Information

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IPC IPC(8): A61K36/236A61K9/107A61K9/00A61K9/10A61K9/12A61K9/48A61P7/02A61P9/10A61K125/00
Inventor 蔡勤梁隆
Owner 四川珍珠制药有限公司
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