Biocompatibile monodisperse nano polymer carrier and its preparation and medicine-carrying method

Abstract

The invention relates to a monodisperse nano-polymer carrier with biological compatibility and a method for preparation and carrying drug thereof. Firstly, a reversible addition fragmentation chain transfer (RAFT) polymerization method is used for preparing amphiphilic block copolymers with smaller polydispersity index, wherein the hydrophilic segment is methylacryoyloxyethyl phosphorylcholine (MPC) and the hydrophobic segment is n-butyl methacrylate (BMA). Then through the method of solvent evaporation, the amphiphilic block copolymers are used for preparing nano-polymer micelle, drugs are encapsulated in the micelle through physical action, thus obtaining the monodisperse nano-polymer carrier system with good biological compatibility.

Description

technical field [0001] The invention relates to a biocompatible monodisperse nanometer polymer drug-carrying system and a preparation method thereof, belonging to the technical field of pharmaceutical engineering. Background technique [0002] Many antineoplastic drugs (such as paclitaxel, doxorubicin, methotrexate, etc.) have very low solubility in water, and they also have strong toxic and side effects. Therefore, the direct use of such antineoplastic drugs has very low efficacy. and cause greater harm to the human body. In order to solubilize hydrophobic drugs and achieve drug sustained release, researchers have extensively studied many drug delivery systems, such as liposomes, microspheres, surfactant micelles, etc., but these systems still have many shortcomings, such as: lipid Surfactants and microspheres have large particle sizes and are easily phagocytosed by the human reticuloendothelial system (RES); surfactant micelles have a high critical micelle concentration (...

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Problems solved by technology

[0002] Many antineoplastic drugs (such as paclitaxel, doxorubicin, methotrexate, etc.) have very low solubility in water, and they also have strong toxic and side effects. Therefore, the direct use of such antineoplastic drugs has very low efficacy. and cause greater harm to the human body

In order to solubilize hydrophobic drugs and achieve drug sustained release, researchers have extensively studied many drug delivery systems, such as liposomes, microspheres, surfactant micelles, etc., but these systems still have many shortcomings, such as: lipid Surfactants and microspheres have large particle sizes and are easily phagocytosed by the human reticuloendothelial system (RES); surfactant micelles have a high critical micelle concentration (CMC) and lack good anti-dilution properties, etc.

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