Method for preparing highly water-soluble cydiodine

Abstract

The invention discloses a preparation method of a high water-soluble cydiodine, which belongs to pharmacy technology field. Quickly putting the iodine solution into Beta- cyclodextrin saturated solution and then mixing constantly until the solution cools to below 40 DEG C. Then naturally precipitating the cooled cydiodine solution and pouring the supernatant out and leaving the sediment when the precipitation completes. Or separating the cooled cydiodine solution via centrifugation to separate the sediment and water, and then putting the sediment to the oven to bake to powder and then sift out; in addition, spray drying the cooled west ground solution to get dry powder of cydiodine is also feasible. Put the dry cydiodine powder to the oven to bake for a certain period and then mixing well, and the high water-soluble cydiodine will be formed. The high water-soluble cydiodine prepared by the method has the advantages of having fast coating speed, high water-soluble, good disinfect effect and stable quality.

Description

technical field [0001] The invention relates to a preparation method of highly water-soluble cedi iodine, which belongs to the technical field of pharmacy. Background technique [0002] Infectious diseases are one of the important factors that endanger the health of humans, animals and plants. In order to eliminate infection, we must not only kill pathogenic microorganisms that invade the body, but also eliminate pathogenic microorganisms in the environment to protect the health of humans, animals and plants, and this task must be completed by disinfection. Disinfection can eliminate pathogenic microorganisms from the source of infectious diseases and block the spread of pathogenic microorganisms, thereby protecting humans, animals and plants. Disinfection can be carried out by physical methods or chemical methods, and in the face of the epidemic of large infectious diseases, chemical disinfection is the most important means of disinfection. Chemical disinfection is the us...

AI Technical Summary

Problems solved by technology

In addition, in the above patents, the process of coating iodine with β-cyclodextrin is relatively long, that is, cediiodine can only be obtained after a certain period of time at the coating temperature.

[0004] The above patented methods can prepare cedi iodine with stable quality and high iodine content, but the solubility of cedi iodine prepared by these methods is very low, and the soluble amount in 100ml of water at 20°C is not more than 0.01g, which belongs to insoluble substances

Simultaneously, the cediodine prepared by these methods has other disadvantages and is not suitable for large-scale environmental disinfection.

For example, in the four patents of Japan and the patents of the Chinese Academy of Military Medical Sciences, I 2 The aqueous solution is made of KI as a cosolvent, and the amount of KI is the same as that of I 2 The dosage ratio is all very high, and KI is two-thirds of the iodine dosage in the patent of Japan, and KI is 0.2~10 times of the iodine dosage in the patent of my country Academy of Military Medical Sciences, because the price of KI and I 2 Similarly, KI has no bactericidal effect in cedi iodine, and the use of small doses can increase the solubility of iodine in water, but the use of large doses will only increase the cost of cedi iodine, which is not suitable for large-scale environmental disinfection

However, in the patent obtained by Chen Wenzheng of my country, only ethanol is used for the dissolving of iodine. The Sidi iodine prepared by this process not only has low solubility, but also has poor stability of the iodine molecules released by Sidi iodine in water due to the lack of dissolution aid of potassium iodide. , easy to volatilize and cause the concentration in water to decrease

[0005] As can be seen from the above patents: with I 2 With β-cyclodextrin coating ratio as 1: 1 calculation, the theoretical content of iodine molecules in cedi iodine is about 18.27%, because the solubility of cedi iodine prepared in the above patents is all lower than 0.01g, even if cedi iodine is dissolved in The iodine molecules coated after water are all dissociated, and the concentration of iodine molecules in the cedi iodine solution cannot reach 18.27mg / L, and the killing concentration of iodine to most bacteria will be higher than 50mg / L, so the above The cediodine prepared by the patented method will not be used as a large-scale disinfection