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Use of common stonecrop herb and salidroside in stem cell oriented differentiation to hepatocyte lineage

A technology of salidroside and directed differentiation, applied in medical preparations containing active ingredients, animal cells, digestive system, etc.

Active Publication Date: 2010-08-11
北京瑞草堂三圣(汤阴)药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no report that rhodiola and salidroside can induce the directed differentiation of adult stem cells into hepatic cells

Method used

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  • Use of common stonecrop herb and salidroside in stem cell oriented differentiation to hepatocyte lineage
  • Use of common stonecrop herb and salidroside in stem cell oriented differentiation to hepatocyte lineage
  • Use of common stonecrop herb and salidroside in stem cell oriented differentiation to hepatocyte lineage

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Embodiment 1

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Abstract

The invention relates to a rhodiola rosea and a rhodioside application for inducing stem cells to directionally differentiate into hepatocytes, in particular to a compound inducer of the rhodioside and cell growth factor FGF-4 used for inducing mesenchymal stem cells to directionally differentiate into hepatocytes. The rhodiola rosea develops the new application of rhodiola, which induces mesenchymal stem cells and other stem cells to directionally differentiate into hepatocytes in vitro, and provides the effect of the rhodiola rosea and the rhodioside on inducing the adult stem cells to directionally differentiate into hepatocytes, which is beneficial to further research of the in vivo stem cells transplantation for treating acute or chronic hepatic injury and middle-advanced liver disease field, and provides the basic for new drug development.

Description

(1) Technical field The invention relates to the application of rhodiola rosea, especially salidroside, in inducing stem cells to differentiate into hepatic cells. (2) Background technology Rhodiola is a plant of the genus Rhodiola (Rhodiola L.) of the Crassulaceae family. It is a perennial herb or subshrub plant, mainly distributed in the Himalayas in the northern hemisphere, northwest Asia and North America at an altitude of 1,600 to 4,000 meters. area. Rhodiola rosea has a long history of medicinal use, known as "golden ginseng" and "immortal grass". According to the Pharmacopoeia, Rhodiola rosea is the dry root and rhizome of Rhodiola grandiflora of the sedum family plant. It is sweet, bitter, and flat in nature. Burnout and shortness of breath. Modern pharmacological research shows that the biological activity of rhodiola rosea is inseparable from its various chemical components. Salidroside (salidroside) is a natural product isolated and purified from Rhodiola ros...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N5/06A61K36/41A61P1/16C12N5/071C12N5/0775
Inventor 李连达欧阳竞锋吴理茂乔洪翔
Owner 北京瑞草堂三圣(汤阴)药业有限公司
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