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Syringopicroside tablet and preparation technique thereof

The invention relates to a technology for syringoside and a preparation process, which is applied to the field of syringoprein tablets, and can solve the problems of poor stability of the finished product, large dosage, dark color and the like, and achieve the effects of fast onset, high curative effect and small side effects.

Inactive Publication Date: 2008-07-09
李永吉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the preparations using clove leaves as raw materials have been used clinically, they are difficult to enter the international market because of their large dosage, dark color, many impurities, and poor stability of finished products.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Syringin: 0.005 g

[0028] Sodium carboxymethyl starch 0.005 g

[0029] Medicinal starch: 0.01 g

[0030] Dextrin: 0.01g

[0031] Magnesium stearate: 0.0001 g

[0032] The process is as follows:

[0033] (1) Sieve syringin, sodium carboxymethyl starch, starch, and dextrin through a 100-mesh sieve, and magnesium stearate through a 40-mesh sieve;

[0034] (2) Calculate the feeding amount according to the proportion, accurately weigh the raw and auxiliary materials, put them into the mixer and mix for 4-10 minutes, add 10% starch slurry, stir for 2-8 minutes, and make soft materials;

[0035] (3) Granulate in the granulator, the wet granules are loose and complete;

[0036] (4) When drying, the sieve should be evenly spread and the thickness should be appropriate. Ventilate and dry at 60-70°C, and turn once every half an hour after drying. The moisture content of the particles should be controlled between 6-8%;

[0037] (5) Use a 16-mesh sieve to granulate, gradually...

Embodiment 2

[0042] Syringin: 0.1 g

[0043] Low substituted hydroxypropyl cellulose 0.1g

[0044] Medicinal starch: 0.1 g

[0045] Dextrin: 0.1 g

[0046] Magnesium stearate: 0.0005 g

[0047] The process is as follows:

[0048] (1) Sieve syringin, sodium carboxymethyl starch, starch, and dextrin through a 100-mesh sieve, and magnesium stearate through a 40-mesh sieve;

[0049] (2) Calculate the feeding amount according to the proportion, accurately weigh the raw and auxiliary materials, put them into the mixer and mix for 4-10 minutes, add 10% starch slurry, stir for 2-8 minutes, and make soft materials;

[0050] (3) Granulate in the granulator, the wet granules are loose and complete;

[0051] (4) The sieve should be spread evenly, with appropriate thickness, ventilated and dried at 60-70°C, and turned once every half an hour after drying, and the moisture content of the particles should be controlled between 6-8%;

[0052] (5) Use a 16-mesh sieve to granulate, gradually add slip ...

Embodiment 3

[0057] Syringin: 0.02g

[0058] Sodium carboxymethyl starch 0.025 g

[0059] Medicinal starch: 0.04 g

[0060] Dextrin: 0.05g

[0061] Magnesium stearate: 0.0002 g

[0062] The process is as follows:

[0063] (1) Sieve syringin, sodium carboxymethyl starch, starch, and dextrin through a 100-mesh sieve, and magnesium stearate through a 40-mesh sieve;

[0064] (2) Calculate the feeding amount according to the proportion, accurately weigh the raw and auxiliary materials, put them into the mixer and mix for 4-10 minutes, add 10% starch slurry, stir for 2-8 minutes, and make soft materials;

[0065] (3) Granulate in the granulator, the wet granules are loose and complete;

[0066] (4) The sieve should be spread evenly, with appropriate thickness, ventilated and dried at 60-70°C, and turned once every half an hour after drying, and the moisture content of the particles should be controlled between 6-8%;

[0067] (5) Use a 16-mesh sieve to granulate, gradually add slip material...

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PUM

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Abstract

The present invention relates to a syringopicroside preparation and a preparation technology thereof. The preparation contains the syringopicroside with the weight portion of 1 percent to 50 percent and the auxiliary material with the weight portion of 99 percent to 50 percent. The prepared preparation has high biological utilization degree, stable quality and good curative effect. The drug has the bacteriostasis effect with wide spectrum and has good curative effect towards upper respiratory tract infection, enteritis, bacillary dysentery, acute and chronic bronchitis, acute gastroenteritis, mastitis and hepatitis. The present invention has simple and stable preparation technology and is fit for the industrialization production.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation and a preparation method thereof. Specifically, it is a syringin monomer preparation, especially a syringin tablet. The preparation is made from syringpicroside monomer as a raw drug and appropriate auxiliary materials through a certain preparation process. Background technique [0002] At present, clove leaves are the dried leaves of lilac, clove or carnation of Osmanthus family plants. The effective parts are obtained through extraction and refining. Its antibacterial effect is obvious, and it has strong inhibitory ability to bacteria of 24 genera. It is clinically used for enteritis, bacillary dysentery and other intestinal infectious diseases and has received good therapeutic effect. Although the preparation using clove leaf as raw material has been used clinically, it is difficult to enter the international market because of its large dosage, dark color, many impurities, and poo...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K36/185A61K47/40A61K9/28A61K9/20A61K9/48A61K9/16A61P31/04A61P1/12A61P11/00A61P1/16A61P15/14A61K127/00
CPCY02A50/30
Inventor 李永吉杨海玲
Owner 李永吉
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