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New use of polyhydroxy galloyl-beta-D-glucose derivatives

A technology of glucose derivatives and galloyl group, applied in the field of medicine, can solve problems such as no anti-Helicobacter pylori and the like, and achieve the effects of good anti-Helicobacter pylori activity, low toxic and side effects, and low cost

Inactive Publication Date: 2008-07-02
CHIA TAI TIANQING PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Polyhydroxygalloyl-β-D-glucose derivatives are a class of known compounds with a wide range of sources, and their various biological activities have been reported successively, such as scavenging free radicals, antioxidant activity, anti-SARS virus infection activity, anti-HCV NS3 protease activity, apoptosis-inducing activity, angiotensin transferase inhibitor activity, cell cycle inhibitor activity, and activity as a tyrosine kinase inhibitor, but so far, no anti-pyloric helix has been found in the world Any reports of activity against bacillus

Method used

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  • New use of polyhydroxy galloyl-beta-D-glucose derivatives

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Embodiment 1 prepares compound 2 by geranium

[0064] Take 2000 g of Geranium dahuricum, crush it, add 8 times the amount of 40% ethanol, and reflux three times for 2 hours each time. Filter off the medicinal residues and combine the extracts for 3 times, concentrate under reduced pressure to obtain 280g of extract, add an appropriate amount of water to dissolve, and then use petroleum ether (500ml × 4), ethyl acetate (500ml × 4), n-butanol (500ml × 4 ) for extraction. The ethyl acetate extracts were combined, concentrated to dryness under reduced pressure, applied to a silica gel column in batches (100-200 mesh silica gel G for silica gel), followed by chloroform, chloroform:methanol=10:1, chloroform:methanol=8:1, Chloroform:methanol=5:1, chloroform:methanol=2:1, methanol was eluted and detected by thin layer chromatography. The chloroform:methanol=5:1 eluents were combined and concentrated to dryness. The resultant was repeatedly chromatographed on a gel column (Se...

Embodiment 2

[0065] Embodiment 2 prepares compound 1 and 5 by gallnut

[0066] After crushing 500 g of Galla chinensis, 2000 ml of 50% ethanol-water solution was cold soaked at room temperature to extract three times, soaked for 24 hours each time, and the extracted filtrate was concentrated under reduced pressure to evaporate ethanol to obtain 260 g of crude extract. The crude extract was extracted sequentially with petroleum ether (500ml×4), chloroform (500ml×4), ethyl acetate (500ml×4), and n-butanol (500ml×4), and divided into several parts. The ethyl acetate parts were combined, concentrated and evaporated to dryness, and applied to a gel column (Sephadex LH-20) in batches, followed by water, methanol: water = 2: 8, methanol: water = 4: 6, methanol: water = 6: 4 , methanol: water = 8: 2, methanol, acetone for gradient elution, and detection by thin layer chromatography to obtain 6 components.

[0067] The 6 components were subjected to polyamide column decompression column chromatogr...

Embodiment 3

[0068] Embodiment 3 prepares compound 3 by Rhodiola angustifolia

[0069] 3kg of Rhodiola angustifolia was crushed, soaked and extracted with 10000ml 80% ethanol three times, soaked for one week each time, the crude extract was concentrated under reduced pressure, and after the ethanol was evaporated, 300g of extract was obtained, dissolved in appropriate amount of water, and then washed with petroleum ether (600ml×5 ), chloroform (600ml×5), ethyl acetate (600ml×5), n-butanol (600ml×5) extraction. The organic layer was evaporated to dryness under reduced pressure to obtain 23 g of petroleum ether, 17 g of chloroform, 48 g of ethyl acetate, and 100 g of n-butanol. Ethyl acetate and n-butanol were partly applied to a polyamide column, and the obtained fraction was further purified by means of gel column chromatography to obtain pure compound 3.

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Abstract

The invention relates to a usage of polyhydroxy galloyl-Beta-D-glucose derivatives or the medicinal salts in anti-helicobacter pylori, and the invention also relates to a usage of drugs which contain at least one extract of polyhydroxy galloyl-Beta-D-glucose derivative used for the prevention and / or treatment of diseases which are caused by helicobacter pylori.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to the new application of polyhydroxy galloyl-β-D-glucose derivatives, in particular to polyhydroxy galloyl-β-D-glucose derivatives or an extract containing at least one of the derivatives in Use in anti-Helicobacter pylori. Background technique [0002] In 1983, Australian scholars Warren and Marshall first isolated Helicobacter pylori (Hp) from gastric mucosa. A large number of studies have shown that: Helicobacter pylori infection is related to many diseases that seriously endanger human health, such as chronic active gastritis, gastric ulcer, duodenal ulcer, gastric mucosa-associated lymphoid tissue (MALT) malignant lymphoma and gastric cancer Wait. Data show that about more than 50% of the world's population is infected with Helicobacter pylori, especially in developing countries, where the adult infection rate reaches 60-80%. In 1994, the International Agency for Research on ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7024A61P1/04
Inventor 李洋张喜全李新祝
Owner CHIA TAI TIANQING PHARMA GRP CO LTD
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