Concentration extract of gymenma sylvestre compound plant drug dissolving and preparing method thereof
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A technology of Gymnema sylvestre and botanical medicine, applied in the field of medicine, can solve the problems of affecting extraction operation, no increase in activity, increase in activity, etc., and achieve the effects of high content of active ingredients, low toxicity and improved hypoglycemic activity
Inactive Publication Date: 2008-06-18
SHENYANG PHARMA UNIVERSITY
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]Because it contains a large amount of triterpene saponins, foams are often produced during the extraction process of Gymnema unifolia, which affects the routine extraction operation, and there is a research report on refining gymnemic acid for eliminating foams [Foreign Medicine, Phytomedicine Volume 1998.13 (4 )], in fact, many medicinal plant extracts have increased activity and increased toxicity after refining, and even the phenomenon that the activity has not increased, but the indications have changed, and the toxicity has also increased.
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Embodiment 1
[0043] Using the extraction process of the present invention, the following prescriptions can be made into high-activity hypoglycemic and weight-loss extracts, and the medicine can be selected within the range of proportioning,
[0044] Prescription 1 scoop Gymnema 9g
[0045] Coptis 4g
[0046] Scutellaria baicalensis 3g
[0047] Gardenia 6g
[0048] The hypoglycemic activity is shown in Table-1, and the parameters are shown in Table-3
[0049] Determination of active ingredients in the prescription: see Figure-1 for the HPLC spectrum of Coptidis Rhizoma, and Figure-2 for the HPLC spectrum of Astragalus membranaceus.
[0050] The TLC identification results of Gymnema Fangzhongshao are shown in Figure-3.
[0051] The HPLC fingerprint of this recipe is shown in Figure-7.
Embodiment 2
[0053] Prescription 2
[0054] Gymnema 9
[0055] coptis 4
[0056] Astragalus 5
[0057] Gardenia 4
[0058] The hypoglycemic activity is shown in Table-1, and the parameters are shown in Table-3
[0059] Determination of active ingredients in the prescription: see Figure-1 for the HPLC spectrum of Coptidis Rhizoma, and Figure-2 for the HPLC spectrum of Astragalus membranaceus.
[0060] See Figure-3 for the TLC identification results of Gymnema Fangzhong, and Figure-4 for the TLC identification results of Fangzhong Rhodiola. The HPLC fingerprint of this recipe is shown in Figure-6
[0061] Table-3 spoon root rattan compound extract and the experimental result of preparation
[0064] 1. The conditions for the determination of the effective components of Coptis chinensis in the compound recipe are as follows: Chromatographic column: KromasilC 18 (150mm*4.60mm, 5μl) column temperature 37°C, mobile phase:...
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Abstract
The invention belongs to the field of medical technology, which relates to an enrichment extract of Gymnema Sylvestre compound plant medicine dissolution and a preparation method. The invention utilizes an extraction technology for the compound extract of medicinal plants comprising a plurality of triterpene saponin, and the emulsification which is generated by the saponin in water and light-concentration alcohol to promote the maximum extraction for various semi-polarity and non-polar active ingredients of the other traditional Chinese medicines in the extractive compound. Compared with other traditional Chinese medicines, compound extractive of botanical drug formula and Gymnema Sylvestre unilateral extract, the Gymnema Sylvestre compound has the advantages that: the biological activity is enhanced; the toxicity of the extract is lowered, and the physical traits of the extract can be improved, so that the Gymnema Sylvestre compound can be prepared into standardized and modern preparation in small dose. Such combined extract can be taken as a drug and health product for the treatment of hyperglycemia, hyperlipemia and adiposity.
Description
technical field [0001] The present invention relates to the field of medical technology, to be precise, it is a technology for preparing compound extracts composed of other traditional Chinese medicines and herbal medicines, and the products and preparations of the extracts, that is, the component-enriched extracts of the eluted herbal medicine components and preparation method. Specifically, it is an enriched extract and a preparation method of the eluate of Gymnema compound herbal medicine. The extracts of such compositions are raw materials for medicines and health care products. Background technique [0002] Gymnema is a traditional Chinese medicine, and Gymnema contains a large amount of active ingredients of triterpene saponins. It has biological activities such as lowering blood sugar, lowering blood fat, and suppressing appetite (weight loss). It is a traditional herbal medicine for treating diabetes in India [Nakano Long, a secret medicine native to South Asian pl...
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