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Prune tree extract and preparation method and application thereof

A technology for extracts and plum trees, applied in the field of plant extracts, can solve the problems of inability to guarantee the effectiveness, safety, stability, poor processing adaptability, and low content of active ingredients of medicines.

Active Publication Date: 2012-01-11
HANGZHOU U MATE TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This methanol crude extract has not been separated and purified, has high impurity content, low active ingredient content, deep color, strong hygroscopicity, difficult preservation, and poor processing adaptability
At the same time, the variety of plum tree used is not clear. When the extract is used in the field of medicine, if the source of the plant is not sure, the three basic requirements of drug effectiveness, safety and stability cannot be guaranteed.

Method used

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  • Prune tree extract and preparation method and application thereof
  • Prune tree extract and preparation method and application thereof
  • Prune tree extract and preparation method and application thereof

Examples

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Effect test

preparation example Construction

[0083] Preparation method of plum tree extract

[0084] The plum tree extract provided by the present invention can come from the whole plum tree, preferably the non-fruit part thereof. Said non-fruit parts include flowers, branches, stems, roots, or leaves. Plum blossoms are mainly taken from unfruited flowers, which are hand-picked and dried in the sun, fried or dried for later use; plum branches can be pruned vegetative branches in spring, pruned branches in autumn, or the branches of plum trees cut down and dried in the sun. , cut and broken for later use; plum leaves are generally collected in summer and autumn and dried in the sun for later use; plum stems and plum roots come from felled plum trees.

[0085] The plum tree raw material that the present invention adopts can carry out pretreatment, also can not through pretreatment. The preferred raw material is 10-20 mesh chips with a water content below 10%.

[0086] The plum tree extract containing 0.5-50% squalene pr...

Embodiment 1

[0167] Plum Blossom Extract

[0168] Use the flowers of Prunus mume ‘Da Ye Qing’ from Xiaoshan, after collecting and drying, crush them into a coarse powder of about 10 meshes, take 1.5kg and put them in CO 2 Extraction in a supercritical extraction kettle.

[0169] Extraction conditions: extraction pressure 35MPa, extraction temperature 60°C, separation temperature 40°C, separation pressure 4MPa, circular dynamic extraction for 2 hours, and 72g of plum blossom fat-soluble extract was obtained in the separation kettle [Dietmate TM (Trademark of Hangzhou Youmate Technology Co., Ltd.)-F01].

[0170] According to GC-MS analysis, it mainly contains long-chain alkanes, polyolefins, VE, phytosterols and triterpenoids, and the content of the characteristic compound squalene (squalene) in the fat-soluble effective part is the mass fraction 1.04%. The results are shown in Table 1 and figure 1 .

[0171] The raffinate was taken out from the extraction kettle, and the raffinate was ...

Embodiment 2

[0177] Plum Branch Extract

[0178] Xiaoshan Prunus mume 'Xi Ye Qing' branches were collected, dried, and crushed into a 10-mesh coarse powder, and 1.5 kg was extracted in a supercritical extraction kettle.

[0179] Extraction conditions: the extraction pressure is 30MPa, the extraction temperature is 55°C, the separation temperature is 45°C, the separation pressure is 4MPa, and the dynamic extraction is cycled for 2h to obtain 64.5g of plum branch fat-soluble extract (Dietmate TM -B01).

[0180] According to GC-MS analysis, it mainly contains long-chain alkanes, polyolefins, VE, phytosterols and triterpenoids, and the content of the characteristic compound squalene (squalene) in the fat-soluble effective part is the mass fraction 4.87%. The results are shown in Table 1 and figure 2 .

[0181] The raffinate was taken out from the extraction kettle, and the raffinate was extracted with 30% ethanol aqueous solution under heat reflux.

[0182] Extraction condition: temperat...

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Abstract

The invention discloses a plum extract containing 0.5-50wt% of squalene. The plum extract mainly comes from liposoluble effective parts and / or water-soluble effective parts from non-fruit part of plum. The invention also provides the preparation method of the plum extract, Liposoluble effective part is obtained through extracting of super-criticality CO2 fluid or nonpolarity organic solvent; the residue of the super-criticality fluid or nonpolarity solvent extract is extracted by alcohol-water solution to obtain the water-soluble effective part. The invention discloses the composition containing plum extract and also discloses application of the plum extract.

Description

technical field [0001] The present invention relates to the field of plant extracts. More specifically, it relates to effective parts extracted from non-fruit parts (flowers, branches, leaves) of plum trees, their preparation methods and uses. Background technique [0002] Plum is a plant of the genus Prunus in the family Rosaceae (Rosaceae), and its scientific name is Prunus mume Sieb.Et Zucc. In horticultural cultivation, plum is divided into flower plum and fruit plum, and fruit plum is divided into white plum, green plum and red plum. [0003] WO00 / 39249 (PCT / JP99 / 07285) discloses a medicinal plum extract and a composition containing the extract, which discloses the following content: "Using 5 times the volume of methanol, from the stems and leaves of plum The extract is prepared from the nuts and plum blossoms of plum, plum, and has antioxidative effect, gastric mucosal damage inhibitory effect, aldose reductase inhibitory effect, blood sugar level rise inhibitory effe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/736A61P1/00A61P3/04A61P3/06A61P7/00A61P9/12A61P9/10A61P17/14A61P1/04A61P35/00A61P37/04A61P37/08A61P39/06C07C7/10C07C67/58C07D311/30C07J9/00C07J63/00A61K135/00A61K133/00A61K127/00
CPCY02P20/54
Inventor 张英陆柏益吴晓琴张泳华石嘉怡潘慧惠董跃杰
Owner HANGZHOU U MATE TECH
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