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Affinity vinyl cyanide base co-polymer superfine fibre film preparation method and application

An acrylonitrile-based copolymer, acrylonitrile-based technology, applied in chemical instruments and methods, membrane technology, semi-permeable membrane separation and other directions, to achieve the effect of simple and feasible immobilization method, good stability and durability, and high specific surface area

Inactive Publication Date: 2008-05-28
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Publication No. CN 1358783 discloses the technology of using 4-azidobenzoic acid bifunctional cross-linking agent to chemically bond chitosan on the surface of the substrate under the action of ultraviolet light. Whether the method is active to the substrate The group is not required, but the disadvantage is that it can cause the bulk crosslinking of chitosan itself

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The acrylonitrile / allylamine copolymer (viscosity-average molecular weight is 80,000) that mass fraction is 4% is dissolved in the dimethylacetamide solvent (being the mass percent of acrylonitrile / allylamine copolymer in dimethylacetamide Concentration is 4%), under the condition that the spinning voltage is 20 kilovolts, the spinneret solution flow rate is 0.5 ml / hour, and the receiving distance is 15 centimeters, electrospinning is carried out to prepare acrylonitrile with a diameter of 98 ± 14 nanometers Base copolymer microfiber membrane.

[0024] Dissolve chitosan with a viscosity-average molecular weight of 7000 in an acetic acid-sodium acetate buffer solution of pH 5.0, stir at room temperature for 24 hours, and prepare a homogeneous transparent solution with a mass fraction of 5 mg / ml; at 25°C, add 0.1 10 milliliters of acrylonitrile-based copolymer microfiber membranes were immersed in 10 milliliters of pH in 6.0 volume fractions of 1% glutaraldehyde aqueous s...

Embodiment 2

[0026] The acrylonitrile / allylamine copolymer (viscosity-average molecular weight is 80,000) that mass fraction is 4% is dissolved in the dimethyl sulfoxide solvent, is 20 kilovolts at spinning voltage, spinneret solution flow rate is 0.5 ml / Electrospinning is carried out under the conditions of 1 hour and a receiving distance of 15 cm, and an acrylonitrile-based copolymer ultrafine fiber membrane with a diameter of 98 ± 14 nm is prepared.

[0027] Dissolve chitosan with a viscosity-average molecular weight of 7000 in acetic acid-sodium acetate buffer solution of pH 5.0, stir at room temperature for 24 hours, and form a homogeneous transparent solution with a mass fraction of 10 mg / ml; 0.1 gram of acrylonitrile-based copolymer microfiber membrane is immersed in 10 milliliters of pH and is 6.0 in the glutaraldehyde aqueous solution of 5% by volume fraction, activates 12 hours, and the fiber membrane after the activation uses a large amount of buffer solution (buffer with dissol...

Embodiment 3

[0029] The acrylonitrile / methallylamine copolymer (viscosity average molecular weight is 240,000) that mass fraction is 5% is dissolved in the dimethylformamide solvent, is 12 kilovolts at spinning voltage, spinneret solution flow rate is Electrospinning was carried out under the conditions of 1.0 ml / hour and a receiving distance of 15 cm to prepare an acrylonitrile-based copolymer ultrafine fiber membrane with a diameter of 190±20 nm.

[0030]Dissolve chitosan with a viscosity-average molecular weight of 7000 in an acetic acid-sodium acetate buffer solution with a pH of 5.0, stir at room temperature for 24 hours, and form a uniform transparent solution with a mass fraction of 5 mg / ml; at 25°C, add 0.1 10 milliliters of acrylonitrile-based copolymer microfiber membranes were immersed in 10 milliliters of pH in 6.0 volume fractions of 1% glutaraldehyde aqueous solution, and activated for 12 hours. Consistent) rinse, filter dry, then put into chitosan solution and react for 10 h...

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Abstract

The invention discloses the preparation method of the ultra fine fiber membrane of an affinity acrylonitrile base copolymer. The acrylonitrile base copolymer is dissolved in solvent to form solution and then electrostatic spinning is conducted to prepare the fiber membrane. The mass percentage of the acrylonitrile base copolymer in the solution is two to eight percent; the spinning voltage of the electrostatic spinning is six to twenty five kv; the flow velocity of spinneret solution is 0.5 to 2.0 ml per hour with the deposition distance ranging from eight to twenty centimeters. The acrylonitrile base copolymer is acrylonitrile / allylamine copolymer, acrylonitrile / methyl allylamine copolymer, acrylonitrile / acrylamide copolymer or acrylonitrile / methacrylamide copolymer with the viscosity-average molecular weight being eighty to three hundred thousand; the solvent is one or various kinds which are mixed with random percentages of dimethyl sulfoxide, dimethyl formyl ammonia or dimethyl acetyl ammonia. After the glycan of the fixed shell of a chemical bond at the surface of the membrane, the membrane is used for separating and purify protein with simple operation, good chemical stability and low cost.

Description

technical field [0001] The invention relates to a preparation method and application of a fiber membrane, in particular to a preparation method and application of an affinity acrylonitrile-based copolymer superfine fiber membrane. Background technique [0002] Chitosan is the deacetylation product of chitin. Due to its good biocompatibility, biodegradability and antibacterial properties, it has a wide range of applications in the fields of biomedicine, pharmacy, food, agriculture, and wastewater treatment. A large number of amino groups that exist on chitosan make it easy to combine with ligands. It is a good affinity material and can be applied to affinity separation (such as US Patent 4970001), separation and purification of proteins (such as US Patent US 5993661), immobilization of cells and enzymes (such as the Chinese patent literature with publication number CN 1285403 and US Patent US 4094743) and the like. However, chitosan is a kind of alkaline polysaccharide, whi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D71/40B01D69/08B01D71/82
Inventor 徐志康车爱馥黄小军
Owner ZHEJIANG UNIV
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