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Astragalus essence effervescent tablets and preparation method thereof

A technology of effervescent tablets and Astragalus membranaceus, applied in the field of traditional Chinese medicine pharmaceuticals, can solve the problems of large packaging volume, affecting the efficacy of drugs, and inconvenient carrying, and achieve the effect of simple process, convenient carrying and taking, and sweet and pleasant taste

Inactive Publication Date: 2008-05-21
NANJING HAILING TRADITIONAL CHINESE MEDICINE RES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Astragalus is rich in polysaccharides, polypeptides, amino acids and other substances through 10% to 50% (V / V) ethanol percolation, and alcohol precipitation and other processes are required in oral preparations, resulting in the removal of astragalus polysaccharides by precipitation and affecting the efficacy of drugs. Disadvantages such as large packaging volume makes it inconvenient to carry

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] The preparation of Radix Astragali extract powder: 5Kg of Radix Astragali powder, add 3 times of 10% (V / V) ethanol impregnation after 24 hours, start percolation, control percolation speed 300ml / min, collect the percolation liquid of 8 times of amount, concentrate To Baume degree 30 (measured at 60°C), get 50ml of concentrated solution, evaporate to dryness, and measure the paste yield of 23.8%, add 800g of dextrin to the concentrated solution according to dry paste: dextrin=1: 0.5, mix evenly, 65 ℃ and dried under reduced pressure, and the water content of the dry paste was measured to be 2.6% (actually measured value).

[0044] Raw material consumption table

[0045] Prescription amount (1 tablet) (g) Sample amount (1000 tablets) (g)

[0046] Astragalus extract powder 0.435 435

[0047] Citric acid 1.063 1063

[0048] Sodium bicarbonate 0.967 967

[0049] Sodium carboxymethyl starch 0.058 58

[0050] Pregelatinized starch 0.29 290

[0051] Aspartame 0.029 29

...

Embodiment 2

[0063] The preparation of Radix Astragali extract powder: 5Kg of Radix Astragali powder, add 4 times of 30% (V / V) ethanol impregnation after 24 hours, start percolation, control percolation speed 280ml / min, collect the percolation liquid of 7 times of amount, concentrate To Baume degree 31 (measured at 60°C), get 50ml of concentrated solution, evaporate to dryness, and measure the paste yield of 24.1%, add 1200g of dextrin to the concentrated solution according to dry paste: dextrin=1: 0.8, mix evenly, 65 ℃ and dried under reduced pressure, and the water content of the dry paste was measured to be 2.1% (actually measured value).

[0064] Raw material consumption table

[0065] Prescription amount (1 tablet) (g) Sample amount (1000 tablets) (g)

[0066] Astragalus extract powder 1.225 1225

[0067] Citric acid 0.605 605

[0068] Sodium bicarbonate 0.55 550

[0069] Sodium carboxymethyl starch 0.35 350

[0070] Pregelatinized starch 0.525 525

[0071] Stevia 0.07 70

[00...

Embodiment 3

[0083] The preparation of Radix Astragali extract powder: 5Kg of Radix Astragali powder, add 4 times of 50% (V / V) ethanol impregnation after 24 hours, start percolation, control percolation speed 250ml / min, collect the percolation liquid of 6 times of amount, concentrate To Baume degree 31 (measured at 60°C), take 50ml of the concentrated solution, evaporate to dryness, measure and obtain a paste rate of 24.0%, add 1500g of dextrin to the concentrated solution according to dry paste: dextrin=1:1, mix evenly, 65 ℃ and dried under reduced pressure, and the water content of the dry paste was measured to be 2.5% (actually measured value).

[0084] Raw material consumption table

[0085] Prescription amount (1 tablet) (g) Sample amount (1000 tablets) (g)

[0086] Astragalus extract powder 1.5 1500

[0087] Citric acid 0.262 262

[0088] Sodium carbonate 0.238 238

[0089] Sodium carboxymethyl starch 0.375 375

[0090] Pregelatinized starch 0.05 50

[0091] Aspartame 0.05 50 ...

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Abstract

The invention relates to a radix astragali essence effervescent tablet containing the radix astragali and a preparing method thereof. The radix astragali essence effervescent tablet is made by applying the extract powder which is made by the Chinese traditional medical radix astragali as raw material, adding effervescent agent, disintegrating agent, filling agent, flavor correcting agent and lubricant to conduct a wet method, making grains and tabletting. The invention is characterized by convenience, rapidness and novelty and is unlimited by water temperature when in use, The effervescent tablet contains no cane sugar and has sweet taste, thus improving the adaptability of the patient and assuring the curative effect. The invention adopts the technique of combining the effervescent agent and the disintegrating agent to prepare the effervescent tablet, improves the disintegration of the effervescent tablet, reduces the use of the effervescent agent and lowers the cost. Moreover, the invention has simple technique and strong controllability and facilitates the quality control of the products.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and relates to an effervescent tablet containing astragalus extract of astragalus, and also relates to a preparation method of the effervescent tablet. Background technique [0002] Radix Astragali Effervescent Tablets, which are mainly made from traditional Chinese medicine Radix Astragali (Radix Astragali), originated from the secondary development of traditional Chinese medicine of the variety "Radix Astragali Oral Liquid" produced by Yangzijiang Pharmaceutical Group. The main function is to nourish blood and nourish qi, consolidate the root and stop sweating, and is used for qi deficiency and blood deficiency, spontaneous sweating due to surface deficiency, weakness of limbs, lack of energy or protracted illness and weakness, and weak spleen and stomach. [0003] Astragalus is rich in polysaccharides, polypeptides, amino acids and other substances through 10% to 50% (V / V) ...

Claims

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Application Information

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IPC IPC(8): A61K36/481A61K9/20A61K9/46A61K47/34A61K47/40A61P1/14A61P7/06A61K125/00A61K47/36
Inventor 许益清何盛江严军李林燕张现涛贾树田
Owner NANJING HAILING TRADITIONAL CHINESE MEDICINE RES CO LTD
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