Huperzine dropping pills and preparation method thereof

A technology of huperzine A and A dripping pills, which is applied in the field of medicine, can solve the problems of cumbersome production process, inaccuracy, drug loss dosage, etc., and achieve the effects of simple production conditions, less dosage, and convenient carrying and taking

Inactive Publication Date: 2008-05-14
ZHEJIANG WANBANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This patent document provides a drop pill preparation and its preparation method. The preparation method adopted by the drop pill is to add huperzine A and the carrier into the molten matrix after ultra-micronization, but because the dosage of huperzine A is extremely small , it is very easy to cause drug loss and inaccurate dosage during production operations, and special expensive ultrafine pulverization equipment is used, the production process is cumbersome, a small amount of dust is generated, and there are certain defects in the technology. defect, to be corrected

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0015] prescription

[0016] Huperzine A 50mg

[0017] Macrogol 6000 10g

[0018] Macrogol 4000 20g

[0019] Polysorbate 80 0.3g

[0020] Ethanol 1ml

[0021] Makes 1000 pills

[0022] Preparation method: Dissolve huperzine A in ethanol and fully dissolve it to become huperzine A dispersed ethanol solution, add it to the matrix composed of molten polyethylene glycol 6000, polyethylene glycol 4000, and polysorbate 80, fully Stir until uniform, use simethicone oil as coolant, drop into pellets at 15°C, rub the pellets, and dry to obtain.

example 2

[0024] prescription:

[0025] Huperzine A 50mg

[0026] Macrogol 4000 30g

[0027] Polysorbate 80 0.3g

[0028] Ethanol 1ml

[0029] Makes 1000 pills

[0030] Preparation method: Dissolve huperzine A in ethanol and fully dissolve it to become huperzine A dispersed ethanol solution, add it to the matrix composed of molten polyethylene glycol 4000 and polysorbate 80, stir well until uniform, and mix with two Use methyl silicone oil as a cooling agent, drop it into pellets at 10°C, rub the pellets, and dry them to obtain the product.

example 3

[0032] prescription

[0033] Huperzine A 50mg

[0034] Macrogol 6000 30g

[0035] Polysorbate 80 0.3g

[0036] Ethanol 1ml

[0037] Makes 1000 pills

[0038] Preparation method: Dissolve huperzine A in ethanol and fully dissolve it to become huperzine A dispersed ethanol solution, add it into the matrix composed of molten polyethylene glycol 6000 and polysorbate 80, stir well until uniform, add two Use methyl silicone oil as a cooling agent, drop it into pellets at 15°C, wipe the pellets, and dry them to obtain the product.

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PUM

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Abstract

The invention relates to a huperzine A dropping pill and a preparation method, which is characterized in that: the huperzine A is dissolved through proper solvent and then added into the matrix by the dispersion dropping method, is agitated evenly and condensed to be the pill.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a huperzine A dripping pill and a preparation method thereof. Background technique [0002] Huperzine A is a highly efficient and highly selective central acetylcholinesterase inhibitor extracted from Chinese herbal medicine Huperzia serrata. It has selective inhibitory effect on true acetylcholinesterase, easily passes through the blood-brain barrier, and has a long acting time. It has the function of promoting memory reproduction and enhancing memory retention. In 1995, it was first developed and applied in China to treat senile dementia, benign memory impairment and other diseases. Clinical evaluation shows that compared with similar drugs, huperzine A has the advantages of quick onset, easy penetration of the blood-brain barrier, long acting time, and convenient oral application. [0003] The current market sales mainly include huperzine A tablets, capsules, and...

Claims

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Application Information

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IPC IPC(8): A61K31/435A61K9/20A61K47/34A61K47/44A61P25/00A61P25/28A61K47/10
Inventor 赵守明谢正生林红
Owner ZHEJIANG WANBANG PHARMA
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