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Controlled release compositions comprising an antipsychotic agent

A technology of antipsychotic drugs and derivatives, applied in the field of quetiapine or its salts, which can solve the problems of patient compliance and increased health care costs

Inactive Publication Date: 2008-02-13
ELAN PHRMA INT LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, this multiple dosing can lead to issues related to patient compliance and increased healthcare costs

Method used

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Examples

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Embodiment Construction

[0011] Formulations similar to those disclosed herein are disclosed and claimed in US Patent Nos. 6,228,398 and 6,730,325 to Devane et al., both of which are incorporated herein by reference.

[0012] The present invention relates to a formulation for the delivery of antipsychotic drugs in a pulsatile or bimodal manner. The antipsychotic drug is selected from the group consisting of dibenzothiazepine-derivatives such as quetiapine or a salt thereof (eg quetiapine fumarate); lithium; and divalproex. The formulation contains (A) a "first component" which contains the first described group of antipsychotic drugs; and (B) at least one "subsequent component" which contains a subsequent group of antipsychotic drugs and which allows for the Improved release. The agent in each population may be the same or different from the agent contained in the other population and present in the same or different amount as the other population.

[0013] In one embodiment of the invention substan...

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Abstract

The invention relates to a formulation for the treatment of acute manic episodes associated with Bipolar I Disorder comprising an antipsychotic agent selected from the group consisting of: a dibenzothiazepine derivative; lithium; and divalproex. The formulation comprises a first component which comprises a first population the antipsychotic agent and at least one subsequent component which comprises a subsequent population of the antipsychotic agent and which allows for the modified release of the agent. The combination of the first and the subsequent components in operation deliver the antipsychotic agent in a pulsed or controlled manner over a period of up to twenty-four hours.

Description

field of invention [0001] The present invention relates to a novel formulation for the controlled delivery of an antipsychotic drug selected from the group consisting of: dibenzothiazepine-derivatives such as quetiapine or a salt thereof; lithium; sodium valerate. In particular, the formulation is useful in the treatment of patients with acute manic episodes associated with bipolar I disorder. Background technique [0002] Quetiapine fumarate (2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol Maleate (2:1) (salt)) is an antipsychotic drug belonging to a new chemical family, dibenzothiazepine-derivatives, and was developed by AstraZeneca Pharmaceuticals, L.P. of Ilmington, Delaware, USA. With the registered trademark SEROQUEL _ sell. It is an antagonist of multiple neurotransmitter receptors in the brain: serotonin 5HT 1A and 5HT 2 Receptors (respective IC 50 =717&148nM), dopamine D 1 and D 2 Receptors (respective IC 50 =1268&329nM), histamine H ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D281/02A61K9/24A61K9/22A61K9/48A61K9/52
CPCA61K9/5084A61K33/00A61K31/4745A61K9/4808A61K45/06A61P25/18A61K2300/00A61K9/48
Inventor G·利弗西奇S·詹金斯
Owner ELAN PHRMA INT LTD
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