Method for preparing cation exchange resin of calcium polystyrolsulfon acid

Abstract

The invention relates to a polystyrene sulfonic acid sodium cation exchange resin which is copolymerization prepared by the styrene-two ethylene benzene, through the compound which contains calcium ion transform, it purifies to the polystyrene sulfonic acid calcium resin, the compound which contains calcium ion is composed of calcium ion and its balance ion, the complexing agent, the acid alkalinity regulator and water. The balance ion is the chlorine ion; the complexing agent is: one kinds, two kinds or more than two kinds of the ethylene diamine four ethanoic acid, the second two support three amine five ethanoic acid, the ammonia three acetic acid, the citric acid and the calcium salt or sodium salt; the acid alkalinity regulator is hydrochloric acid and sodium hydroxide or hydrogen calcium oxide and so on abio-acid and alkali. The invention technical index has achieved to the standard of outward appearance,the calcium content, the potassium exchange quantity and the impurity (ammonium, heavy metal, arsenic, styrene and sodium) in the Japanese pharmacopoeia (JP14 e), the residual 1,2- dichloroethane content conforms to the standard about the organic solvent in the Chinese pharmacopoeia (2005 editions).

Description

technical field [0001] 本发明涉及用苯乙烯-二乙烯苯共聚制备的聚苯乙烯磺酸钠阳离子交换树脂,经含钙离子的组合物转化、纯化成聚苯乙烯磺酸钙树脂,其技术指标达到日本药典(JP14 e)规定的外观、钙含量、钾交换量和杂质(铵、重金属、砷、苯乙烯和钠)的标准,残留的1,2-二氯乙烷含量符合中国药典(2005版)关于有机溶剂残留规定的标准。 Background technique [0002] 聚苯乙烯磺酸钠阳离子交换树脂是第一代降钾树脂。钠树脂和人体内的钾交换,树脂吸附钾放出钠,过多的钠在体内也会产生不良影响。而钙树脂和钾交换放出钙,可以避免过多的钠产生的不良影响。因此聚苯乙烯磺酸钙阳离子交换树脂是第二代降钾树脂。对于需要进行血透析治疗的高血钾症患者,借助于聚苯乙烯磺酸钙进行辅助治疗,可以延长透析周期、减少透析次数。既減少了患者的痛苦也减轻了患者的经济负担,同时可以避免在体内产生过多的钠产生的不良影响。这种聚苯乙烯磺酸钙是一种内服药物,因此对纯度有特殊的技术要求。 [0003] 现有技术中有“一种浅色高纯聚苯乙烯磺酸钠阳离子交换树脂的制备方法”20061003853.6,“浅色高纯聚苯乙烯磺酸钠阳离子交换树脂的制备方法”200610038354.0;“聚苯乙烯磺酸钠阳离子交换树脂的制备方法”200710020018.8,提出了解决了符合日本药典(第14版)规定的聚苯乙烯磺酸钠的制备工艺。 Contents of the invention [0004] 本发明的目的是在上述专利申请的基础上,用所述工艺漂白、纯化的聚苯乙烯磺酸钠阳离子交换树脂经含钙离子的组合物转化、纯化制得技术指标达到日本药典(JP14 e)规定的外观等标准,残留的1,2-二氯乙烷含量符合中国药典(2005版)关于有机溶剂残留规定的标准的聚苯乙烯磺酸钙阳离子交换树脂。 [0005] 实现上述发明目的的技术方案为: [0006] 市售工业级聚苯乙烯磺酸钙阳离子交换树脂经过上述三份专利申请提出脱除游离苯乙烯、残留的1,2-二氯乙烷和漂白等工艺中的一种或几种工艺处理后,再经含钙离子的组合物转化和纯化,制成聚苯乙烯磺酸钙树脂,其技术指标达到日本药典(JP14 e)规定的外观、钙含量、钾交换量和杂质(铵、重金属、砷、苯乙烯和钠)的标准,残留的1,...

AI Technical Summary

Problems solved by technology

The sodium resin exchanges potassium with the human body, the resin absorbs potassium and releases sodium, too much sodium will also have adverse effects in the body