Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of flax root extract in preparing medicine for preventing and treating hepatitis

A technology of root extract, flax, applied in the field of application in the preparation of drugs for the prevention and/or treatment of hepatitis

Inactive Publication Date: 2007-12-19
龙井民康生物制品厂 +1
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although the literature records that flax root can also be used medicinally, the actual situation of comprehensive utilization of flax is still to treat flax root as waste
Relevant scientific research, especially the specific medicinal value of flax root, has not seen any formal research reports so far

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The preparation of embodiment 1 flax root extract

[0036] 200 kg of flax (Linum usitatissimum L.) roots were extracted three times with 85% ethanol under reflux, the extracts were combined, and the ethanol was recovered under reduced pressure to obtain a crude extract.

[0037] The crude extract was dissolved in water, then extracted three times with ethyl acetate of the same volume as water, and the ethyl acetate portion was discarded.

[0038] The aqueous layer was extracted three times with the same volume of n-butanol; the n-butanol layers were combined.

[0039] The n-butanol extract was first extracted three times with the same volume of 5% aqueous sodium bicarbonate solution, and then extracted with water until neutral.

[0040] Recover the solvent under reduced pressure to obtain the n-butanol extract, which is the flax root extract.

Embodiment 2

[0041] Embodiment 2, flax root extract acute toxicity study

[0042] (1) Test animals

[0043] ICR mice, male, weighing 18-22 grams, provided by Weitong Lihua Experimental Animal Technology Co., Ltd., certificate number: SCDK (Beijing) 2002-0003

[0044] (2) Test drugs

[0045] Flax root extract, yellow-white powder, stored in the dark at 2-5°C, provided by Professor Qin Hailin of our institute, suspended in 0.5% CMC-Na when used.

[0046] (3) Test method

[0047] Ten mice were orally administered flax root extract at a concentration of 250 mg / ml, and each mouse was administered with a volume of 0.8 ml (ie the highest concentration and maximum volume). Within 7 days after administration, the signs and death of the mice were observed.

[0048] (4) Test results

[0049] After oral administration of flax root extract in mice, the signs did not change significantly. No deaths occurred.

[0050] (5 Conclusion

[0051] Oral administration of flax root extract 10g / kg to mice ...

experiment example 3

[0053] Experimental example 3, the effect of flax root extract on ConA-induced acute liver injury in mice

[0054] (1) Test animals

[0055] ICR mice, male, weighing 18-22 grams, provided by Weitong Lihua Experimental Animal Technology Co., Ltd., certificate number: SCDK (Beijing) 2002-0003

[0056] (2) Test drugs

[0057] Flax root extract, yellow-white powder, stored in the dark at 2-5°C, provided by Professor Qin Hailin of our institute, suspended in 0.5% CMC-Na when used.

[0058] (3) Positive control drug

[0059] Bicyclol, white powder, provided by Peking Union Medical College Pharmaceutical Factory, batch number 20030801, suspended with 0.5% CMC-Na when used.

[0060] 4.ConA

[0061] ConA was purchased from Sigma Corporation.

[0062] (4) Test method

[0063] The animals were randomly divided into 6 groups, 7 animals in each group, which were normal control group, ConA model group, flax root extract high-dose administration group, flax root extract medium-dose adm...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention discloses one kind of flax root extract, and its preparation process, medicine composition and application in preparing medicine for preventing and treating hepatitis.

Description

technical field [0001] The present invention relates to an extract of flax root, a preparation method of the extract, a pharmaceutical composition containing the extract and an application of the extract in preparing medicines for preventing and / or treating hepatitis. Background technique [0002] Flax (Linum usitatissimum L.) is a plant of the genus Linaceae, which is widely distributed all over the country. The plant is an annual herb with smooth stems and a plant height of 0.75-1.20m. There are branches at the top, which are umbrella-shaped; the cross-section of the stem is round and gray-green; the flax leaves are gray-green, alternate, with linear lanceolate edges, dense leaves, flat surface, 2-3.5cm long, 22cm wide ~4cm, the base of the leaf gradually narrows, blue-green; flowers are scattered on the top of the pedicel, the pedicel is erect, 2-7mm long, in racemes or open cymes; sepals are 5, narrow and long or long ovate, 5-7mm long , entire, without nectary glands,...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/55A61P1/16A61K125/00
Inventor 秦海林母海成李志宏张霞
Owner 龙井民康生物制品厂
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com