Application of histone deacetylase inhibitor in preparing antishock medicine

Abstract

The invention relates to applications of a histone deacetylase inhibitor in preparing an antishock drug, especially applications of S-(E)-3-[1-(1-benzo[d]oxazole-2-yl)-2-methylpropyl]-1H-1,2,3-triazole-4-yl]-N-Methylol acrylamide as shown in the specification in preparing the antishock drug, the shock is preferably selected from traumatic shock, hypovolemic shock, infectious shock, neurogenic shock, cardiogenic shock and anaphylactic shock, especially burning shock preferably.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular, the invention relates to the use of histone deacetylase inhibitors in the preparation of anti-shock medicines. Background technique [0002] Shock refers to a state in which the perfusion of surrounding tissues is insufficient due to insufficient cardiac output or abnormal distribution of peripheral blood flow, which cannot sustain life. Usually, there are hypotension and oliguria. Shock can be caused by hypovolemia, vasodilation, cardiogenic, or a combination of these factors. The common classifications of shock are: [0003] (1) Hypovolemic shock: refers to the loss of active components in blood, including hemorrhagic shock, plasma depletion shock and fluid depletion shock. [0004] (2) Traumatic shock: In addition to the reduction of effective circulation caused by blood loss and fluid loss, the toxin effect of tissue post-traumatic decomposition products and strong pain sti...

AI Technical Summary

Problems solved by technology

[0017] At present, there is no research on the use of compound NK-HDAC-1 in the preparation of anti-shock, especially burn and scald shock drugs

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