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Composition of diammonium glycyrrhizinate

A technology of diammonium glycyrrhizinate and a composition is applied in the directions of drug combinations, medical preparations containing active ingredients, medical formulas, etc., and can solve the problems of increasing the risk of drug side effects and the like

Active Publication Date: 2007-12-05
LIANYUNGANG RUNZHONG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This also increases the risk of drug side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Example 1 α-Diammonium Glycyrrhizinate and β-Diammonium Glycyrrhizinate Composition Sustained Release Tablets

[0054] prescription

[0055] α-Diammonium Glycyrrhizinate 160g

[0056] β-Diammonium Glycyrrhizinate 65g

[0057] Hypromellose 500g

[0058] Microcrystalline Cellulose 10g

[0059] 20% Acrylic Resin No. 2 40g

[0060] Magnesium Stearate 16g

[0061] Coating solution

[0062] Opadry (Y-1-7000) 24g

[0063] 85% ethanol 370g

[0064] A total of 1000 pieces were made

[0065] Plain tablet preparation method: pass α-diammonium glycyrrhizinate, β-diammonium glycyrrhizinate, hypromellose, and microcrystalline cellulose through a 80-mesh sieve, mix well, add 20% acrylic resin No. 2 soft material, pass through Sieve through a 20-mesh sieve, add magnesium stearate, mix evenly, and press into tablets.

[0066] Coated tablets: Take 370g of 85% ethanol, stir magnetically to make the liquid surface vortex, slowly add Opadry to the vortex until dissolved, continue ...

Embodiment 2

[0067] Example 2 α-Diammonium Glycyrrhizinate and β-Diammonium Glycyrrhizinate Composition Granules

[0068] prescription

[0069] α-Diammonium Glycyrrhizinate 75g

[0070] β-Diammonium Glycyrrhizinate 15g

[0071] Sodium Carboxymethyl Cellulose 80g

[0072] Aspartame 3g

[0073] Sucrose powder 200g

[0074] Mannitol 211.5g

[0075] Coconut essence 0.5g

[0076] A total of 1000 packs were made

[0077] Preparation method: crush α-diammonium glycyrrhizinate and β-diammonium glycyrrhizinate through a 100-mesh sieve; crush sodium carboxymethylcellulose, aspartame, sucrose powder, and mannitol through a 80-mesh sieve; take 50% of the Dissolve sucrose powder with appropriate amount of water to make syrup; take the remaining sucrose powder, sodium carboxymethyl cellulose, aspartame, mannitol, α-diammonium glycyrrhizinate, β-diammonium glycyrrhizinate and mix in a mixer , sprayed into soft materials made of syrup, granulated with a 15-mesh sieve, dried, sieved with a 40-mesh ...

Embodiment 3

[0078] Example 3 α-Diammonium Glycyrrhizinate and β-Diammonium Glycyrrhizinate Composition Dropping Pills

[0079] prescription

[0080] α-Diammonium Glycyrrhizinate 15g

[0081] β-Diammonium Glycyrrhizinate 5g

[0082] Macrogol 6000 35g

[0083] Distilled water 2.5g

[0084] Made 1000 pills in total

[0085] Preparation method: α-diammonium glycyrrhizinate, β-diammonium glycyrrhizinate and polyethylene glycol 6000 were crushed through a 60-mesh sieve, mixed evenly, heated in a water bath until polyethylene glycol 6000 was completely melted, added distilled water, stirred evenly, To obtain the feed liquid, the feed liquid is transferred to the dripping pill liquid storage tank, sealed and kept at 90°C. Adjust the valve, from top to bottom, so that the feed liquid is dropped into the simethicone oil cooling liquid at 10-15 °C, drop into pellets, remove oil, and dry. Instantly.

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PUM

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Abstract

The present invention provides one kind of medicine composition and its medicine preparation. The medicine composition consists of two isomers of diammonium glycyrrhizinate. The present invention provides also the medicine composition and its medicine preparation in treating hepatitis B and its related diseases, especially tumor.

Description

Background technique [0001] Diammonium Glycyrrhizinate is refined from glycyrrhizic acid extracted from the root of the natural plant medicine Glycyrrhiza Uralensis through two-step ammoniation. Pharmacological experiments have proved that diammonium glycyrrhizinate can significantly reduce the increase of serum alanine aminotransferase and aspartate aminotransferase caused by carbon tetrachloride, D-galactosamine and thioacetamide, and can also significantly reduce the effect of D-aminosemi-semi Morphological damage of lactose and improvement of chronic damage of liver morphology by immune factors. Diammonium glycyrrhizinate has strong anti-inflammatory, liver cell protection and liver function improvement effects. [0002] Glycyrrhizic acid in natural licorice has two different phase isomers, α and β, of which β is the main one. [0003] Due to the difference in configuration, the lipophilicity of β-diammonium glycyrrhizinate is weaker than that of the α body, so the abili...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P1/16A61P31/20
Inventor 沈军耿文军夏春光徐宏江
Owner LIANYUNGANG RUNZHONG PHARMA CO LTD
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